Concert recording 2019-03-06

[Track 1]. A place in this world / Taylor Swift -- [Track 2]. Alone / Heart -- [Track 3]. Baby Love / The Supremes -- [Track 4]. Before he cheats / Carrie Underwood -- [Track 5]. A case of you / Joni Mitchell -- [Track 6]. I hate love songs / Kelsea Ballerini -- [Track 7]. Jolene / Dolly Parton -- [Track 8]. Once upon another time / Sara Bareilles -- [Track 9]. Rhiannon / Fleetwood Mac -- [Track 10]. Say a little prayer for you / Aretha Franklin -- [Track 11]. Single ladies / Beyoncé -- [Track 12]. Sk8r boi / Avril Lavigne -- [Track 13]. Take it all / Adele -- [Track 14]. Valerie / Amy Winehouse -- [Track 15]. You make me feel like a natural woman / Aretha Franklin -- [Track 16]. You needed me / Anne Murray

A versatile injection system for flow-injection analysis

Analyser injection systems based on the principle of flow-injection analysis depend on the technique used. They generally take the form of an injection loop valve; the injected sample volume is determined by the volume of the valve. Injection systems are seldom designed with a time factor to define this volume. The authors report on an original injection system, which enables the two techniques to be used. The paper describes the evaluation of this system using both injection techniques and the comparison between them. The results show good linearity (r = 0.999 to 1.000) and an average precision (CV = 1.04 to 1.51%) for the volume-based injection technique; (ii) good linearity (r = 1.000) and better precision (CV = 0.73 to 1.30%) for the time-based injection technique. The system can be used equally well by the loop and by the clock; however, the latter is preferable because of its practicability

Strategies for improving mental health and wellbeing used by older people living with HIV: A qualitative investigation

Recent research into “successful ageing” and “resilience” in the context of ageing with HIV highlights older people living with HIV’s (OPLWH) adaptations and coping strategies hitherto neglected by early research’s emphasis on difficulties and challenges. Yet “resilience” and “successful ageing” are limited by their inconsistent definition, conflation of personal traits and coping strategies, normative dimension, and inattention to cultural variation and the distinctive nature of older age. This article thus adopts an interpretivist approach to how OPLWH manage the challenges to their mental health and wellbeing of ageing with HIV. Drawing on interviews with 76 OPLWH (aged 50+) living in the United Kingdom, we document both the strategies these participants use (for example, “accentuating the positive” and accessing external support) and the challenges to these strategies’ success posed by the need to manage their HIV’s social and clinical dimensions and prevent their HIV from dominating their lives. This points to (a) the complex overlaps between challenges to and strategies for improving or maintaining mental health and wellbeing in the context of ageing with HIV, and (b) the limitations of the “resilience” and “successful ageing” approaches to ageing with HIV. Ageing, HIV, resilience, successful ageing, mental health strategies, wellbeing, interpretivist approach

Antifibrinolytics attenuate inflammatory gene expression after cardiac surgery

ObjectivesAnti-inflammatory effects of tranexamic acid and aprotinin, used to abate perioperative blood loss, are reported and might be of substantial clinical relevance. The study of messenger ribonucleic acid synthesis provides a valuable asset in evaluating the inflammatory pathways involved.MethodsWhole-blood messenger ribonucleic acid expression of 114 inflammatory genes was compared pre- and postoperatively in 35 patients randomized to receive either placebo, tranexamic acid, or aprotinin. These results were further confirmed by reverse transcription–polymerase chain reaction.ResultsOf the 23 genes exhibiting independently altered postoperative gene expression levels, 8 were restricted to the aprotinin group only (growth differentiation factor 3, interleukin 19, interleukin 1 family member 7, transforming growth factor α, tumor necrosis factor superfamily 10, tumor necrosis factor superfamily 12, tumor necrosis factor superfamily 13B, vascular endothelial growth factor α), whereas both aprotinin and tranexamic acid altered gene expression of 3 genes as compared with placebo (FMS-related tyrosine kinase 3 ligand, growth differentiation factor 5, interferon-α8). In general, less upregulation of pro-inflammatory, and more upregulation of anti-inflammatory, genes was observed for patients treated with antifibrinolytics. Gene expression affected by aprotinin coded mostly for proteins that function through serine proteases.ConclusionsThis study demonstrates that the use of tranexamic acid and aprotinin results in altered inflammatory pathways on the genomic expression level. We further demonstrate that the use of aprotinin leads to significant attenuation of the immune response, with several inhibitory effects restricted to the use of aprotinin only. The results aid in a better understanding of the targets of these drugs, and add to the discussion on which antifibrinolytic can best be used in the cardiac surgical patient

Effect of Constitution on Mass of Individual Organs and Their Association with Metabolic Rate in Humans—A Detailed View on Allometric Scaling

