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Suiting the Modern Woman
Suiting the Modern Woman documented the evolution of women's power dressing in the 20th century by featuring four major components: thirteen period suit silhouettes, the power suits of twenty-eight influential and successful high profile Texas women, a look at the career and creations of Dallas designer, Richard Brooks, who created the professional wardrobe for former Texas Governor Ann Richards, and a media room which showcased images of working women in television and movie clips, advertisements, cartoons, and fashion guidebooks. The exhibition served as an application for contemporary museum education theory. Acting as both the exhibition coordinator and educator provided an opportunity to develop interpretative strategies and create a meaningful visitor experience
Identification, life history, and ecology of peritrich ciliates as epibionts on calanoid copepods in the Chesapeake Bay
Epibiotic relationships are a widespread phenomenon in marine, estuarine and freshwater environments, and include diverse epibiont organisms such as bacteria, protists, rotifers, and barnacles. Despite its wide occurrence, epibiosis is still poorly known regarding its consequences, advantages, and disadvantages for host and epibiont. Most studies performed about epibiotic communities have focused on the epibionts' effects on host fitness, with few studies emphasizing on the epibiont itself.
The present work investigates species composition, spatial and temporal fluctuations, and aspects of the life cycle and attachment preferences of Peritrich epibionts on calanoid copepods in Chesapeake Bay, USA. Two species of Peritrich ciliates (Zoothamnium intermedium Precht, 1935, and Epistylis sp.) were identified to live as epibionts on the two most abundant copepod species (Acartia tonsa and Eurytemora affinis) during spring and summer months in Chesapeake Bay. Infestation prevalence was not significantly correlated with environmental variables or phytoplankton abundance, but displayed a trend following host abundance.
Investigation of the life cycle of Z. intermedium suggested that it is an obligate epibiont, being unable to attach to non-living substrates in the laboratory or in the field. Formation of free-swimming stages (telotrochs) occurs as a result of binary fission, as observed for other peritrichs, and is also triggered by death or molt of the crustacean host. Attachment success of dispersal stages decreased as telotroch age increased, suggesting that colonization rates in nature may be strongly dependent on intense production of telotrochs by the epibiont ciliates.
Laboratory experiments demonstrated that Z. intermedium colonizes equally adult and copepodite stages of A. tonsa and E. affinis. The epibiont is also able to colonize barnacle nauplii and a harpacticoid copepod, when these were the only living host available, but fails to colonize non-crustacean hosts, such as the rotifer Brachionus calyciflorus or polychaete larvae. When the epibiont could choose between adults of A. tonsa and alternate hosts from the zooplankton community, it always colonized preferentially its primary host, with only a few telotrochs attaching to other crustaceans (barnacle nauplii and harpacticoid copepod), and to rotifer eggs, suggesting that specific cues may be involved in host selection by this epibiotic species
Genarchella parva Travassos, Artigas & Pereira, 1928 (Digenea: Derogenidae) em peixes em dois ambientes no sul do Brasil: morfologia e comentários sobre a lista de hospedeiros
Genarchella parva Travassos, Artigas & Pereira, 1928 has been reported mainly in Characidae hosts. The morphology of this species has been known based on specimens collected mainly by Travassos and researchers (20s and 60s decades) and also from specimens in Argentina. The goal of this study was to describe the morphology of G. parva, provide the parameters of the infections from different fish species and discuss the host’s checklist from Brazil. Specimens of G. parva were collected from species of Astyanax Baird & Girard, 1854 and Psalidodon Eigenmann, 1911 in Jacuí Delta (north of the Lake Guaíba, in the municipality of Porto Alegre) and Lagoon Itapeva (municipality of Terra de Areia), extreme south of Brazil. The localization of the genital pore of G. parva and Genarchella fragilis Lunaschi, 1990 was compared and discussed. The prevalence of G. parva was higher in Psalidodon aff. fasciatus (Cuvier, 1819) (12.9%) from Itapeva Lagoon and Astyanax henseli Melo & Buckup, 2006 (11.43%) from Jacuí Delta than other species examined. A host’s checklist of G. parva in Brazil is provided and two previous reports are discussed. This study is the first report of G. parva in A. henseli and A. lacustris from southern Brazil, while Itapeva Lagoon is considered a new