Acute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europe

Background: The aim of the study was to document cardiovascular clinical findings, cardiac imaging, and laboratory markers in children presenting with the novel multisystem inflammatory syndrome associated with coronavirus disease 2019 (COVID-19) infection. Methods: This real-time internet-based survey has been endorsed by the Association for European Paediatric and Congenital Cardiologists Working Groups for Cardiac Imaging and Cardiovascular Intensive Care. Children 0 to 18 years of age admitted to a hospital between February 1 and June 6, 2020, with a diagnosis of an inflammatory syndrome and acute cardiovascular complications were included. Results: A total of 286 children from 55 centers in 17 European countries were included. The median age was 8.4 years (interquartile range, 3.8-12.4 years) and 67% were boys. The most common cardiovascular complications were shock, cardiac arrhythmias, pericardial effusion, and coronary artery dilatation. Reduced left ventricular ejection fraction was present in over half of the patients, and a vast majority of children had raised cardiac troponin when checked. The biochemical markers of inflammation were raised in most patients on admission: elevated C-reactive protein, serum ferritin, procalcitonin, N-terminal pro B-type natriuretic peptide, interleukin-6 level, and D-dimers. There was a statistically significant correlation between degree of elevation in cardiac and biochemical parameters and the need for intensive care support (P<0.05). Polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 was positive in 33.6%, whereas immunoglobulin M and immunoglobulin G antibodies were positive in 15.7% cases and immunoglobulin G in 43.6% cases, respectively, when checked. One child in the study cohort died. Conclusions: Cardiac involvement is common in children with multisystem inflammatory syndrome associated with the Covid-19 pandemic. The majority of children have significantly raised levels of N-terminal pro B-type natriuretic peptide, ferritin, D-dimers, and cardiac troponin in addition to high C-reactive protein and procalcitonin levels. In comparison with adults with COVID-19, mortality in children with multisystem inflammatory syndrome associated with COVID-19 is uncommon despite multisystem involvement, very elevated inflammatory markers, and the need for intensive care support.info:eu-repo/semantics/publishedVersio

Classification of Electromyographic Signals during Finger Isometric Flexion: Using Electrodes Arrays

The classification of electromiographic signals provides a method to identify one’s intent or movement. This paper presents a study on choosing the best model for a classifier used to group electromiographic signals into classes corresponding to the isometric flexion effort of different fingers. The signals were collected from the Flexor Digitorum Superficialis and Profundus of seven healthy subjects. Different features (root mean square - RMS, average rectified value - ARV, mean and median frequency) and different classifier structures (discriminant analysis, nearest neighbor analysis, naive Bayes algorithm, neural network, fuzzy logic based algorithm) were implemented with classification success rates ranging from 50 to 99 %. The success rate of the classifiers corresponds to the ability of a numerical system to decode the physiological manifestations associated with the finger movements

Open web-based learning environments and knowledge forums to support people with special needs

Internet technology and, in particular Web‐based services, have the potential to revolutionise approaches to learning. These new forms of learning could provide additional educational opportunities for people with special needs to support their social integration and integration into the knowledge‐based economy. This paper starts with a short presentation on open Web‐based learning environments and knowledge forums followed by a discussion of some recent results on e‐learning and special needs users. Two examples of learning portals for supporting e‐learning forums developed within the European projects, EURO H 2000 and a DAAD German‐Romanian cooperation, are given. Ways of including users with special needs in projects on the design of learning materials and environments are also discussed

Recent outcome of liver transplantation for Budd Chiari syndrome - analysis of the european liver transplant registry (ELTR) and affiliated centres

..