Concert recording 2019-03-06

[Track 1]. A place in this world / Taylor Swift -- [Track 2]. Alone / Heart -- [Track 3]. Baby Love / The Supremes -- [Track 4]. Before he cheats / Carrie Underwood -- [Track 5]. A case of you / Joni Mitchell -- [Track 6]. I hate love songs / Kelsea Ballerini -- [Track 7]. Jolene / Dolly Parton -- [Track 8]. Once upon another time / Sara Bareilles -- [Track 9]. Rhiannon / Fleetwood Mac -- [Track 10]. Say a little prayer for you / Aretha Franklin -- [Track 11]. Single ladies / Beyoncé -- [Track 12]. Sk8r boi / Avril Lavigne -- [Track 13]. Take it all / Adele -- [Track 14]. Valerie / Amy Winehouse -- [Track 15]. You make me feel like a natural woman / Aretha Franklin -- [Track 16]. You needed me / Anne Murray

A versatile injection system for flow-injection analysis

Analyser injection systems based on the principle of flow-injection analysis depend on the technique used. They generally take the form of an injection loop valve; the injected sample volume is determined by the volume of the valve. Injection systems are seldom designed with a time factor to define this volume. The authors report on an original injection system, which enables the two techniques to be used. The paper describes the evaluation of this system using both injection techniques and the comparison between them. The results show good linearity (r = 0.999 to 1.000) and an average precision (CV = 1.04 to 1.51%) for the volume-based injection technique; (ii) good linearity (r = 1.000) and better precision (CV = 0.73 to 1.30%) for the time-based injection technique. The system can be used equally well by the loop and by the clock; however, the latter is preferable because of its practicability

Prevalence and risk factors of cancer-related fatigue in childhood cancer survivors: A DCCSS LATER study

BACKGROUND: Cancer-related fatigue is a debilitating late effect after treatment for childhood cancer. The prevalence of fatigue in childhood cancer survivors (CCSs) and associated factors for fatigue has varied widely in previous studies. Two important aspects of cancer-related fatigue, its severity and chronicity, are often not assessed. This study investigated the prevalence of, and risk factors for, severe chronic fatigue (CF) in a national cohort of Dutch CCSs. METHODS: In this study, 2810 CCSs (5-year survivors of all childhood malignancies diagnosed between 1963 and 2001 with a current age of 12-65 years) and 1040 sibling controls were included. CF was assessed with the Short Fatigue Questionnaire and was defined as a score ≥ 18 and persistence of fatigue for ≥6 months. Cancer- and treatment-related characteristics, current health problems, and demographic and lifestyle variables were assessed as potential risk factors for CF via multivariable logistic regression analyses. RESULTS: In adult CCSs and sibling controls (≥18 years old), the prevalence of CF was 26.1% and 14.1%, respectively (P 2, 2.20; 95% CI, 1.50-3.21), and a central nervous system diagnosis (OR, 1.74; 95% CI, 1.17-2.60) were significantly associated with CF in adult CCSs. CONCLUSIONS: This study shows that CCSs, regardless of their cancer diagnosis, report CF more often than sibling controls. This study provides new evidence for the prevalence of fatigue in CCSs

Pedagogy of belonging: Cultivating wellbeing literacy in higher education

Wellbeing literacy is the capability to set intentions and comprehend and compose wellbeing language. This is cultivated and embodied across contexts with the intention of maintaining or improving the wellbeing of oneself, others, or the world. In this paper, as co-authors we share the way we understand our wellbeing as educators in higher education, that is, through a Pedagogy of Belonging. Belonging is one of the domains to our wellbeing as academics and educators, as well as students in the studied higher education learning context. Pedagogy of Belonging helps us develop our wellbeing literacy individually and collectively. Through an authentic inquiry framed by hermeneutic phenomenology, we highlight four vignettes, showcasing what this looks like across different disciplines located in one school of an Australian university. In these vignettes, we look at what it means to engage with diverse areas of wellbeing that enhance our collective capacity to flourish. We have paused, listening deeply to our academic and wellbeing needs, addressing these together to develop a shared language that supports our wellbeing. We describe the valuing of meaning, curiosity associated with relationship building, multi-modal ways of being with each other, passion, and positive emotions that promote academic wellbeing capabilities that, in turn, support, develop, and sustain a wellbeing literacy. In demonstrating how a wellbeing literacy can be developed, maintained, and/or improved, we open new avenues of investigation that interrupt the dehumanising of higher education learning contexts

Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER): a cross-sectional study

