448 research outputs found
RRE: a tool for the extraction of non-coding regions surrounding annotated genes from genomic datasets
Abstract
Summary: RRE allows the extraction of non-coding regions surrounding a coding sequence [i.e. gene upstream region, 5âČ-untranslated region (5âČ-UTR), introns, 3âČ-UTR, downstream region] from annotated genomic datasets available at NCBI.
Availability: RRE parser and web-based interface are accessible at http://www.bioinformatica.unito.it/bioinformatics/rre/rre.htm
The impact of financialisation on public health in times of COVID-19 and beyond
The substantial literature in political economy and soci- ology has shown that the increasing importance of finan- cial activities (financialisation) exhibits significant effects on many socioeconomic conditions. While these condi- tions are relevant to public health, the dominant focus of the literature has been centred on the impact of financial markets on health services and health-care systems. This paper analyses how the financialisation of non-financial corporations, real estate and pensions can worsen public health through the transformation of workplace and living conditions as well as financially dependent social groups' perception of health risk. Our analysis raises several ques- tions which aim to provide the basis of a future research agenda on the effects of financialisation on public and global health
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues.
We describe a new class of NO-donor hypoglycemic products obtained by joining tolbutamide, a typical hypoglycemic sulfonylurea, with a NO-donor moiety through a hard link. As NO-donors we chose either furoxan (1,2,5-oxadiazole 2-oxide) derivatives or the classical nitrooxy function. A preliminary biological characterization of these compounds, including stimulation of insulin release from cultured rat pancreatic ÎČ-cells and in vitro vasodilator and anti-aggregatory activities, is reported
The New âHidden Abodeâ: Reflections on Value and Labour in the New Economy
In a pivotal section of Capital, volume 1, Marx (1976: 279) notes that, in order to understand the capitalist production of value, we must descend into the âhidden abode of productionâ: the site of the labour process conducted within an employment relationship. In this paper we argue that by remaining wedded to an analysis of labour that is confined to the employment relationship, Labour Process Theory (LPT) has missed a fundamental shift in the location of value production in contemporary capitalism. We examine this shift through the work of Autonomist Marxists like Hardt and Negri, Lazaratto and Arvidsson, who offer theoretical leverage to prize open a new âhidden abodeâ outside employment, for example in the âproduction of organizationâ and in consumption. Although they can open up this new âhidden abodeâ, without LPT's fine-grained analysis of control/resistance, indeterminacy and structured antagonism, these theorists risk succumbing to empirically naive claims about the ânew economyâ. Through developing an expanded conception of a ânew hidden abodeâ of production, the paper demarcates an analytical space in which both LPT and Autonomist Marxism can expand and develop their understanding of labour and value production in today's economy. </jats:p
A generator of peroxynitrite activatable with red light
The generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) as âunconventionalâ therapeutics with precise spatiotemporal control by using light stimuli may open entirely new horizons for innovative therapeutic modalities. Among ROS and RNS, peroxynitrite (ONOO(â)) plays a dominant role in chemistry and biology in view of its potent oxidizing power and cytotoxic action. We have designed and synthesized a molecular hybrid based on benzophenothiazine as a red light-harvesting antenna joined to an N-nitroso appendage through a flexible spacer. Single photon red light excitation of this molecular construct triggers the release of nitric oxide (ËNO) and simultaneously produces superoxide anions (O(2)Ë(â)). The diffusion-controlled reaction between these two radical species generates ONOO(â), as confirmed by the use of fluorescein-boronate as a highly selective chemical probe. Besides, the red fluorescence of the hybrid allows its tracking in different types of cancer cells where it is well-tolerated in the dark but induces remarkable cell mortality under irradiation with red light in a very low concentration range, with very low light doses (ca. 1 J cm(â2)). This ONOO(â) generator activatable by highly biocompatible and tissue penetrating single photon red light can open up intriguing prospects in biomedical research, where precise and spatiotemporally controlled concentrations of ONOO(â) are required
Introduction to Eurocrisis, Neoliberalism and the Common
This introduction frames the articles collected in the special section as the outcome of a process of âself-educationâ taking place in the Italian free university network UniNomade 2.0 between 2010 and 2013. The open seminars and conferences orga- nized by UniNomade 2.0 took as their object of inquiry the concept of the Common, while the articles selected focus in particular on the sovereign debt crisis of the European Union (Eurocrisis) following the global financial crisis of 2008. The intro- duction thus summarizes the overall approach of contemporary âpost-operaistâ authors such as Toni Negri, Christian Marazzi, Maurizio Lazzarato, Andrea Fumagalli and Stefano Lucarelli, and Carlo Vercellone to the new role of financial capital, the transformation of money, the material constitution of Europe, the role played by the relationship between debtors and creditors, and the possibilities opened by the concept of Commonfare for struggles against austerity
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