856 research outputs found
Religion is Secularised Tradition: Jewish and Muslim Circumcisions in Germany
This article demonstrates that the legal reasoning dominant in modern states secularises traditions by converting them into âreligionsâ. Using a case study on Germanyâs recent regulation of male circumcision, we illustrate that religions have (at least) three dimensions: religiosity (private belief, individual right and autonomous choice); religious law (a divinely ordained legal code); and religious groups (public threat). When states restrict traditions within these three dimensions, they construct âreligionsâ within a secularisation triangle. Our theoretical model of a secularisation triangle illuminates that, in many Western states, there is a three-way relationship between a post-Christian state and both its Jewish and Muslim minorities. Our two theoretical proposalsâthe secularisation triangle and the trilateral relationshipâcontribute to a re-examination of religious freedom from the perspective of minority traditions and minority communities
Auctions with Heterogeneous Items and Budget Limits
We study individual rational, Pareto optimal, and incentive compatible
mechanisms for auctions with heterogeneous items and budget limits. For
multi-dimensional valuations we show that there can be no deterministic
mechanism with these properties for divisible items. We use this to show that
there can also be no randomized mechanism that achieves this for either
divisible or indivisible items. For single-dimensional valuations we show that
there can be no deterministic mechanism with these properties for indivisible
items, but that there is a randomized mechanism that achieves this for either
divisible or indivisible items. The impossibility results hold for public
budgets, while the mechanism allows private budgets, which is in both cases the
harder variant to show. While all positive results are polynomial-time
algorithms, all negative results hold independent of complexity considerations
Coronary artery endothelial dysfunction is positively correlated with low density lipoprotein and inversely correlated with high density lipoprotein subclass particles measured by nuclear magnetic resonance spectroscopy.
OBJECTIVE: The association between cholesterol and endothelial dysfunction remains controversial. We tested the hypothesis that lipoprotein subclasses are associated with coronary endothelial dysfunction.
METHODS AND RESULTS: Coronary endothelial function was assessed in 490 patients between November 1993 and February 2007. Fasting lipids and nuclear magnetic resonance (NMR) lipoprotein particle subclasses were measured. There were 325 females and 165 males with a mean age of 49.8+/-11.6 years. Coronary endothelial dysfunction (epicardial constriction>20% or increase in coronary blood flow<50% in response to intracoronary acetylcholine) was diagnosed in 273 patients, the majority of whom (64.5%) had microvascular dysfunction. Total cholesterol and LDL-C (low density lipoprotein cholesterol) were not associated with endothelial dysfunction. One-way analysis and multivariate methods adjusting for age, gender, diabetes, hypertension and lipid-lowering agent use were used to determine the correlation between lipoprotein subclasses and coronary endothelial dysfunction. Epicardial endothelial dysfunction was significantly correlated with total (p=0.03) and small LDLp (LDL particles) (p<0.01) and inversely correlated with total and large HDLp (high density lipoprotein particles) (p<0.01).
CONCLUSIONS: Epicardial, but not microvascular, coronary endothelial dysfunction was associated directly with LDL particles and inversely with HDL particles, suggesting location-dependent impact of lipoprotein particles on the coronary circulation
Hunter-gatherer childrenâs object play and tool use: An ethnohistorical analysis
Learning to use, make, and modify tools is key to our speciesâ success. Researchers have hypothesized that play with objects may have a foundational role in the ontogeny of tool use and, over evolutionary timescales, in cumulative technological innovation. Yet, there are few systematic studies investigating childrenâs interactions with objects outside the post-industrialized West. Here, we survey the ethnohistorical record to uncover cross-cultural trends regarding hunter-gatherer childrenâs use of objects during play and instrumental activities. Our dataset, consisting of 434 observations of childrenâs toys and tools from 54 hunter-gatherer societies, reveals several salient trends: Most objects in our dataset are used in play. Children readily manufacture their own toys, such as dolls and shelters. Most of the objects that children interact with are constructed from multiple materials. Most of the objects in our dataset are full-sized or miniature versions of adult tools, reflecting learning for adult roles. Children also engage with objects related to child culture, primarily during play. Taken together, our findings show that hunter-gatherer children grow up playing, making, and learning with objects