Background: Childhood cancer survivors appear to be at increased risk of frailty and sarcopenia, but evidence on the occurrence of and high-risk groups for these aging phenotypes is scarce, especially in European survivors. The aim of this cross-sectional study was to assess the prevalence of and explore risk factors for pre-frailty, frailty, and sarcopenia in a national cohort of Dutch childhood cancer survivors diagnosed between 1963 and 2001. Methods: Eligible individuals (alive at the time of study, living in the Netherlands, age 18–45 years, and had not previously declined to participate in a late-effects study) from the Dutch Childhood Cancer Survivor Study (DCCSS-LATER) cohort were invited to take part in this cross-sectional study. We defined pre-frailty and frailty according to modified Fried criteria, and sarcopenia according to the European Working Group on Sarcopenia in Older People 2 definition. Associations between these conditions and demographic and treatment-related as well as endocrine and lifestyle-related factors were estimated with two separate multivariable logistic regression models in survivors with any frailty measurement or complete sarcopenia measurements. Findings: 3996 adult survivors of the DCCSS-LATER cohort were invited to participate in this cross-sectional study. 1993 non-participants were excluded due to lack of response or a decline to participate and 2003 (50·1%) childhood cancer survivors aged 18–45 years were included. 1114 (55·6%) participants had complete frailty measurements and 1472 (73·5%) participants had complete sarcopenia measurements. Mean age at participation was 33·1 years (SD 7·2). 1037 (51·8%) participants were male, 966 (48·2%) were female, and none were transgender. In survivors with complete frailty measurements or complete sarcopenia measurements, the percentage of pre-frailty was 20·3% (95% CI 18·0–22·7), frailty was 7·4% (6·0–9·0), and sarcopenia was 4·4% (3·5–5·6). In the models for pre-frailty, underweight (odds ratio [OR] 3·38 [95% CI 1·92–5·95]) and obesity (OR 1·67 [1·14–2·43]), cranial irradiation (OR 2·07 [1·47–2·93]), total body irradiation (OR 3·17 [1·77–5·70]), cisplatin dose of at least 600 mg/m2 (OR 3·75 [1·82–7·74]), growth hormone deficiency (OR 2·25 [1·23–4·09]), hyperthyroidism (OR 3·72 [1·63–8·47]), bone mineral density (Z score ≤–1 and >–2, OR 1·80 [95% CI 1·31–2·47]; Z score ≤–2, OR 3·37 [2·20–5·15]), and folic acid deficiency (OR 1·87 [1·31–2·68]) were considered significant. For frailty, associated factors included age at diagnosis between 10–18 years (OR 1·94 [95% CI 1·19–3·16]), underweight (OR 3·09 [1·42–6·69]), cranial irradiation (OR 2·65 [1·59–4·34]), total body irradiation (OR 3·28 [1·48–7·28]), cisplatin dose of at least 600 mg/m2 (OR 3·93 [1·45–10·67]), higher carboplatin doses (per g/m2; OR 1·15 [1·02–1·31]), cyclophosphamide equivalent dose of at least 20 g/m2 (OR 3·90 [1·65–9·24]), hyperthyroidism (OR 2·87 [1·06–7·76]), bone mineral density Z score ≤–2 (OR 2·85 [1·54–5·29]), and folic acid deficiency (OR 2·04 [1·20–3·46]). Male sex (OR 4·56 [95%CI 2·26–9·17]), lower BMI (continuous, OR 0·52 [0·45–0·60]), cranial irradiation (OR 3·87 [1·80–8·31]), total body irradiation (OR 4·52 [1·67–12·20]), hypogonadism (OR 3·96 [1·40–11·18]), growth hormone deficiency (OR 4·66 [1·44–15·15]), and vitamin B12 deficiency (OR 6·26 [2·17–1·81]) were significantly associated with sarcopenia. Interpretation: Our findings show that frailty and sarcopenia occur already at a mean age of 33 years in childhood cancer survivors. Early recognition and interventions for endocrine disorders and dietary deficiencies could be important in minimising the risk of pre-frailty, frailty, and sarcopenia in this population. Funding: Children Cancer-free Foundation, KiKaRoW, Dutch Cancer Society, ODAS Foundation

Increased health-related quality of life impairments of male and female survivors of childhood cancer: DCCSS LATER 2 psycho-oncology study

Background: The objective of this study was to compare the health-related quality of life (HRQOL) of Dutch adult male and female childhood cancer survivors (CCSs) to general population references and to study medical determinants. Methods: CCSs from the Dutch Childhood Cancer Survivor Study LATER cohort (1963-2001) part 2, who were 18 years old or older (time since diagnosis ≥ 5 years), were invited to complete the TNO-AZL Questionnaire for Adult Health-Related Quality of Life. Domain scores and proportions of CCSs with impaired HRQOL (score 1.4. In addition, female CCSs were more often impaired in daily activities, pain, and sexuality (ORs, 1.4-1.9) and were less often aggressive (OR, 0.6). CCCs of central nervous system (CNS) tumors, bone tumors, and retinoblastoma and those with cranial, abdominopelvic, or lower extremity radiotherapy were at increased risk of impairment in 1 or more domains. Conclusions: Dutch adult CCSs, especially females, have impaired HRQOL in several domains; this is most pronounced in cognitive functioning. The vulnerabilities of subgroups at risk, such as CCSs of CNS tumors, were confirmed. Surveillance of HRQOL and multidisciplinary survivor care are recommended. Lay Summary: The health-related quality of life in a Dutch nationwide cohort of 1766 survivors of childhood cancer was studied. Survivors of childhood cancer were found to have lower health-related quality of life in several domains (eg, motor functioning and vitality) in comparison with the general population. They most often reported low cognitive functioning (eg, memory and attention). Females had low health-related quality of life in more domains than males. Survivors of brain tumors had low health-related quality of life in most domains. Monitoring health-related quality of life regularly and collaborating between disciplines in survivor care is recommended

