The run-times of different methods (in seconds) with the genes left after pruning based on different CV cut-offs.

λ1 and λ2 were respectively kept at 0.01 and 0.02. The mark “X” means that we could not run those methods due to inordinate amount of time required.</p

The networks between the hub-genes whose degree changed from IL and PL to LHB.

The top row corresponds to the genes whose degree decreased from IL and PL to LHB, while the bottom row corresponds to the genes whose degree increased.</p