<span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight: bold" lang="EN-US">Evaluation<span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight:bold" lang="EN-US"> <span style="mso-bidi-font-size:15.0pt; font-weight:normal;mso-bidi-font-weight:bold" lang="EN-US">of<span style="mso-bidi-font-size:15.0pt;font-weight: normal;mso-bidi-font-weight:bold" lang="EN-US"> <span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight: bold" lang="EN-US">Antimicrobial and Modulatory activity<span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight:bold" lang="EN-US"> of the extract of <i style="mso-bidi-font-style:normal">Richardia brasiliensis</i> Gomes </span></span></span></span></span></span>

619-622The emergence of resistant microorganisms and also the toxicity associated with antimicrobial drugs increase the need of research for new active principles. Richardia brasiliensis, a weed used popularly as an expectorant, antiemetic, and diaphoretic. The extracts have coumarins, flavonoids, steroids, triterpenoids, alkaloids and resin, as secondary metabolites. The present study aimed to test the potential antimicrobial and modulator of the ethanolic and hexanic extracts of R. brasiliensis. The ethanolic and hexanic extracts were tested for their antimicrobial effect and in combination with aminoglycosides and antifungal against standard and multi-resistant microorganisms by the broth microdilution method with culture medium Brain Heart Infusion (BHI). It was observed that the association between antibiotics and ethanolic and hexanic extracts showed clinically relevant results on the tests with multi-resistant bacteria. The natural products from R. brasiliensis demonstrated a modulating action against the microorganisms used. These results can represent a new effort to combat antibiotic resistant bacteria. </span