locality record for G. parva.Genarchella parva Travassos, Artigas & Pereira, 1928 ha sido mayormente registrada en hospedadores pertenecientes a la familia Characidae. La morfología de esta especie se conoce a partir de especímenes recolectados principalmente por Travassos y otros investigadores (en las décadas de 1920 y 1960), así como de especímenes procedentes de Argentina. El propósito de este estudio es describir la morfología de G. parva, proporcionar los parámetros de infecciones en diferentes especies de peces y discutir la lista de hospedadores en Brasil. Se recolectaron especímenes de G. parva de las especies de Astyanax Baird & Girard, 1854, y Psalidodon Eigenmann, 1911, en el Delta do Jacuí (límite norte del Lago Guaíba, en el municipio de Porto Alegre) y en la Lagoa Itapeva (municipio de Terra de Areia), ubicados en el sur de Brasil. Además, se comparó y discutió la ubicación del poro genital de G. parva en relación con Genarchella fragilis Lunaschi, 1990. La prevalencia de G. parva fue notablemente alta en Psalidodon aff. fasciatus (Cuvier, 1819) (12,9%) de Lagoa Itapeva y Astyanax henseli Melo & Buckup, 2006 (11,43%) del Delta del Jacuí en comparación con otras especies examinadas. Se presenta una lista detallada de hospedadores de G. parva en Brasil, y se analizan dos registros en particular. Este estudio constituye el primer registro de G. parva en A. henseli y A. lacustris para el sur de Brasil, mientras que la Lagoa Itapeva se considera un nuevo registro de localidad para G. parva.Genarchella parva Travassos, Artigas & Pereira, 1928 foi registrada principalmente em hospedeiros da família Characidae. A morfologia desta espécie é conhecida a partir de espécimes coletados principalmente por Travassos e outros pesquisadores (nas décadas de 20 e 60) e também por espécimes da Argentina. O objetivo do presente estudo foi descrever a morfologia de G. parva, fornecer os parâmetros das infecções em diferentes espécies de peixes e discutir a lista de hospedeiros do Brasil. Espécimes de G. parva foram coletados em espécies de Astyanax Baird & Girard, 1854 e Psalidodon Eigenmann, 1911 do Delta do Jacuí (limite norte do Lago Guaíba, no município de Porto Alegre) e Lagoa Itapeva (município de Terra de Areia), no extremo sul do Brasil. A localização do poro genital de G. parva e Genarchella fragilis Lunaschi, 1990 foi comparada e discutida. A prevalência de G. parva foi elevada em Psalidodon aff. fasciatus (Cuvier, 1819) (12,9%) da Lagoa Itapeva e Astyanax henseli Melo & Buckup, 2006 (11,43%) do Delta do Jacuí em relação as outras espécies examinadas. Uma lista de hospedeiros de G. parva no Brasil é fornecida e dois registros foram discutidos. Este estudo é o primeiro registro de G. parva em A. henseli e A. lacustris para o sul do Brasil, enquanto que a Lagoa Itapeva é considerada como novo registro de localidade para G. parva
Relação hospedeiro‑parasita durante infestação por Epistylis sp. (Ciliophora: Epistylididae) em peixes ciclídeos e pimelodídeos cultivados
The objective of this work was to describe the host‑Epistylis sp. relationship during infestation on farmed fish. Five Nile tilapia (Oreochromis niloticus) and ten hybrid surubim catfish (Pseudoplatystoma reticulatum x P. corruscans), all diseased, were used for in vivo morphological analysis of sessile peritrichs by contrast microscopy. Fragments of infected tissues were subjected to histological processing and scanning electron microscopy. Epistylis sp. caused hemorrhagic ulcer disease, and cichlids were more prone to develop infestations throughout the body surface due to the attachment of the colonies to the scales, which did not occur with pimelodids. Multifocal granulomatous dermatitis was observed, associated with the hydropic degeneration of the epithelium and to ulcerative areas of necrosis. Microscopic examination showed the presence of bacterial microflora associated to Epistylis sp. peduncles. Therefore, this species can be considered a portal of entry for opportunistic bacteria.O objetivo deste trabalho foi descrever a relação hospedeiro‑Epistylis sp. durante infestação em peixes cultivados. Foram utilizados cinco tilápias‑do‑nilo (Oreochromis niloticus) e dez híbridos de surubim (Pseudoplatystoma reticulatum x P. corruscans), todos parasitados, para análise morfológica in vivo de peritríquios sésseis por microscopia de contraste de fase. Fragmentos de tecidos infectados foram processados para histologia e microscopia eletrônica de varredura. Epistylis sp. causou doença ulcerativa hemorrágica, e os ciclídeos foram mais susceptíveis ao parasitismo na superfície do corpo em razão da fixação das colônias nas escamas, o que não ocorreu nos pimelodídeos. Foi observada ocorrência de dermatite granulomatosa multifocal, associada à degeneração hidrópica do epitélio e às áreas ulcerativas de necrose. O estudo microscópico mostrou a presença de bactérias associadas aos pedúnculos de Epistylis sp. Portanto, esta espécie pode ser considerada porta de entrada para bactérias oportunistas
