Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype

Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the US and Canada might be disproportionately affected. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network

Precore and Basal Core Promoter Hepatitis B Virus (HBV) Variants Are Present From a Young Age and Differ Across HBV Genotypes

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/167511/1/hep31506_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/167511/2/hep31506.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/167511/3/hep31506-sup-0001-Supinfo.pd

Comparison of HBV RNA and Hepatitis B Core Related Antigen With Conventional HBV Markers Among Untreated Adults With Chronic Hepatitis B in North America

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/170799/1/hep32018_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/170799/2/hep32018-sup-0001-Supinfo.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/170799/3/hep32018.pd

Low Incidence of Adverse Outcomes in Adults With Chronic Hepatitis B Virus Infection in the Era of Antiviral Therapy

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/168359/1/hep31554_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/168359/2/hep31554.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/168359/3/hep31554-sup-0001-Supinfo.pd

Low Incidence of Adverse Outcomes in Adults With Chronic Hepatitis B Virus Infection in the Era of Antiviral Therapy

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/168359/1/hep31554_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/168359/2/hep31554.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/168359/3/hep31554-sup-0001-Supinfo.pd

Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver

Studies of human hepatitis B virus (HBV) immune pathogenesis are hampered by limited access to liver tissues and technologies for detailed analyses. Here, utilizing imaging mass cytometry (IMC) to simultaneously detect 30 immune, viral, and structural markers in liver biopsies from patients with hepatitis B e antigen+ (HBeAg+) chronic hepatitis B, we provide potentially novel comprehensive visualization, quantitation, and phenotypic characterizations of hepatic adaptive and innate immune subsets that correlated with hepatocellular injury, histological fibrosis, and age. We further show marked correlations between adaptive and innate immune cell frequencies and phenotype, highlighting complex immune interactions within the hepatic microenvironment with relevance to HBV pathogenesis

A global scientific strategy to cure hepatitis B

Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE-HBV) is a coalition of experts dedicated to accelerating the discovery of a cure for chronic hepatitis B. Following extensive consultation with more than 50 scientists from across the globe, as well as key stakeholders including people affected by HBV, we have identified gaps in our current knowledge and new strategies and tools that are required to achieve HBV cure. We believe that research must focus on the discovery of interventional strategies that will permanently reduce the number of productively infected cells or permanently silence the covalently closed circular DNA in those cells, and that will stimulate HBV-specific host immune responses which mimic spontaneous resolution of HBV infection. There is also a pressing need for the establishment of repositories of standardised HBV reagents and protocols that can be accessed by all HBV researchers throughout the world. The HBV cure research agenda outlined in this position paper will contribute markedly to the goal of eliminating HBV infection worldwide