Hirshfeld Surface Analysis and Crystal Structure of [2-Bromo-4-(4-Fluoro-Benzoyl)-Phenoxy]-Acetic Acid Ethyl Ester

The title compound C17H14BrFO4 was synthesized using 3-Bromo-4-hydroxy-phenyl-(4-fluoro-phenyl)-methanone, ethyl chloroacetate, and anhydrous potassium carbonate. Its structure was established using elemental analysis, NMR, and single crystal X-ray diffraction techniques. The compound crystallizes in orthorhombic crystal system and space group Pbca. The cell parameters are a = 10.1444(13) Å, b = 8.2781(10) Å, c = 38.423(5) Å, Z = 8, V = 3226.6(7) Å3. The dihedral angle between two least squares planes of two phenyl rings bridged by keto carbonyl group is −28.2(5)°. The molecule exhibits intermolecular interactions of the type C‒H…F and C‒H…O. The intercontacts in the crystal structure ar

Synthesis, characterization, and antibacterialactivity of 6-Chloro-8-methyl-2-oxo-2H-chromene-3-carboxylic acid ethyl ester

The title compound was synthesized by reacting 2-hydroxy-4-methoxy-benzaldehyde with diethyl malonate in the presence of piperidine cat-alyst and ethanol as solvent. The chemical structure of the title com-pound was elucidated by elemental analysis,1H-NMR, and IR. The crys-tal structure was determined by X-ray diffraction data. It crystallizes inmonoclinic crystal system, P21/c space group with unit cell parameters,a=12.840(2) ̊A, b=24.790(4) ̊A, c=7.8544(13) ̊A,β=98.035(5)°,V=2475.5(7) ̊A3,andZ=8. The molecular and crystal structure of the titlecompound is stabilized by inter- and intramolecular interactions of thetype C—H···O. The newly synthesized compound was screened for itsantibacterial activity against two gram-positive and two gram-negativebacteria