The feasibility study for the creation of production based on technology of lost-foam casting

The problems of establishing a new foundry in Kazakhstan utilizing Lost-foam casting technology are discussed in this article. The study’s main objectives are to determine the technical and financial viability of arranging such production in the country. Calculations of the manufacturing program were carried out as part of the study, and a financial- economic model of the project was developed. The research shows that establishing such a foundry is feasible, and the project may be recommended for execution

Feasibility study of the creation of a special coke production in Kazakhstan

The article examines the issues of creating a special coke production in the country. The objectives of the study were to assess the technical and economic feasibility of organizing such production. In the course of the study, the production program, investment estimates and a model of financial and economic payback of the project were calculated. The study confirms the effectiveness of creating a special coke production in Kazakhstan, and the project itself can be recommended for implementation

Feasibility study of the creation of a special coke production in Kazakhstan

The article examines the issues of creating a special coke production in the country. The objectives of the study were to assess the technical and economic feasibility of organizing such production. In the course of the study, the production program, investment estimates and a model of financial and economic payback of the project were calculated. The study confirms the effectiveness of creating a special coke production in Kazakhstan, and the project itself can be recommended for implementation

Importance of trabecular anisotropy in finite element predictions of patellar strain after Total Knee Arthroplasty

Patellar fracture and anterior knee pain remain major complications after Total Knee Arthroplasty (TKA). Patient-specific finite element (FE) models should help improve understanding of these complications through estimation of joint and bone mechanics. However, sensitivity of predictions on modeling tech- niques and approaches is not fully investigated. In particular, the importance of patellar bone anisotropy, usually omitted in FE models, on strain prediction is still unknown. The objective of this study was thus to estimate the influence of modeling patellar trabecular anisotropy on prediction of patellar strain in TKA models. We compared FE-derived strain predictions with isotopic and anisotropic material properties using 17 validated FE models of the patella after TKA. We considered both non-resurfaced and resurfaced patellae, in a load-bearing TKA joint. We evaluated and compared the bone volume above a strain threshold and, in addition, estimated if the difference in isotopic and anisotropic predictions was consistent between patellae of different average bone volume fraction. Compared to the anisotropic reference, the isotropic prediction of strained volume was 3.7 ± 1.8 times higher for non-resurfaced patellae and 1.5 ± 0.4 times for resurfaced patellae. This difference was higher for patellae with lower average bone volume fraction. This study indicates that strain predictions acquired via isotropic patellar FE models should be inter- preted with caution, especially when patellae of different average bone volume fraction are compared

Students’ physical and mental disorders: How to avoid victim behavior through exercise and sport

The object of this paper is to study the negative impact of Internet sites on the psyche of young people, to identify the facts of unsafe use of the Internet by students leading to the development of cyber addiction and victim behavior. The article is aimed at studying the propensity for victim behavior among University students in Russia and Bulgaria and developing recommendations to shape the information security of students on the Internet in order to help reduce victim behavior. The methods of the research are: theoretical (study and analysis of psychological, pedagogical, and methodological literature on the research problem; analysis, synthesis, and generalization of empirical data; causal analysis of pedagogical experience data); empirical (questionnaire, testing, survey); methods of qualitative interpretation and data processing. The authors outlined three stages of creating a safe educational environment to prevent and correct victim behavior of students on the Internet - organizational, practical, and generalizing. The results of the research show that serious, systematic, substantial preventive and corrective work is needed to reduce student victimization, cyber addiction, and the formation of information security for students on the Internet. Teaching students to carefully perceive and critically evaluate information is one of the possible ways to create safe behavior on the Web, since ignorance of the rules of work and communication leads to rash, risky, frivolous actions on the Internet. The outlined in the research three stages of creating a safe educational environment can be used by university teachers, educational psychologists, psychologists of the rehabilitation centers and psychological and pedagogical assistance centers for prevention and correction victim behavior of students on the Internet. The data obtained and their analysis help identify students with an increased victimization background and predict their personal development, organization of prevention processes and correction of victim student behavior in the Internet. The results can be useful when developing programs for safe use of content and online sites by adolescents and youth

The use of interactive learning technologies in teaching a foreign language in high school