On the Benefit of Dual-domain Denoising in a Self-supervised Low-dose CT Setting
Computed tomography (CT) is routinely used for three-dimensional non-invasive
imaging. Numerous data-driven image denoising algorithms were proposed to
restore image quality in low-dose acquisitions. However, considerably less
research investigates methods already intervening in the raw detector data due
to limited access to suitable projection data or correct reconstruction
algorithms. In this work, we present an end-to-end trainable CT reconstruction
pipeline that contains denoising operators in both the projection and the image
domain and that are optimized simultaneously without requiring ground-truth
high-dose CT data. Our experiments demonstrate that including an additional
projection denoising operator improved the overall denoising performance by
82.4-94.1%/12.5-41.7% (PSNR/SSIM) on abdomen CT and 1.5-2.9%/0.4-0.5%
(PSNR/SSIM) on XRM data relative to the low-dose baseline. We make our entire
helical CT reconstruction framework publicly available that contains a raw
projection rebinning step to render helical projection data suitable for
differentiable fan-beam reconstruction operators and end-to-end learning.Comment: This work has been submitted to the IEEE for possible publication.
Copyright may be transferred without notice, after which this version may no
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Noise2Contrast: Multi-Contrast Fusion Enables Self-Supervised Tomographic Image Denoising
Self-supervised image denoising techniques emerged as convenient methods that
allow training denoising models without requiring ground-truth noise-free data.
Existing methods usually optimize loss metrics that are calculated from
multiple noisy realizations of similar images, e.g., from neighboring
tomographic slices. However, those approaches fail to utilize the multiple
contrasts that are routinely acquired in medical imaging modalities like MRI or
dual-energy CT. In this work, we propose the new self-supervised training
scheme Noise2Contrast that combines information from multiple measured image
contrasts to train a denoising model. We stack denoising with domain-transfer
operators to utilize the independent noise realizations of different image
contrasts to derive a self-supervised loss. The trained denoising operator
achieves convincing quantitative and qualitative results, outperforming
state-of-the-art self-supervised methods by 4.7-11.0%/4.8-7.3% (PSNR/SSIM) on
brain MRI data and by 43.6-50.5%/57.1-77.1% (PSNR/SSIM) on dual-energy CT X-ray
microscopy data with respect to the noisy baseline. Our experiments on
different real measured data sets indicate that Noise2Contrast training
generalizes to other multi-contrast imaging modalities
Randomized controlled phase 2 trial of hydroxychloroquine in childhood interstitial lung disease
Background
No results of controlled trials are available for any of the few treatments offered to children with interstitial lung diseases (chILD). We evaluated hydroxychloroquine (HCQ) in a phase 2, prospective, multicentre, 1:1-randomized, double-blind, placebo-controlled, parallel-group/crossover trial. HCQ (START arm) or placebo were given for 4 weeks. Then all subjects received HCQ for another 4 weeks. In the STOP arm subjects already taking HCQ were randomized to 12 weeks of HCQ or placebo (= withdrawal of HCQ). Then all subjects stopped treatment and were observed for another 12 weeks.
Results
26 subjects were included in the START arm, 9 in the STOP arm, of these four subjects participated in both arms. The primary endpoint, presence or absence of a response to treatment, assessed as oxygenation (calculated from a change in transcutaneous O 2 -saturation of ≥ 5%, respiratory rate ≥ 20% or level of respiratory support), did not differ between placebo and HCQ groups. Secondary endpoints including change of O 2 -saturation ≥ 3%, health related quality of life, pulmonary function and 6-min-walk-test distance, were not different between groups. Finally combining all placebo and all HCQ treatment periods did not identify significant treatment effects. Overall effect sizes were small. HCQ was well tolerated, adverse events were not different between placebo and HCQ.
Conclusions
Acknowledging important shortcomings of the study, including a small study population, the treatment duration, lack of outcomes like lung function testing below age of 6 years, the small effect size of HCQ treatment observed requires careful reassessments of prescriptions in everyday practice (EudraCT-Nr.: 2013-003714-40, www.clinicaltrialsregister.eu , registered 02.07.2013)
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