3 research outputs found
Assessing Earthquake Early Warning Using Sparse Networks in Developing Countries: Case Study of the Kyrgyz Republic
The first real-time digital strong-motion network in Central Asia has been installed in the Kyrgyz Republic since 2014. Although this network consists of only 19 strong-motion stations, they are located in near-optimal locations for earthquake early warning and rapid response purposes. In fact, it is expected that this network, which utilizes the GFZ-Sentry software, allowing decentralized event assessment calculations, not only will provide useful strong motion data useful for improving future seismic hazard and risk assessment, but will serve as the backbone for regional and on-site earthquake early warning operations. Based on the location of these stations, and travel-time estimates for P- and S-waves, we have determined potential lead times for several major urban areas in Kyrgyzstan (i.e., Bishkek, Osh, and Karakol) and Kazakhstan (Almaty), where we find the implementation of an efficient earthquake early warning system would provide lead times outside the blind zone ranging from several seconds up to several tens of seconds. This was confirmed by the simulation of the possible shaking (and intensity) that would arise considering a series of scenarios based on historical and expected events, and how they affect the major urban centers. Such lead times would allow the instigation of automatic mitigation procedures, while the system as a whole would support prompt and efficient actions to be undertaken over large areas
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Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality.
Mitochondria contain many copies of a circular DNA molecule (mtDNA), which has been observed as a mixture of normal and mutated states known as heteroplasmy. Elevated heteroplasmy at a single mtDNA site, m.3243A > G, leads to neurologic, sensory, movement, metabolic, and cardiopulmonary impairments. We measured leukocyte mtDNA m.3243A > G heteroplasmy in 789 elderly men and women from the bi-racial, population-based Health, Aging, and Body Composition Study to identify associations with age-related functioning and mortality. Mutation burden for the m.3243A > G ranged from 0-19% and elevated heteroplasmy was associated with reduced strength, cognitive, metabolic, and cardiovascular functioning. Risk of all-cause, dementia and stroke mortality was significantly elevated for participants in the highest tertiles of m.3243A > G heteroplasmy. These results indicate that the accumulation of a rare genetic disease mutation, m.3243A > G, manifests as several aging outcomes and that some diseases of aging may be attributed to the accumulation of mtDNA damage
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Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality.
Mitochondria contain many copies of a circular DNA molecule (mtDNA), which has been observed as a mixture of normal and mutated states known as heteroplasmy. Elevated heteroplasmy at a single mtDNA site, m.3243A > G, leads to neurologic, sensory, movement, metabolic, and cardiopulmonary impairments. We measured leukocyte mtDNA m.3243A > G heteroplasmy in 789 elderly men and women from the bi-racial, population-based Health, Aging, and Body Composition Study to identify associations with age-related functioning and mortality. Mutation burden for the m.3243A > G ranged from 0-19% and elevated heteroplasmy was associated with reduced strength, cognitive, metabolic, and cardiovascular functioning. Risk of all-cause, dementia and stroke mortality was significantly elevated for participants in the highest tertiles of m.3243A > G heteroplasmy. These results indicate that the accumulation of a rare genetic disease mutation, m.3243A > G, manifests as several aging outcomes and that some diseases of aging may be attributed to the accumulation of mtDNA damage