2 research outputs found
<span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight: bold" lang="EN-US">Evaluation<span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight:bold" lang="EN-US"> <span style="mso-bidi-font-size:15.0pt; font-weight:normal;mso-bidi-font-weight:bold" lang="EN-US">of<span style="mso-bidi-font-size:15.0pt;font-weight: normal;mso-bidi-font-weight:bold" lang="EN-US"> <span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight: bold" lang="EN-US">Antimicrobial and Modulatory activity<span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight:bold" lang="EN-US"> of the extract of <i style="mso-bidi-font-style:normal">Richardia brasiliensis</i> Gomes </span></span></span></span></span></span>
619-622The emergence of resistant
microorganisms and also the toxicity associated with antimicrobial drugs
increase the need of research for new active principles. Richardia brasiliensis, a weed
used popularly as an expectorant, antiemetic, and diaphoretic. The extracts have coumarins,
flavonoids, steroids, triterpenoids, alkaloids and resin, as secondary
metabolites. The present study aimed to test the potential antimicrobial and
modulator of the ethanolic and hexanic extracts of
R. brasiliensis. The ethanolic and hexanic extracts were
tested for their antimicrobial effect and in combination with aminoglycosides
and antifungal against standard and multi-resistant microorganisms by the broth
microdilution method with culture medium Brain Heart Infusion (BHI). It was
observed that the association between antibiotics and ethanolic and hexanic
extracts showed clinically relevant results on the tests with multi-resistant
bacteria. The natural products from
R. brasiliensis
demonstrated a modulating action against the microorganisms used. These results
can represent a new effort to combat antibiotic resistant bacteria.
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