46 research outputs found

    Mycophenolate mofetil versus cyclosporine for remission maintenance in nephrotic syndrome

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    We performed a multi-centre randomized controlled trial to compare the efficacy of mycophenolate mofetil (MMF) to that of cyclosporine A (CsA) in treating children with frequently relapsing nephrotic syndrome and biopsy-proven minimal change disease. Of the 31 randomized initially selected patients, seven were excluded. The remaining 24 children received either MMF 1200 mg/m2per day (n = 12) or CsA 4-5 mg/kg per day (n = 12) during a 12-month period. Of the 12 patients in the MMF group, two discontinued the study medication. Evaluation of the changes from the baseline glomerular filtration rate showed an overall significant difference in favour of MMF over the treatment period (p = 0.03). Seven of the 12 patients in the MMF group and 11 of the 12 patients in the CsA group remained in complete remission during the entire study period. Relapse rate in the MMF group was 0.83/year compared to 0.08/year in the CsA group (p = 0.08). None of the patients reported diarrhea. Pharmacokinetic profiles of mycophenolic acid were performed in seven patients. The patient with the lowest area under the curve had three relapses within 6 months. In children with frequently relapsing minimal change nephrotic syndrome, MMF has a favourable side effect profile compared to CsA; however, there is a tendency towards a higher relapse risk in patients treated with MMF

    A Novel Mass Hierarchy and Discrete Excitation Spectra from Quantum-Fluctuating D-branes

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    We elaborate further on a recently proposed scenario for generating a mass hierarchy through quantum fluctuations of a single D3 brane, which represents our world embedded in a bulk five-dimensional space time. In this scenario, the quantum fluctuations of the D3-brane world in the bulk direction, quantified to leading order via a `recoil' world-sheet logarithmic conformal field theory approach, result in the dynamical appearance of a supersymmetry breaking (obstruction) scale alpha. This may be naturally taken to be at the TeV range, in order to provide a solution to the conventional gauge-hierarchy problem. The bulk spatial direction is characterized by the dynamical appearance of an horizon located at +- 1/alpha, inside which the positive energy conditions for the existence of stable matter are satisfied. To ensure the correct value of the four-dimensional Planck mass, the bulk string scale M_s is naturally found to lie at an intermediate energy scale of 10^{14} GeV. As an exclusive feature of the D3-brane quantum fluctuations (`recoil') we find that, for any given M_5, there is a discrete mass spectrum for four-dimensional Kaluza-Klein (KK) modes of bulk graviton and/or scalar fields. KK modes with masses 0 <= m < sqrt{2}alpha << M_s are found to have wavefunctions peaked, and hence localized, on the D3 brane at z=0.Comment: 21 pages latex, three eps figures incorporate
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