Association between ACE I/D genetic polymorphism and the severity of coronary artery disease in Vietnamese patients with acute myocardial infarction

BackgroundThe severity of coronary artery disease is a prognostic factor for major adverse cardiovascular events in patients diagnosed with acute myocardial infarction. ACE I/D polymorphism is one of the genetic factors that may affect the severity of coronary artery disease. This study aimed to investigate the association between ACE I/D genotypes and the severity of coronary artery disease in patients with acute myocardial infarction.Materials and methodsA single-center, prospective, observational study was conducted at the Department of Cardiology and Department of Interventional Cardiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam from January 2020 to June 2021. All participants diagnosed with acute myocardial infarction underwent contrast-enhanced coronary angiography. The severity of coronary artery disease was determined by Gensini score. ACE I/D genotypes were identified in all subjects by using the polymerase chain reaction method.ResultsA total of 522 patients diagnosed with first acute myocardial infarction were recruited. The patients' median Gensini score was 34.3. The II, ID, and DD genotype rates of ACE I/D polymorphism were 48.9%, 36.4%, and 14.7%, respectively. After adjusting for confounding factors, multivariable linear regression analysis showed that the ACE DD genotype was independently associated with a higher Gensini score compared with the II or ID genotypes.ConclusionThe DD genotype of the ACE I/D polymorphism was associated with the severity of coronary artery disease in Vietnamese patients diagnosed with first acute myocardial infarction

SOME METEO - HYDRO - DYNAMICAL FEATURES IN MEKONG RIVER MOUTH AREA

This paper provides some meteo-hydro-dynamical features in Mekong River Mouth area which were based on statistical results from longtime measurement data such as wind, wave, sea water level, and river discharge. Study results show that distribution features of wind and wave characteristics are corresponding to seasonal variation. Predominant wind and wave directions during NE Monsoon period is NE, and in W, SW directions during SW Monsoon period. NE Monsoon period is from November to April (strongest in December and January), SW Monsoon period is from June to September (strongest in August). During NE Monsoon period the wind velocity and wave height were higher than that of SW Monsoon period. Variation of SWL at Vungtau Station shows that the tide is semi-diurnal with maximum value occurred during NE monsoon period (highest in November), and minimum value occurred during SW Monsoon period (lowest in June). Variation of river discharge is similarly at two stations (Mythuan and Cantho). During flood season (from July to December) average monthly discharge was ranged from 4,000 to 15,800 m3/s. During dry season (from January to May) average monthly discharge at both stations was less than 4,000 m3/s. Statistical data show that Mekong River Mouth area is a region of strong and complicated hydro-dynamical interaction processes between river and sea. Key words: Monsoon, North-East (NE), South-West (SW), Sea Water Level (SWL), River discharge, Mekong River

ĐẶC ĐIỂM DÒNG CHẢY VEN BỜ BẮC TRUNG BỘ (HÀ TĨNH - THỪA THIÊN-HUẾ) THỜI KỲ 4/2016

This paper presents the modeled results of general current pattern (daily average value) in Northern Central Vietnam Coast (Ha Tinh - Thua Thien-Hue) during April 2016. Study results show that in general, current flowed from the North to the South with small and instable velocity (V ≈ 0.1 - 0.2 m/s). From 2nd to 6th April current flowed from the South to the North. From 7th to 29th April current flowed from the North to the South. During 13rd to 16th April current velocity was weak (V ≤ 0.1 m/s). In the southern region of Thua Thien-Hue province, the direction of current was instable (from 6th to 9th and from 20th to 22nd April current flowed from the South to the North). Current distribution pattern from modeled results was in accordance with the propagation characteristics of surface water temperatures in the studied area through data analysis of satellite images.Bài báo trình bày kết quả tính toán trường dòng chảy tổng hợp trung bình ngày cho khu vực ven bờ Bắc Trung Bộ (Hà Tĩnh - Thừa Thiên-Huế) thời kỳ 4/2016. Kết quả nghiên cứu cho thấy trong thời gian nghiên cứu nhìn chung dòng chảy tổng hợp trung bình ngày có hướng từ bắc xuống nam, tốc độ tương đối nhỏ V ≈ 0,1 - 0,2 m/s và không ổn định. Từ 2-6/4/2016 dòng chảy tổng hợp trung bình ngày ven bờ có hướng từ nam lên bắc. Từ 7-29/4/2016 dòng chảy ven bờ có hướng từ bắc xuống nam. Các ngày 13-16/4/2016 dòng chảy tổng hợp trung bình ngày có tốc độ nhỏ (V ≤ 0,1 m/s). Khu vực phía nam Thừa Thiên-Huế dòng chảy tổng hợp trung bình ngày có hướng bị biến động mạnh nhất (các ngày 6-9/4 và 20-22/4 hướng dòng từ nam lên bắc). Đặc điểm phân bố dòng chảy tính toán tương đối phù hợp với đặc điểm lan truyền nhiệt độ nước tầng mặt tại khu vực nghiên cứu qua số liệu phân tích ảnh vệ tinh