Clinical and self-reported markers of reproductive function in female survivors of childhood Hodgkin lymphoma

PURPOSE: To evaluate the impact of treatment for Hodgkin lymphoma (HL) on clinical reproductive markers and pregnancy outcomes. METHODS: This study was embedded within the DCOG LATER-VEVO study; a Dutch, multicenter, retrospective cohort study between 2004 and 2014. Serum anti-Müllerian hormone (AMH), follicle stimulating hormone (FSH), inhibin B, antral follicle count (AFC), and self-reported (first) pregnancy outcomes were evaluated in female childhood HL survivors and controls. RESULTS: 84 HL survivors and 798 controls were included, aged 29.6 and 32.7 years old at time of assessment. Median age at HL diagnosis was 13.4 years. Cyclophosphamide equivalent dose (CED-score) exceeded 6000 mg/m 2 in 56 women and 14 survivors received pelvic irradiation. All clinical markers were significantly deteriorated in survivors (odds-ratio for low AMH ( 10 IU/l) 15.3 [95% CI 5.7; 41.1], low Inhibin B ( 12 months was 2.5 [95% CI 1.1; 5.6] in survivors, p = 0.031. Adverse outcomes were specifically present after treatment with procarbazine and higher CED-score. CONCLUSION: HL survivors appear to have an impaired ovarian reserve. However, chance to achieve pregnancy seems reassuring at a young age. Additional follow-up studies are needed to assess fertile life span and reproductive potential of HL survivors, in particular for current HL treatments that are hypothesized to be less gonadotoxic

Extensive Cardiac Function Analyses Using Contemporary Echocardiography in Childhood Cancer Survivors: A DCCSS LATER Study

Background: Childhood cancer survivors (CCS) are at risk for cardiotoxicity. Objectives: We sought to assess how cardiac dysfunction measurements in CCS overlap and are differentially influenced by risk factors. Methods: This cross-sectional Dutch Childhood Cancer Survivor Study evaluated echocardiograms of 1,397 ≥5-year CCS and 277 siblings. Of CCS, n = 1,254 received cardiotoxic (anthracyclines/mitoxantrone/radiotherapy involving the heart region [RTheart]) and n = 143 received potentially cardiotoxic (cyclophosphamide, ifosfamide, or vincristine) therapy. We assessed demographic, treatment-related, and traditional cardiovascular risk factors for cardiac dysfunction using multivariable logistic regression. Results: CCS were a median of 26.7 years after diagnosis; 49% were women. Abnormal left ventricular ejection fraction (LVEF) (defined as <52% in men, <54% in women) occurred most commonly in CCS treated with anthracyclines and RTheart combined (38%). Age/sex-specific abnormal global longitudinal strain (GLS) occurred most commonly in CCS treated with RTheart, either with (41%) or without (38%) anthracyclines. Of CCS with normal LVEF, 20.2% showed abnormal GLS. Diastolic dysfunction grade ≥II was rare. Abnormal LVEF was mainly associated with female sex, anthracycline dose, and only in women, RTheart dose. Abnormal GLS was associated with female sex, RTheart dose, diastolic blood pressure, and only in women, anthracycline dose. Cyclophosphamide, ifosfamide, and vincristine were not associated with LVEF or GLS. Compared with siblings, CCS showed higher risk of abnormal LVEF (OR: 2.9; 95% CI: 1.4-6.6) and GLS (OR: 2.1; 95% CI: 1.2-3.7), independent of (potentially) cardiotoxic treatment-related and cardiovascular risk factors. Conclusions: Abnormal LVEF and GLS constitute complementary measures of systolic dysfunction among long-term CCS. Their diagnostic value may differ according to cardiotoxic exposures. Also, CCS have residual, unexplained risk of cardiac dysfunction

Fraternity Exit Process: A Look At Fraternity Members Moving Out of the Chapter House

The process of leaving a work organization is difficult. Leaving an organization that you are part of as a volunteer is just as difficult. In fraternities, upperclassmen members tend to move out one year before they graduate. This is a problem that can create a leadership gap in the chapter and presents a financial burden on many chapters. This study aims to find out why members in the fraternity system (a volunteer organization) at a large west coast university move out of their chapter house before they graduate, how their exit process is different from traditional work organizational exit, and how the chapter views the exiting member. This thesis answers these questions by applying the exit process theories of Fredric Jablin and Helen Ebaugh, along with the Narrative Paradigm of Walter Fisher and Self-Authorship Theory by Marcia Magolda. Through a series of interviews and a focus group it was determined that fraternity members leave for five different reason, their exit is different because of the continued participation after exit, and that the chapter views the exiting members as either negative or neutral. The results of this thesis add to the growing research area of volunteer organizational communication