Resting energy expenditure (REE)-power relationships result from multiple underlying factors including weight and height. In addition, detailed body composition, including fat free mass (FFM) and its components, skeletal muscle mass and internal organs with high metabolic rates (i.e. brain, heart, liver, kidneys), are major determinants of REE. Since the mass of individual organs scales to height as well as to weight (and, thus, to constitution), the variance in these associations may also add to the variance in REE. Here we address body composition (measured by magnetic resonance imaging) and REE (assessed by indirect calorimetry) in a group of 330 healthy volunteers differing with respect to age (17–78 years), sex (61% female) and BMI (15.9–47.8 kg/m2). Using three dimensional data interpolation we found that the inter-individual variance related to scaling of organ mass to height and weight and, thus, the constitution-related variances in either FFM (model 1) or kidneys, muscle, brain and liver (model 2) explained up to 43% of the inter-individual variance in REE. These data are the first evidence that constitution adds to the complexity of REE. Since organs scale differently as weight as well as height the “fit” of organ masses within constitution should be considered as a further trait

児童期までの食事経験がその後の家族関係に及ぼす影響について : 家族イメージ法を用いて

本研究は、大学生の児童期までの食事経験が現在の家族関係にどのような影響を及ぼすのかを検討する目的で行われた。食事経験に関する項目として「大学生が認知した過去の食事場面の状況に関する項目」、現在の家族関係に関する尺度として「家族機能測定尺度」、「家族イメージ法」を用いて、大学生199名を対象に実施した。「大学生の認知した過去の食事場面の項目」を因子分析した結果、「料理への配慮」、「料理の簡便性」、「相互交流」、「雰囲気のよさ」、「しつけ・マナー」の5因子が抽出された。また、家族機能測定尺度の因子分析の結果、「凝集性」、「適応性」の2因子が抽出された。重回帰分析の結果、「凝集性」、「適応性」にはともに「雰囲気のよさ」、「相互交流」において有意差がみられた。また、「子の濃さ」、「母子の結びつきの強さ」、「父子の結びつきの強さ」は「雰囲気のよさ」に有意差がみられた。先行研究の報告と同様に、過去の家族との食事の「雰囲気のよさ」は改めて重要であることが確認された。食事場面では、単なる会話だけをする場ではなく雰囲気を楽しむことが大切である。しかし、この雰囲気のよさは一体何に規定されるのかは明らかにすることが今後の課題として挙げられた

Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes

The second plague pandemic, caused by Yersinia pestis, devastated Europe and the nearby regions between the 14th and 18th centuries AD. Here we analyse human remains from ten European archaeological sites spanning this period and reconstruct 34 ancient Y. pestis genomes. Our data support an initial entry of the bacterium through eastern Europe, the absence of genetic diversity during the Black Death, and low within-outbreak diversity thereafter. Analysis of post-Black Death genomes shows the diversification of a Y. pestis lineage into multiple genetically distinct clades that may have given rise to more than one disease reservoir in, or close to, Europe. In addition, we show the loss of a genomic region that includes virulence-related genes in strains associated with late stages of the pandemic. The deletion was also identified in genomes connected with the first plague pandemic (541–750 AD), suggesting a comparable evolutionary trajectory of Y. pestis during both events

Self-oscillation

Physicists are very familiar with forced and parametric resonance, but usually not with self-oscillation, a property of certain dynamical systems that gives rise to a great variety of vibrations, both useful and destructive. In a self-oscillator, the driving force is controlled by the oscillation itself so that it acts in phase with the velocity, causing a negative damping that feeds energy into the vibration: no external rate needs to be adjusted to the resonant frequency. The famous collapse of the Tacoma Narrows bridge in 1940, often attributed by introductory physics texts to forced resonance, was actually a self-oscillation, as was the swaying of the London Millennium Footbridge in 2000. Clocks are self-oscillators, as are bowed and wind musical instruments. The heart is a "relaxation oscillator," i.e., a non-sinusoidal self-oscillator whose period is determined by sudden, nonlinear switching at thresholds. We review the general criterion that determines whether a linear system can self-oscillate. We then describe the limiting cycles of the simplest nonlinear self-oscillators, as well as the ability of two or more coupled self-oscillators to become spontaneously synchronized ("entrained"). We characterize the operation of motors as self-oscillation and prove a theorem about their limit efficiency, of which Carnot's theorem for heat engines appears as a special case. We briefly discuss how self-oscillation applies to servomechanisms, Cepheid variable stars, lasers, and the macroeconomic business cycle, among other applications. Our emphasis throughout is on the energetics of self-oscillation, often neglected by the literature on nonlinear dynamical systems.Comment: 68 pages, 33 figures. v4: Typos fixed and other minor adjustments. To appear in Physics Report