A Systematic Screen for Micro-RNAs Regulating the Canonical Wnt Pathway

MicroRNAs (miRs) and the canonical Wnt pathway are known to be dysregulated in human cancers and play key roles during cancer initiation and progression. To identify miRs that can modulate the activity of the Wnt pathway we performed a cell-based overexpression screen of 470 miRs in human HEK293 cells. We identified 38 candidate miRs that either activate or repress the canonical Wnt pathway. A literature survey of all verified candidate miRs revealed that the Wnt-repressing miRs tend to be anti-oncomiRs and down-regulated in cancers while Wnt-activating miRs tend to be oncomiRs and upregulated during tumorigenesis. Epistasis-based functional validation of three candidate miRs, miR-1, miR-25 and miR-613, confirmed their inhibitory role in repressing the Wnt pathway and suggest that while miR-25 may function at the level of â-catenin (β-cat), miR-1 and miR-613 act upstream of β-cat. Both miR-25 and miR-1 inhibit cell proliferation and viability during selection of human colon cancer cell lines that exhibit dysregulated Wnt signaling. Finally, transduction of miR-1 expressing lentiviruses into primary mammary organoids derived from Conductin-lacZ mice significantly reduced the expression of the Wnt-sensitive β-gal reporter. In summary, these findings suggest the potential use of Wnt-modulating miRs as diagnostic and therapeutic tools in Wnt-dependent diseases, such as cancer

Climate change threatens the conservation of one of the world’s most endangered transboundary tree species: Magnolia grandis

The Sino-Vietnamese border region is known for having unique and high levels of biodiversity. Global climate change is expected to alter the region’s climate and related changes in habitats and ecosystems will result in shifts in species’ distributions and increase the likelihood of local and global extinctions. Ecological Niche Models (ENMs) are widely used to predict the magnitude of potential species distribution shifts in response to climate change and inform conservation planning. Here, we present climate-based ENM projections of future climatically suitable habitat for the Daguo Mulian tree (Magnolia grandis), a critically endangered species of high ecological and cultural value in the Sino-Vietnamese border region. Projections of modeled climatically suitable habitat for M. grandis, both for the 2050s and 2070s, suggest significant habitat loss within conservation areas, and a defining shift in the location of suitable habitat. Future projections are conservative and do not account for dispersal limitations or species interactions or other factors, and thus may overestimate potential shifts and underestimate losses. Our results suggest that current conservation management efforts for M. grandis, which include community forest conservation monitoring combined with nursery cultivation efforts, can continue to have success if implemented in an adaptive management framework with long-term research and monitoring to inform forward-thinking decisions with future climatic suitability in mind. The results also underline how endangered species’ distributions may shift across borders as they track suitable climates, emphasizing that nations will need to cooperate to effectively manage threatened species and habitats and prevent extinctions

Climate change threatens the conservation of one of the world’s most endangered transboundary tree species: Magnolia grandis

The Sino-Vietnamese border region is known for having unique and high levels of biodiversity. Global climate change is expected to alter the region’s climate and related changes in habitats and ecosystems will result in shifts in species’ distributions and increase the likelihood of local and global extinctions. Ecological Niche Models (ENMs) are widely used to predict the magnitude of potential species distribution shifts in response to climate change and inform conservation planning. Here, we present climate-based ENM projections of future climatically suitable habitat for the Daguo Mulian tree (Magnolia grandis), a critically endangered species of high ecological and cultural value in the Sino-Vietnamese border region. Projections of modeled climatically suitable habitat for M. grandis, both for the 2050s and 2070s, suggest significant habitat loss within conservation areas, and a defining shift in the location of suitable habitat. Future projections are conservative and do not account for dispersal limitations or species interactions or other factors, and thus may overestimate potential shifts and underestimate losses. Our results suggest that current conservation management efforts for M. grandis, which include community forest conservation monitoring combined with nursery cultivation efforts, can continue to have success if implemented in an adaptive management framework with long-term research and monitoring to inform forward-thinking decisions with future climatic suitability in mind. The results also underline how endangered species’ distributions may shift across borders as they track suitable climates, emphasizing that nations will need to cooperate to effectively manage threatened species and habitats and prevent extinctions

Compressive Strength Development of High-Volume Fly Ash Ultra-High-Performance Concrete under Heat Curing Condition with Time

This research investigated the effect of fly ash content on the compressive strength development of ultra-high-performance concrete (UHPC) at different curing conditions, i.e., the standard curing condition and the heat curing. A total of 20 mixtures were prepared to cast specimens to measure the compressive strength at different ages from 3 days to 180 days. Additionally, 300 specimens were prepared to estimate the appropriate heat curing period at the early ages in terms of enhancing the 28-day compressive strength of UHPC with high content of fly ash (FA). From the regression analysis using test data, empirical equations were formulated to assess the compressive strength development of UHPC considering the FA content and maturity function. Test results revealed that the preference of the addition of FA for enhancing the compressive strength of UHPC requires the early heat curing procedure which can be recommended as at least 2 days under 90 °C. Moreover, the compressive strength of UHPC with FA under heat curing mostly reached its 28-day strength within 3 days. The proposed models based on the fib 2010 model can be a useful tool to reliably assess the compressive strength development of UHPC with high-volume fly ash (HVFA) (up to 70% fly ash content) under a heat curing condition that possesses a different performance from that of normal- and high-strength concrete. When 50% of the cement content was replaced by FA, the embodied CO2 emission for UHPC mixture reduced up to approximately 50%, which is comparable to the CO2 emission calculated from the conventional normal-strength concrete