© 2016 Valeev et al.Modern Russian educational system is focused today on the use of interactive technologies in education. It is due to such objective factors as the possibility to enhance learning efficiency; the possibility of assimilation per unit of time more training concepts; increasing the speed of assimilation of the material; encouraging the active participation of each student in the learning process; awakening students’ interest in learning a foreign language; providing multifaceted impact on them. In this regard, in the recent researches on pedagogy and psychology it is highly recommended to use interactive technologies, which involves giving students the opportunity to individually expand and deepen their language skills, as well as forming their subject position in determining their educational path. The article reveals the essence of the use of interactive technologies in teaching a foreign language and gives structurally-substantial characteristics of this technology; grounded didactic conditions for the implementation of interactive technologies in teaching a foreign language; the content and methods of interactive learning at collaborative learning and, in general, the implementation of interactive technologies in the practice of the school. The article proposes the model of foreign language teaching methodology of the Russian high school students, due to the overall goal setting system of education in Russia, as well as the specifics of subject “Foreign Language”

Cross-Validation of Functional MRI and Paranoid-Depressive Scale: Results From Multivariate Analysis.

Introduction: There exists over the past decades a constant debate driven by controversies in the validity of psychiatric diagnosis. This debate is grounded in queries about both the validity and evidence strength of clinical measures. Materials and Methods: The objective of the study is to construct a bottom-up unsupervised machine learning approach, where the brain signatures identified by three principal components based on activations yielded from the three kinds of diagnostically relevant stimuli are used in order to produce cross-validation markers which may effectively predict the variance on the level of clinical populations and eventually delineate diagnostic and classification groups. The stimuli represent items from a paranoid-depressive self-evaluation scale, administered simultaneously with functional magnetic resonance imaging (fMRI). Results: We have been able to separate the two investigated clinical entities - schizophrenia and recurrent depression by use of multivariate linear model and principal component analysis. Following the individual and group MLM, we identified the three brain patterns that summarized all the individual variabilities of the individual brain patterns. Discussion: This is a confirmation of the possibility to achieve bottom-up classification of mental disorders, by use of the brain signatures relevant to clinical evaluation tests

A gene expression system offering multiple levels of regulation: the Dual Drug Control (DDC) system

BACKGROUND: Whether for cell culture studies of protein function, construction of mouse models to enable in vivo analysis of disease epidemiology, or ultimately gene therapy of human diseases, a critical enabling step is the ability to achieve finely controlled regulation of gene expression. Previous efforts to achieve this goal have explored inducible drug regulation of gene expression, and construction of synthetic promoters based on two-hybrid paradigms, among others. RESULTS: In this report, we describe the combination of dimerizer-regulated two-hybrid and tetracycline regulatory elements in an ordered cascade, placing expression of endpoint reporters under the control of two distinct drugs. In this Dual Drug Control (DDC) system, a first plasmid expresses fusion proteins to DBD and AD, which interact only in the presence of a small molecule dimerizer; a second plasmid encodes a cassette transcriptionally responsive to the first DBD, directing expression of the Tet-OFF protein; and a third plasmid encodes a reporter gene transcriptionally responsive to binding by Tet-OFF. We evaluate the dynamic range and specificity of this system in comparison to other available systems. CONCLUSION: This study demonstrates the feasibility of combining two discrete drug-regulated expression systems in a temporally sequential cascade, without loss of dynamic range of signal induction. The efficient layering of control levels allowed by this combination of elements provides the potential for the generation of complex control circuitry that may advance ability to regulate gene expression in vivo

Varietal reaction of potato plants grown on aeroponic installations

The article presents data on study of the productivity of potato early ripening varieties (Legenda, Russia; Red Scarlet, Netherlands) and middle-early varieties (Irbitskiy Russia; Gala, Germany) grown on aeroponic installations in artificial lighting conditions: three-tier adaptive installation (“Syntol” production) and single-tier installation produced by “Biological systems” plant. Potato plants were characterized by active growth and development. Their height ranged from 71.0 to 94.2 cm among the varieties, the number of leaves formed on one plant – from 23 to 31 pieces. The formation of mini-tubers was noted from the 46th day (Legenda variety) to the 53rd day (Irbitskiy variety). The first harvest was obtained at the 65th day in early varieties and at the 67th day for middle-early varieties beginning from planting of micro-plants on to the adaptation installation. The productivity of plants by varieties ranged from 123.0 g (Legenda) to 216.1 (Gala) g of mini-tubers per plant, output of mini tubers from 68.1 (Irbitskiy) to 105.2 (Legenda) pieces per plant, the mass of one mini-tuber ranged from 1.17(Legenda) to 2.73 g (Red Scarlet)