Childhood Trauma and Effective Empirically Based Interventions
Trauma affects many children in various ways globally. According to SAMHSA (2017), the âoccurrence of child trauma is very prevalent, and 75% of children reported experiencing at least one traumatic event by age 16â. Traumatic events consist of âpsychological, physical, or sexual abuse; community or school violence; witnessing or experiencing domestic violence; national disasters or terrorism; commercial sexual exploitation; sudden or violent loss of a loved one; refugee or war experiences; military family-related stressors; physical or sexual assault; neglect; and serious accidents or life-threatening illnessâ (SAMHSA, 2017). This literature review evaluates three different attachment-based, trauma-informed interventions for young children 0-7 years of age which are: Attachment and Bio-Behavioral Catchup (ABC), Child-Parent Psychotherapy (CPP), and Parent-Child Interaction Therapy (PCIT). Throughout this review, childhood trauma will be defined, and the current occurrence rates will be discussed. Furthermore, the descriptions of the above therapies, clinical trials, and research findings will be examined, and a discussion of the literature review findings will follow
Efficiency Guarantees in Auctions with Budgets
In settings where players have a limited access to liquidity, represented in
the form of budget constraints, efficiency maximization has proven to be a
challenging goal. In particular, the social welfare cannot be approximated by a
better factor then the number of players. Therefore, the literature has mainly
resorted to Pareto-efficiency as a way to achieve efficiency in such settings.
While successful in some important scenarios, in many settings it is known that
either exactly one incentive-compatible auction that always outputs a
Pareto-efficient solution, or that no truthful mechanism can always guarantee a
Pareto-efficient outcome. Traditionally, impossibility results can be avoided
by considering approximations. However, Pareto-efficiency is a binary property
(is either satisfied or not), which does not allow for approximations.
In this paper we propose a new notion of efficiency, called \emph{liquid
welfare}. This is the maximum amount of revenue an omniscient seller would be
able to extract from a certain instance. We explain the intuition behind this
objective function and show that it can be 2-approximated by two different
auctions. Moreover, we show that no truthful algorithm can guarantee an
approximation factor better than 4/3 with respect to the liquid welfare, and
provide a truthful auction that attains this bound in a special case.
Importantly, the liquid welfare benchmark also overcomes impossibilities for
some settings. While it is impossible to design Pareto-efficient auctions for
multi-unit auctions where players have decreasing marginal values, we give a
deterministic -approximation for the liquid welfare in this setting
Bribeproof mechanisms for two-values domains
Schummer (Journal of Economic Theory 2000) introduced the concept of
bribeproof mechanism which, in a context where monetary transfer between agents
is possible, requires that manipulations through bribes are ruled out.
Unfortunately, in many domains, the only bribeproof mechanisms are the trivial
ones which return a fixed outcome.
This work presents one of the few constructions of non-trivial bribeproof
mechanisms for these quasi-linear environments. Though the suggested
construction applies to rather restricted domains, the results obtained are
tight: For several natural problems, the method yields the only possible
bribeproof mechanism and no such mechanism is possible on more general domains.Comment: Extended abstract accepted to SAGT 2016. This ArXiv version corrects
typos in the proofs of Theorem 7 and Claims 28-29 of prior ArXiv versio
In vitro effects of resistin on epithelial to mesenchymal transition (EMT) in MCF-7 and MDA-MB-231 breast cancer cells - qRT-PCR and Westen blot analyses data.
Resistin is an adipokine produced by the white adipocytes and adipose-derived macrophages, which mediates inflammation and insulin resistance Huang et al., 1997 and Renehan et al., 2008 Feb. Here, we provide data on the effect of resistin on epithelial to mesenchymal transition (EMT) in breast cancer cells in vitro. As model systems, we used human MCF-7 (low-metastatic) and MDA-MB-231 (high-metastatic) breast cancer cell lines. To optimize experimental conditions, we treated the cells with various concentrations of resistin (12.5, 25 and 50 ng/ml) for different time intervals (6 and 24 hours), and measured SOCS3 mRNA expression by using qRT-PCR analysis. Further, we used qRT-PCR and Western blot analyses to measure the expression of various epithelial (E-cadherin, claudin-1) and mesenchymal (SNAIL, SLUG, ZEB1, TWIST1, fibronectin, and vimentin) markers after resistin treatment. This data article is part of a study Avtanski et al., 2019 May, where detailed interpretation and discussion can be found
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