Flow-chart of the data collection process.

<p>¹ ECR: Eindhoven Cancer Registry ² CBG: Central Bureau of Genealogy.</p

Socio-demographic and clinical correlates of moderate-vigorous physical activity (min/day).

<p>Gender (0 = male; 1 = female), partner (1 = yes; 0 = no), education (1 = yes; 0 = no), employed (1 = yes; 0 = no), current smoker (1 = yes; 0 = no); tumour site (0 = colon; 1 = rectal), tumour stage (1–2 = 0; 3–4 = 1); chemotherapy (1 = yes; 0 = no), radiotherapy (1 = yes; 0 = no), co-morbidity (1 = moderate/severe; 0 = none/mild).</p><p>Significant associations in the multivariate analysis are presented in bold.</p

Tailoring exercise interventions to comorbidities and treatment-induced adverse effects in patients with early stage breast cancer undergoing chemotherapy: a framework to support clinical decisions

<p><b>Purpose:</b> Delivery of exercise interventions to patients with early-stage breast cancer undergoing chemotherapy requires complex clinical decisions. The purpose of this study was to develop a framework to support clinical decisions for tailoring exercise interventions to common comorbidities and cancer treatment-induced adverse effects.</p> <p><b>Method:</b> Tailored exercise prescriptions were developed in four steps, following the i3-S strategy. All steps were based on current best available evidence, complemented with expert opinions. First, common comorbidities and treatment-induced adverse effects were identified. In the subsequent steps, contra-indications and restrictions for exercise were described, along with possible exercise adaptations. In the final step, the obtained information was synthesized into a framework.</p> <p><b>Results:</b> Prevalent comorbidities were hypertension, heart disease, diabetes mellitus, (osteo)arthritis, chronic obstructive pulmonary disease, and obesity. Adverse effects included conditions induced by pretreatment (e.g., lymphedema as a result of surgery) or by chemotherapy (e.g., reduced blood cell counts). Adaptations to the recommended exercise program were related to exercise tolerance, safety, and hygiene. A framework was proposed to guide clinical decisions during the exercise intervention.</p> <p><b>Conclusion:</b> Comorbidities and adverse effects of breast cancer treatment require exercise adaptations. The proposed framework provides guidance on tailored exercise prescriptions in patients with breast cancer undergoing chemotherapy.Implications for Rehabilitation</p><p>Exercise is recommended for patients with breast cancer undergoing chemotherapy, but requires complex clinical decisions of the health professional.</p><p>We identified the most important comorbidities and adverse effects of breast cancer treatment, and the resultant contra-indications and restrictions to exercise.</p><p>We incorporated these findings into a clinical decision framework that provides suggestions for exercise adaptations in patients with breast cancer undergoing chemotherapy.</p><p></p> <p>Exercise is recommended for patients with breast cancer undergoing chemotherapy, but requires complex clinical decisions of the health professional.</p> <p>We identified the most important comorbidities and adverse effects of breast cancer treatment, and the resultant contra-indications and restrictions to exercise.</p> <p>We incorporated these findings into a clinical decision framework that provides suggestions for exercise adaptations in patients with breast cancer undergoing chemotherapy.</p

Effects of the intervention on primary and secondary outcome measures in patients treated with auto-SCT.

<p>Effects of the intervention on primary and secondary outcome measures in patients treated with auto-SCT.</p

Effects of ≥10 physiotherapy sessions on primary and secondary outcome measures in patients treated with auto-SCT.

<p>Effects of ≥10 physiotherapy sessions on primary and secondary outcome measures in patients treated with auto-SCT.</p

Consort diagram.

<p>Consort diagram.</p