Development and evaluation of lessons in socialized learning for grade I: volumes I-II

Thesis (Ed.M.)--Boston Universit

Is the good life the easy life?

ABSTRACT. Three studies examined folk concepts of the good life. Participants rated the desirability and moral goodness of a life as a function of the happiness, meaning, and effort experienced. Happiness and meaning were solid predictors of the good life, replicating King and Napa (1998). Study 1 (N = 381) included wealth as an additional factor. Results showed little desire for exorbitant (over moderate) wealth, but also a desire to avoid poverty. When effort was operationalized as number of hours worked, respondents desired the easy life, particularly at moderate levels of income. When effort was operationalized as effortful engagement (Study 2), 186 undergraduates and 178 community adults rated the hardworking life as morally superior to the easy life. Community adults preferred meaningful lives of ease, while college students preferred meaningful lives that involved effort. Study 3 (N = 359) found the meaningful, effortful life was rated as most morally good, and the happy effortful life was rated as most desirable, happy, and meaningful. The role of hard work in naïve notions of The Good Life is discussed. A number of potential components of the good life require effort – namely, economic success (Weber, 1930/1976), a sense of purpos

Adverse Childhood Experiences and Current Cannabis Use among U.S. Young Adults

Cannabis use is a significant public health issue among U.S. young adults. The objective of this study was to assess the associations between adverse childhood experiences (ACEs) and current cannabis use among U.S. young adults. We conducted a secondary analysis of the 2021 Behavioral Risk Factor Surveillance System (BRFSS) data, which involved 498 U.S. young adults 18-24 years old who had data available for analysis on ACEs and current cannabis use. Unadjusted and adjusted logistic regression models were fitted to examine the associations between ACEs and current cannabis use. Adjusted models included participants’ sex, race/ethnicity, education level, and household income level. One-fourth (25.5%) of participants reported current cannabis use, and 21.3% reported one ACE, 25.2% reported 2-3 ACEs, and 38.4% reported ≥4 ACEs. Unadjusted (odds ratio [OR]=4.22, 95% confidence interval [CI]=1.91-9.33) and adjusted (adjusted OR=4.23, 95%CI=1.57-11.38) model results indicated that participants who experienced ≥1 ACE were at increased odds of reporting current cannabis use than participants with no ACEs. Unadjusted (OR=5.79, 95%CI=2.40-14.00) and adjusted (AOR=6.48, 95%CI=2.15-19.55) model results indicated that participants who experienced ≥4 ACEs were at increased odds of reporting current cannabis use than participants with no ACEs. Adjusted model results revealed that experiencing living with a household member who had a mental illness or sexual abuse increased the odds of reporting current cannabis use. Results demonstrated relations among ACEs and current cannabis use in young adulthood, especially among those who experienced ≥4 ACEs and experienced living with a household member who had a mental illness or sexual abuse

Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: the Sun Exposure and Vitamin D Supplementation (SEDS) Study

BACKGROUND Adults living in the sunny Australian climate are at high risk of skin cancer, but vitamin D deficiency (defined here as a serum 25-hydroxyvitamin D (25(OH)D) concentration of less than 50 nmol/L) is also common. Vitamin D deficiency may be a risk factor for a range of diseases. However, the optimal strategies to achieve and maintain vitamin D adequacy (sun exposure, vitamin D supplementation or both), and whether sun exposure itself has benefits over and above initiating synthesis of vitamin D, remain unclear. The Sun Exposure and Vitamin D Supplementation (SEDS) Study aims to compare the effectiveness of sun exposure and vitamin D supplementation for the management of vitamin D insufficiency, and to test whether these management strategies differentially affect markers of immune and cardio-metabolic function. METHODS/DESIGN The SEDS Study is a multi-centre, randomised controlled trial of two different daily doses of vitamin D supplementation, and placebo, in conjunction with guidance on two different patterns of sun exposure. Participants recruited from across Australia are aged 18-64 years and have a recent vitamin D test result showing a serum 25(OH)D level of 40-60 nmol/L. DISCUSSION This paper discusses the rationale behind the study design, and considers the challenges but necessity of data collection within a non-institutionalised adult population, in order to address the study aims. We also discuss the challenges of participant recruitment and retention, ongoing engagement of referring medical practitioners and address issues of compliance and participant retention. TRIAL REGISTRATION Australia New Zealand Clinical Trials Registry: ACTRN12613000290796 Registered 14 March 2013

Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders

Alpha-synuclein (aSyn) is a pre-synaptic monomeric protein that can form aggregates in neurons in Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB), and in oligodendrocytes in multiple system atrophy (MSA). Although aSyn in astrocytes has previously been described in PD, PDD and DLB, the biochemical properties and topographical distribution of astrocytic aSyn have not been studied in detail. Here, we present a systematic investigation of aSyn astrocytic pathology using an expanded antibody toolset covering the entire sequence and key post-translational modifications (PTMs) of aSyn in Lewy body disorders (LBDs) and in MSA. Astrocytic aSyn was detected in the limbic cortical regions of LBDs but were absent in main pathological regions of MSA. The astrocytic aSyn was revealed only with antibodies against the mid N-terminal and non-amyloid component (NAC) regions covering aSyn residues 34–99. The astroglial accumulations were negative to canonical aSyn aggregation markers, including p62, ubiquitin and aSyn pS129, but positive for phosphorylated and nitrated forms of aSyn at Tyrosine 39 (Y39), and not resistant to proteinase K. Our findings suggest that astrocytic aSyn accumulations represent a major part of aSyn pathology in LBDs and possess a distinct sequence and PTM signature that is characterized by both N- and C-terminal truncations and modifications at Y39. This is the first description that aSyn accumulations are made solely from N- and C-terminally cleaved aSyn species and the first report demonstrating that astrocytic aSyn is a mixture of Y39 phosphorylated and nitrated species. These observations underscore the importance of systematic characterization of aSyn accumulations in different cell types to capture the aSyn pathological diversity in the brain. Our findings combined with further studies on the role of astrocytic pathology in the progression of LBDs can pave the way towards identifying novel disease mechanisms and therapeutic targets

