Additional file 1: of Inflammatory profiles in canine intervertebral disc degeneration

A more detailed representation of included samples in addition to Table  1 in the original article. (DOCX 29 kb

Additional file 2: of Inflammatory profiles in canine intervertebral disc degeneration

Significant differences and confidence intervals of statistical analyses. (DOCX 25 kb

Additional file 4: of Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model

PGE 2 normalized for total protein. (TIFF 15443 kb

Additional file 1: of Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model

Synthesis and degradation of poly-N-isopropylacrylamide (pNIPAAM) MgFe-LDH hydrogels and controlled release of CXB in vitro. (DOCX 89 kb

Consensus for statements regarding a definition for spinal osteoarthritis for use in research and clinical practice: A Delphi study

Objective To determine consensus among an international, multidisciplinary group of experts regarding definitions of spinal osteoarthritis for research and for clinical practice. Methods A 15 member, multidisciplinary steering committee generated 117 statements for a three-round Delphi study. Experts in back pain and/or osteoarthritis were identified and invited to participate. In round one, participants could propose additional statements for voting. All statements were rated on a 1-9 Likert scale, and consensus was set at ≥70% of respondents agreeing or disagreeing with the statement and <15% of respondents providing the opposite response. Results In total, 255 experts from 11 different professional backgrounds were invited. From 173 available experts, 116 consented to participate. In round one, 103 participants completed the survey, followed by 85 of 111 participants in round two (77%) and 87 of 101 participants in round three (86%). One third of participants were from Europe (30%), most were male (58%), one fifth were physiotherapists (21%), and over one third had been in their profession for 11-20 years (35%). Of 131 statements, consensus was achieved for 71 statements (54%): 53 in agreement (75%) and 18 in disagreement (25%). Conclusion While there was consensus for statements for definitions of spinal osteoarthritis that were analogous to definitions of osteoarthritis in appendicular joints, a future definition still needs refinement. Importantly, this Delphi highlighted that a future definition should be considered across a spectrum of structural changes and patient symptoms, and expressed on a progressive scale