"Origo Constantini Imperatoris": comentario, notas y traducción

El objetivo de este artículo no es otro que presentar por primera vez una traducción al castellano de la "Origo Constantini Imperatoris", texto del s. IV dedicado a la vida y trayectoria política del emperador Constantino el Grande. Dicha traducción se presenta acompañada de un breve comentario histórico y literario con el que se pretende dar una visión global del estado actual de las investigaciones que esta obra ha generado.The aim of this paper is, basically, to present for the first time a Spanish translation of the "Origo Constantini Imperatoris". This is a text belonging to the 4th century, dedicated to Constantine the Great’s life and political course. The above mentioned translation is presented enclosed to a brief historic and literary commentary. It aims to give a general view of the current state of investigations that this work has generated.España. Ministerio de Educación y Ciencia AP20045943Aragón (Comunidad Autónoma) B037/200

The Distribution of X-ray Dips with Orbital Phase in Cygnus X-1

We present results of a comprehensive study of the distribution of absorption dips with orbital phase in Cygnus X-1. Firstly, the distribution was obtained using archival data from all major X-ray observatories and corrected for the selection effect that phase zero (superior conjunction of the black hole) has been preferentially observed. Dip occurrence was seen to vary strongly with orbital phase \phi, with a peak at \phi ~ 0.95, i.e. was not symmetric about phase zero. Secondly, the RXTE ASM has provided continuous coverage of the Low State of Cygnus X-1 since Sept. 1996, and we have selected dip data based on increases in hardness ratio. The distribution, with much increased numbers of dip events, confirms that the peak is at \phi ~ 0.95, and we report the discovery of a second peak at \phi ~ 0.6. We attribute this peak to absorption in an accretion stream from the companion star HDE 226868. We have estimated the ionization parameter at different positions showing that radiative acceleration of the wind is suppressed by photoionization in particular regions in the binary system. To obtain the variation of column density with phase, we make estimates of neutral wind density for the extreme cases that acceleration of the wind is totally suppressed, or not suppressed at all. An accurate description will lie between these extremes. In each case, a strong variation of column density with orbital phase resulted, similar to the variation of dip occurrence. This provides evidence that formation of the blobs in the wind which lead to absorption dips depends on the density of the neutral component in the wind, suggesting possible mechanisms for blob growth.Comment: 9 pages, Latex, 7 ps figures. accepted by MNRA

The Role of Family Interactions in HIV Risk for Gay and Bisexual Male Youth: A Pilot Study

Despite ongoing prevention efforts, young gay and bisexual males continue to engage in sexual behaviors that place them at disproportionately high risk for HIV infection. Parental monitoring and parent-child communication have been found to be associated with low-risk sexual behavior among heterosexual youth, but the role of family interactions for gay and bisexual male youth remains largely unexplored. To help address this gap, an exploratory study of recorded and coded interactions among 35 gay and bisexual youth and their parents was done to begin to identify which types of family interactions were associated with youth high-risk sexual behavior. Parent-son communication that was mutual and low in conflict was found to be most prevalent among youth with the fewest reported high-risk sexual behaviors. These preliminary findings, along with a case example, demonstrate how social workers can coach families to engage in productive and potentially influential interactions that reduce HIV-related sexual behaviors among young gay and bisexual males

Novel patient-centered approach to facilitate same-day discharge in patients undergoing elective percutaneous coronary intervention

Background Same‐day discharge ( SDD ) after elective percutaneous coronary intervention is safe, less costly, and preferred by patients, but it is usually performed in low‐risk patients, if at all. To increase the appropriate use of SDD in more complex patients, we implemented a “patient‐centered” protocol based on risk of complications at Barnes‐Jewish Hospital. Methods and Results Our objectives were as follows: (1) to evaluate time trends in SDD ; (2) to compare (a) mortality, bleeding, and acute kidney injury, (b) patient satisfaction, and (c) hospital costs by SDD versus no SDD ( NSDD ); and (3) to compare SDD eligibility by our patient‐centered approach versus Society for Cardiovascular Angiography and Interventions guidelines. Our patient‐centered approach was based on prospectively identifying personalized bleeding, mortality, and acute kidney injury risks, with a personalized safe contrast limit and mitigating those risks. We analyzed Barnes‐Jewish Hospital's National Cardiovascular Data Registry Cath PCI Registry data from July 1, 2009 to September 30, 2015 (N=1752). SDD increased rapidly from 0% to 77% ( P &lt;0.001), independent of radial access. Although SDD patients were comparable to NSDD patients, SDD was not associated with adverse outcomes (0% mortality, 0% bleeds, and 0.4% acute kidney injury). Patient satisfaction was high with SDD . Propensity score–adjusted costs were 7331 lower/ SDD patient ( P <0.001), saving an estimated 1.8 million annually. Only 16 patients (6.95%) met the eligibility for SDD by Society for Cardiovascular Angiography and Interventions guidelines, implying our patient‐centered approach markedly increased SDD eligibility. Conclusions With a patient‐centered approach, SDD rapidly increased and was safe in 75% of patients undergoing elective percutaneous coronary intervention, despite patient complexity. Patient satisfaction was high, and hospital costs were lower. Patient‐centered decision making to facilitate SDD is an important opportunity to improve the value of percutaneous coronary intervention. </jats:sec

CME/SAM Pathology Consultation on Detection of Clostridium difficile

A b s t r a c t Consult Questions Many new laboratory methods have been developed recently for the detection of Clostridium difficile, including several commercially available molecular assays. This pathology consultation focuses on clinical laboratory testing for C difficile in the context of the following questions: • How do currently available C difficile detection methods compare in terms of sensitivity, specificity, and costefficiency? • What are some common issues related to C difficile testordering practices, and should these be monitored or mandated by clinical laboratory professionals

Both 3,3′,5-triiodothyronine and 3,5-diodo-L-thyronine are able to repair mitochondrial DNA damage but by different mechanisms

This study evaluated the effect of 3,5-diiodo-L-thyronine (T2) and 3,5,3′-triiodo-L-thyronine (T3) on rat liver mitochondrial DNA (mtDNA) oxidative damage and repair and to investigate their ability to induce protective effects against oxidative stress. Control rats, rats receiving a daily injection of T2 (N+T2) for 1 week and rats receiving a daily injection of T3 (N+T3) for 1 week, were used throughout the study. In the liver, mtDNA oxidative damage [by measuring mtDNA lesion frequency and expression of DNA polymerase γ (POLG)], mtDNA copy number, mitochondrial biogenesis [by measuring amplification of mtDNA/nDNA and expression of peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α)], and oxidative stress [by measuring serum levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG)] were detected. T2 reduces mtDNA lesion frequency and increases the expression of POLG, and it does not change the mtDNA copy number, the expression of PGC-1α, or the serum levels of 8-OHdG. Therefore, T2, by stimulating the major mtDNA repair enzyme, maintains genomic integrity. Similar to T2, T3 decreases mtDNA lesion frequency but increases the serum levels of 8-OHdG, and it decreases the expression of POLG. Moreover, as expected, T3 increases the mtDNA copy number and the expression of PGC-1α. Thus, in T3-treated rats, the increase of 8-OHdG and the decrease of POLG indicate that there is increased oxidative damage and that the decreased mtDNA lesion frequency might be a consequence of increased mitochondrial biogenesis. These data demonstrate that both T2 and T3 are able to decrease in the liver mtDNA oxidative damage, but they act via different mechanisms