Student Attitudes Toward Research in an Undergraduate Social Science Research Methods Course

This study used a mixed-methods longitudinal design to investigate change in students’ understanding, attitudes, anxiety, perceptions of relevance, and disinterest in a required social science undergraduate research methods course across a semester. Participants were 78 undergraduates (94% women, 6% men; 92% white non-Hispanic/Latinx, M age = 25.62, SD = 7.17) at a university in the United States. Results suggest that participant attitudes toward and perceptions of research methods shifted over the course of the semester. Overall, anxiety decreased, while positive attitudes increased. However, initial perceptions and changes in perceptions varied among the three course sections. Over time, students largely recognized the course’s relevance and conveyed positive attitudes toward research and their success in overcoming the challenge of completing the course. Implications for pedagogy include the need for continued assessment of learners, development of students’ self-concept as researchers, teaching of research as a process, and connection to application

Valence band offset of the ZnO/AlN heterojunction determined by X-ray photoemission spectroscopy

The valence band offset of ZnO/AlN heterojunctions is determined by high resolution x-ray photoemission spectroscopy. The valence band of ZnO is found to be 0.43±0.17 eV below that of AlN. Together with the resulting conduction band offset of 3.29±0.20 eV, this indicates that a type-II (staggered) band line up exists at the ZnO/AlN heterojunction. Using the III-nitride band offsets and the transitivity rule, the valence band offsets for ZnO/GaN and ZnO/InN heterojunctions are derived as 1.37 and 1.95 eV, respectively, significantly higher than the previously determined values

Seismicity on the western Greenland Ice Sheet : surface fracture in the vicinity of active moulins

Author Posting. © American Geophysical Union, 2015. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Earth Surface 120 (2015): 1082–1106, doi:10.1002/2014JF003398.We analyzed geophone and GPS measurements collected within the ablation zone of the western Greenland Ice Sheet during a ~35 day period of the 2011 melt season to study changes in ice deformation before, during, and after a supraglacial lake drainage event. During rapid lake drainage, ice flow speeds increased to ~400% of winter values, and icequake activity peaked. At times >7 days after drainage, this seismicity developed variability over both diurnal and longer periods (~10 days), while coincident ice speeds fell to ~150% of winter values and showed nightly peaks in spatial variability. Approximately 95% of all detected seismicity in the lake basin and its immediate vicinity was triggered by fracture propagation within near-surface ice (<330 m deep) that generated Rayleigh waves. Icequakes occurring before and during drainage frequently were collocated with the down flow (west) end of the primary hydrofracture through which the lake drained but shifted farther west and outside the lake basin after the drainage. We interpret these results to reveal vertical hydrofracture opening and local uplift during the drainage, followed by enhanced seismicity and ice flow on the downstream side of the lake basin. This region collocates with interferometric synthetic aperture radar-measured speedup in previous years and could reflect the migration path of the meltwater supplied to the bed by the lake. The diurnal seismic signal can be associated with nightly reductions in surface melt input that increase effective basal pressure and traction, thereby promoting elevated strain in the surficial ice.Research by J. Carmichael was supported by a NASA NESSF Fellowship grant NNX08AU82H and NSF grant ANT-0424589. The fieldwork and additional analyses were supported by the National Science Foundation's Office of Polar Programs (NSF-OPP) through ARC-1023382, awarded to I. Joughin, and ARC-1023364, awarded to S. B. Das and M. D. Behn. Matt King is a recipient of an Australian Research Council Future Fellowship (project number FT110100207).2015-12-2

Evaluation of an Afterschool Children’s Healthy Eating and Exercise Program

Background: The purpose of this study was to examine the feasibility of the Children’s Healthy Eating and Exercise Program (CHEE) in an afterschool program of an elementary school. Methods:Students in a low-income elementary school were recruited to participate in the program. Thirty-three children were in the intervention group. Twenty-four children in the comparison group were recruited from after school clubs in the same elementary school.The CHEE Program consisted of 18 sessions, featuring nutrition (20 min) and physical activity (40 min) lessons. Nutrition lessons were adapted from the Traffic Light Diet. Other lessons included MyPlate, my refrigerator, my lunchbox, and a healthy foods tasting activity. Multiple physical activities were utilized in the program including soccer, dance, relay races, tag, and other fun games. Data were collected at the beginning and end of the program. Results: Children in both groups reported eating more vegetables at the post-intervention measurement. Children in the intervention group indicated that they learned about healthy eating and new physical activities due to their participation in the program. Conclusions: Future studies are needed to discover barriers to behavior change as well as apply a more rigorous design to examine the impact of the CHEE Program