Parkin Deficiency Delays Motor Decline and Disease Manifestation in a Mouse Model of Synucleinopathy

In synucleinopathies, including Parkinson's disease, partially ubiquitylated α-synuclein species phosphorylated on serine 129 (PS129-α-synuclein) accumulate abnormally. Parkin, an ubiquitin-protein ligase that is dysfunctional in autosomal recessive parkinsonism, protects against α-synuclein-mediated toxicity in various models

Economic Analysis of Knowledge: The History of Thought and the Central Themes

Following the development of knowledge economies, there has been a rapid expansion of economic analysis of knowledge, both in the context of technological knowledge in particular and the decision theory in general. This paper surveys this literature by identifying the main themes and contributions and outlines the future prospects of the discipline. The wide scope of knowledge related questions in terms of applicability and alternative approaches has led to the fragmentation of research. Nevertheless, one can identify a continuing tradition which analyses various aspects of the generation, dissemination and use of knowledge in the economy

Persévérance scolaire des élèves inuit: Influence de la perception, de l'attitude et de l'approche pédagogique des enseignants inuit et qallunaat (non inuit)

Rapport de recherche 2012-RP-145358Recherche publiée grâce au soutien du Fonds de recherche du Québec- Sociéte et culture (FRQSC) et du ministère de l’Éducation, du Loisir et du Sport (MELS) et avec la collaboration de la Commission scolaire Kativik (CSK)