29 research outputs found
Author Correction: Early pregnancy ultrasound measurements and prediction of first trimester pregnancy loss: A logistic model (Scientific Reports, (2020), 10, 1, (1545), 10.1038/s41598-020-58114-3)
The original version of this Article contained an error in the spelling of the author Patricia J. Goedecke which was incorrectly given as Patricia J. Goeske. The original Article has been corrected
Coronavirus Disease 2019 (COVID-19) Vaccination and Assisted Reproduction Outcomes: A Systematic Review and Meta-analysis.
OBJECTIVE: To assess the association between coronavirus disease 2019 (COVID-19) vaccination and female assisted reproduction outcomes through a systematic review and meta-analysis.
DATA SOURCES: We searched Medline (OVID), EMBASE, Web of Science, Cochrane Library, and ClinicalTrials.gov on January 11, 2023, for original articles on assisted reproduction outcomes after COVID-19 vaccination. The primary outcome was rates of clinical pregnancy; secondary outcomes included number of oocytes retrieved, number of mature oocytes retrieved, fertilization rate, implantation rate, ongoing pregnancy rate, and live-birth rate.
METHODS OF STUDY SELECTION: Two reviewers independently screened citations for relevance, extracted pertinent data, and rated study quality. Only peer-reviewed published studies were included.
TABULATION, INTEGRATION, AND RESULTS: Our query retrieved 216 citations, of which 25 were studies with original, relevant data. Nineteen studies reported embryo transfer outcomes, with a total of 4,899 vaccinated and 13,491 unvaccinated patients. Eighteen studies reported data on ovarian stimulation outcomes, with a total of 1,878 vaccinated and 3,174 unvaccinated patients. There were no statistically significant results among our pooled data for any of the primary or secondary outcomes: clinical pregnancy rate (odds ratio [OR] 0.94, 95% CI 0.88-1.01, P=.10), number of oocytes retrieved (mean difference -0.26, 95% CI -0.68 to 0.15, P=.21), number of mature oocytes retrieved (mean difference 0.31, 95% CI -0.14 to 0.75, P=.18), fertilization rate (OR 0.99, 95% CI 0.87-1.11, P=.83), implantation rate (OR 0.92, 95% CI 0.84-1.00, P=.06), ongoing pregnancy rate (OR 0.95, 95% CI 0.86-1.06, P=.40), or live-birth rate (OR 0.95, 95% CI 0.78-1.17, P=.63). A subanalysis based on country of origin and vaccine type was also performed for the primary and secondary outcomes and did not change the study results.
CONCLUSION: Vaccination against COVID-19 is not associated with different fertility outcomes in patients undergoing assisted reproductive technologies.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO, CRD42023400023
The Exploration and Practice of Party Member of College Students rdquo;Recognizing Position and Taking Responsibility for a Model”
AbstractNowadays, it has become more important to strengthen the education, management and training work of the party members of college students. Our school has carried out the party members of college students. rdquo;recognizing position and taking responsibility for a model” activity for two years. And obtained some experience. The party members of college students rdquo;recognizing position and taking responsibility for a model” activity should set up scientific positions, define their responsibilities clearly and strengthen the management and assessment
Tris-Ethynylphenyl-amine Fluorophores: Synthesis, Characterisation and Test of Performances in Luminescent Solar Concentrators
Two fluorescent dyes (CT-tEPhA=3,3′,3′′-(nitrilotris(benzene-4,1-diyl))tris(1-(thiophen-2-yl)prop-2-yn-1-one and T-tEPhA=tris(4-(thiophen-2-ylethynyl)phenyl)amine) have been synthesised and characterised in different solvents and in a poly(methyl methacrylate) (PMMA) matrix. In both cases, relatively high Stokes shifts (SS) and quantum yields (QY) have been displayed. Notably, CT-tEPhA based on a mild electron-attracting carbonyl group coupled with the electron-donating amino-centre, shows superior light emitting properties (higher SS, red-shifted emission, QY > 40%) suggesting application in light harvesting systems. Photocurrent measurements of CT-tEPhA/PMMA films yield a maximum optical efficiency of 6.32% that is greater than that of fluorophores with same emission window and comparable to that of red-emitting ones. This efficiency might be improved by extending the push-pull character of CT-tEPhA to cover the maximum efficiency of the Si-based PV cell. Nevertheless, these results clearly support the use of push-pull fluorophores based on the tris(4-ethynylphenyl)amine core in solar collectors
A Comparison of Three Downregulation Approaches for Poor Responders Undergoing in Vitro Fertilization
Objective
To assess the efficacy of three different GnRH agonist (GnRH-a) stimulation regimens to improve ovarian response in poor responders undergoing IVF. Design
Retrospective cohort study. Setting
Center for Reproductive Health at the University of Cincinnati Medical Center. Patient(s)
Women diagnosed as poor responders who presented consecutively from January 1999 to January 2004. Intervention(s)
Patients underwent three different stimulation regimens during IVF cycles: [1] stop protocol: GnRH-a 500 μg/d administered from the midluteal phase to the start of menses, then gonadotropins from day 2 of cycle, [2] microdose flare: GnRH-a 20 μg administered twice daily with gonadotropins from day 2 to the day of hCG administration, or [3] regular dose flare: gonadotropins beginning with GnRH-a on day 2 at 1 mg/d for 3 days, followed by 250 μg/d until the day of hCG administration. Main Outcome Measure(s)
Ovarian response, implantation rates, clinical pregnancy and delivery rates. Result(s)
Sixty-one IVF cycles were included in the study. None of the comparisons reached statistical significance; however, the microdose group demonstrated a trend toward a higher completed pregnancy rate. Conclusion(s)
The microdose flare protocol for poor responders demonstrated a trend toward higher delivery rates. A larger prospective study would need to be performed to determine whether this trend leads to a significant finding in this patient population
A Comparison of Three Downregulation Approaches for Poor Responders Undergoing in Vitro Fertilization
Objective
To assess the efficacy of three different GnRH agonist (GnRH-a) stimulation regimens to improve ovarian response in poor responders undergoing IVF. Design
Retrospective cohort study. Setting
Center for Reproductive Health at the University of Cincinnati Medical Center. Patient(s)
Women diagnosed as poor responders who presented consecutively from January 1999 to January 2004. Intervention(s)
Patients underwent three different stimulation regimens during IVF cycles: [1] stop protocol: GnRH-a 500 μg/d administered from the midluteal phase to the start of menses, then gonadotropins from day 2 of cycle, [2] microdose flare: GnRH-a 20 μg administered twice daily with gonadotropins from day 2 to the day of hCG administration, or [3] regular dose flare: gonadotropins beginning with GnRH-a on day 2 at 1 mg/d for 3 days, followed by 250 μg/d until the day of hCG administration. Main Outcome Measure(s)
Ovarian response, implantation rates, clinical pregnancy and delivery rates. Result(s)
Sixty-one IVF cycles were included in the study. None of the comparisons reached statistical significance; however, the microdose group demonstrated a trend toward a higher completed pregnancy rate. Conclusion(s)
The microdose flare protocol for poor responders demonstrated a trend toward higher delivery rates. A larger prospective study would need to be performed to determine whether this trend leads to a significant finding in this patient population