Multiplexed genotyping of ABC transporter polymorphisms with the Bioplex suspension array

We have developed and validated a consolidated bead-based genotyping platform, the Bioplex suspension array for simultaneous detection of multiple single nucleotide polymorphisms (SNPs) of the ATP-binding cassette transporters. Genetic polymorphisms have been known to influence therapeutic response and risk of disease pathologies. Genetic screening for therapeutic and diagnostic applications thus holds great promise in clinical management. The allele-specific primer extension (ASPE) reaction was used to assay 22 multiplexed SNPs for eight subjects. Comparison of the microsphere-based ASPE assay results to sequencing results showed complete concordance in genotype assignments. The Bioplex suspension array thus proves to be a reliable, cost-effective and high-throughput technological platform for genotyping. It can be easily adapted to customized SNP panels for specific applications involving large-scale mutation screening of clinically relevant markers

Scanning methodology

Illustrate the various sampling strategy used in different phase of a product cycle, comparing two types of inspection tools and presenting three case studies to illustrate the importance of early detection. The impact of defects towards wafer yield will also be addressed.Master of Science (Microelectronics

SINGAPORE'S FUTURE ENERGY OPTIONS - KEY CHALLENGES

Bachelor'sBACHELOR OF SCIENCE (REAL ESTATE

Investigation of nano-porous silicon fabricated by electrochemical etching

72 p.Porous silicon is quickly becoming an increasingly important and versatile electronic material in today's fabrication technology. Nowadays, because of its high reactivity due to its large surface area of the pores, porous silicon has been demonstrated as a useful sacrificial layer in surface micro machining. It's unique morphology made it an attractive material for the fabrication of the chemical sensing microstructures. It is also being use as planar emitters for efficient emission of electrons. In addition, porous silicon serves as a good substrate material for both the carbon nanotube material for the enhancement of the field emission property.Master of Science (Microelectronics

Examination of inter-country income inequality using Penn World Table Data.

The central objective of this research project is to empirically examine inter-country inequality for the period 1960 to 1995. That is, we look at whether income inequalityamong countries has been rising or falling. Our project is therefore essentially an empirical test of the convergence hypothesis. Our data set comes largely from the Penn World Table version 5.6. Our sample covers 162 countries and the period 1960 to 1995

Room temperature sequential ionic deposition (SID) of Ag2S nanoparticles on TiO2 hierarchical spheres for enhanced catalytic efficiency

10.1039/c4ta06674jJournal of Materials Chemistry A3126509-651

The effect of crystallinity on photocatalytic performance of Co3O4 water-splitting cocatalysts

Cocatalysts, when loaded onto a water splitting photocatalyst, accelerate the gas evolution reaction and improve the efficiency of the photocatalyst. In this paper, we report that the efficiency of the photocatalyst is enhanced using an amorphous cobalt oxide cocatalyst. The WO3 film, when loaded with amorphous or nanocrystalline Co3O4, shows an improvement of up to 40% in photocurrent generation and 34% in hydrogen gas evolution. The effect of cocatalyst crystallinity on performance was systematically studied, and we found that the photocurrent deteriorates with the conversion of the cocatalyst to a highly crystalline phase at an annealing temperature of 500 degrees C. The mechanism of this effect was studied in detail using electrochemical impedance spectroscopy, and the enhancement effect produced by the amorphous cocatalyst is attributed to the large density of unsaturated catalytically active sites in the amorphous material

A highly active hydrogen evolution electrocatalyst based on a cobalt–nickel sulfide composite electrode

A novel Co9S8–NixSy/Ni foam composite material was synthesized through the thermal decomposition of a cobalt–thiourea molecular precursor onto a 3D metallic support. The obtained electrode exhibited good activity toward the hydrogen evolution reaction in an alkaline medium, requiring a small overpotential of 163 mV at a current density of 10 mA cm?2, which is one of the lowest ever reported among transition metal sulfide materials