3 research outputs found
Recurrent intra-articular osteoid osteoma of the hip after radiofrequency ablation: a case report and review of the literature
We present a case of a 53-year-old woman with recurrent intra-articular osteoid osteoma of the hip 6 months after initial treatment with percutaneous radiofrequency ablation. En bloc surgical excision of the osteoid osteoma and prophylactic internal fixation for impending stress fracture was performed. The patient is pain free, has returned to normal function and there is no sign of recurrence at the one-year follow-up. Intraarticular osteoid osteoma, present a diagnostic challenge and often they are misdiagnosed. Minimally invasive ablation techniques can fail in significant percentage and then surgical excision with histological confirmation remains the definitive treatment of choice
Experimental Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus Treated with a Polylactide Carrier Releasing Linezolid
Background: The effectiveness of a new delivery system consisting of
polymerized dilactide (PLA) with incorporated linezolid was investigated
in a rabbit model as a means of treating methicillin-resistant
Staphylococcus aureus (MRSA) osteomyelitis.
Methods: The PLA-linezolid system was prepared after thorough stirring
of PLA with linezolid at a 10: 1 ratio. Experimental osteomyelitis was
established in 40 rabbits by a modification of the Norden model with
MRSA as the test isolate. After a hole had been drilled in the upper
right femur, the isolate was inoculated using a thin needle working as a
foreign body. At three weeks, the needle was removed and cultured, and
the PLA-linezolid system was implanted in half the animals (group B);
the remaining half was the control group (group A). Animals were
sacrificed at regular intervals; tissue around the site of implantation
was examined for pathologic changes and cultured quantitatively.
Results: The prepared system eluted linezolid in vitro at concentrations
much greater than the minimum inhibitory concentration (MIC) of the test
pathogen for 11 days. At three weeks after inoculation of the test
isolate, all animals had osteomyelitis. By the sixth week, bacterial
growth from cancellous bone of group B was significantly lower than that
in group A. However, this effect was not maintained until the end of the
study (weeks 8 and 10), when the differences in bacterial growth in the
two groups were not significant.
Conclusion: Polymerized dilactide mixed with 10% linezolid achieved
partial arrest of the offending pathogen in an experimental model of
osteomyelitis caused by MRSA