154 research outputs found
Magnetization steps in Zn_(1-x)Mn_xO: Four largest exchange constants and single-ion anisotropy
Magnetization steps (MST's) from Mn pairs in several single crystals of
Zn_(1-x)Mn_xO (0.0056<=x<=0.030, and in one powder (x=0.029), were observed.
The largest two exchange constants, J1/kB=-18.2+/-0.5K and J1'/kB=-24.3+/-0.6K,
were obtained from large peaks in the differential susceptibility, dM/dH,
measured in pulsed magnetic fields, H, up to 500 kOe. These two largest J's are
associated with the two inequivalent classes of nearest neighbors (NN's) in the
wurtzite structure. The 29% difference between J1 and J1' is substantially
larger than 13% in CdS:Mn, and 15% in CdSe:Mn. The pulsed-field data also
indicate that, despite the direct contact between the samples and a
superfluid-helium bath, substantial departures from thermal equilibrium
occurred during the 7.4 ms pulse. The third- and fourth-largest J's were
determined from the magnetization M at 20 mK, measured in dc magnetic fields H
up to 90 kOe. Both field orientations H||c and H||[10-10] were studied. (The
[10-10] direction is perpendicular to the c-axis, [0001].) By definition,
neighbors which are not NN's are distant neighbors (DN's). The largest DN
exchange constant (third-largest overall), has the value J/kB=-0.543+/-0.005K,
and is associated with the DN at r=c. Because this is not the closest DN, this
result implies that the J's do not decrease monotonically with the distance r.
The second-largest DN exchange constant (fourth-largest overall), has the value
J/kB=-0.080 K. It is associated with one of the two classes of neighbors that
have a coordination number z=12, but the evidence is insufficient for a
definite unique choice. The dependence of M on the direction of H gives
D/kB=-0.039+/-0.008K, in fair agreement with -0.031 K from earlier EPR work.Comment: 12 pages, 10 figures. Submitted to PR
Spin relaxation and antisymmetric exchange in n-doped III-V semiconductor
Recently K. Kavokin [Phys. Rev. B 64, 075305 (2001)] suggested that the
Dzyaloshinskii-Moriya interaction between localized electrons governs slow spin
relaxation in -doped GaAs in the regime close to the metal-insulator
transition. We derive the correct spin Hamiltonian and apply it to the
determination of spin dephasing time using the method of moments expansion. We
argue that the proposed mechanism is insufficient to explain the observed
values of the spin relaxation time.Comment: 5 pages, 1 figure
Anisotropic exchange interaction of localized conduction-band electrons in semiconductor structures
The spin-orbit interaction in semiconductors is shown to result in an
anisotropic contribution into the exchange Hamiltonian of a pair of localized
conduction-band electrons. The anisotropic exchange interaction exists in
semiconductor structures which are not symmetric with respect to spatial
inversion, for instance in bulk zinc-blend semiconductors. The interaction has
both symmetric and antisymmetric parts with respect to permutation of spin
components. The antisymmetric (Dzyaloshinskii-Moriya) interaction is the
strongest one. It contributes significantly into spin relaxation of localized
electrons; in particular, it governs low-temperature spin relaxation in n-GaAs
with the donor concentration near 10^16cm-3. The interaction must be allowed
for in designing spintronic devices, especially spin-based quantum computers,
where it may be a major source of decoherence and errors
Spin interactions of interstitial Mn ions in ferromagnetic GaMnAs
The recently reported Rutherford backscattering and particle-induced X-ray
emission experiments have revealed that in low-temperature MBE grown GaMnAs a
significant part of the incorporated Mn atoms occupies tetrahedral interstitial
sites in the lattice. Here we study the magnetic properties of these
interstitial ions. We show that they do not participate in the hole-induced
ferromagnetism. Moreover, Mn interstitial double donors may form pairs with the
nearest substitutional Mn acceptors - our calculations evidence that the spins
in such pairs are antiferromagnetically coupled by the superexchange. We also
show that for the Mn ion in the other, hexagonal, interstitial position (which
seems to be the case in the GaMnBeAs samples) the p-d interactions with the
holes, responsible for the ferromagnetism, are very much suppressed.Comment: 4 pages, 3 figures, submitted to PR
Cosmic histories of star formation and reionization: An analysis with a power-law approximation
With a simple power-law approximation of high-redshift () star
formation history, i.e., , we
investigate the reionization of intergalactic medium (IGM) and the consequent
Thomson scattering optical depth for cosmic microwave background (CMB) photons.
A constraint on the evolution index is derived from the CMB optical
depth measured by the {\it Wilkinson Microwave Anisotropy Probe} (WMAP)
experiment, which reads ,
where the free parameter is the number of the escaped
ionizing ultraviolet photons per baryon. Moreover, the redshift for full
reionization, , can also be expressed as a function of as well as
. By further taking into account the implication of the
Gunn-Peterson trough observations to quasars for the full reionization
redshift, i.e., , we obtain
and .
For a typical number of of ionizing photons released per baryon of
normal stars, the fraction of these photons escaping from the stars, , can be constrained to within the range of .Comment: 10 pages, 4 figures, accepted for publication in JCA
Spin Glass Ordering in Diluted Magnetic Semiconductors: a Monte Carlo Study
We study the temperature-dilution phase diagram of a site-diluted Heisenberg
antiferromagnet on a fcc lattice, with and without the Dzyaloshinskii-Moriya
anisotropic term, fixed to realistic microscopic parameters for (IIB=Cd, Hg, Zn). We show that the dipolar Dzyaloshinskii-Moriya anisotropy
induces a finite-temperature phase transition to a spin glass phase, at
dilutions larger than 80%. The resulting probability distribution of the order
parameter P(q) is similar to the one found in the cubic lattice
Edwards-Anderson Ising model. The critical exponents undergo large finite size
corrections, but tend to values similar to the ones of the
Edwards-Anderson-Ising model.Comment: 4 pages plus 3 postscript figure
Role of dipolar and exchange interactions in the positions and widths of EPR transitions for the single-molecule magnets Fe8 and Mn12
We examine quantitatively the temperature dependence of the linewidths and
line shifts in electron paramagnetic resonance experiments on single crystals
of the single-molecule magnets Fe and Mn, at fixed frequency, with
an applied magnetic field along the easy axis. We include inter-molecular
spin-spin interactions (dipolar and exchange) and distributions in both the
uniaxial anisotropy parameter and the Land\'{e} -factor. The temperature
dependence of the linewidths and the line shifts are mainly caused by the
spin-spin interactions. For Fe and Mn, the temperature dependence of
the calculated line shifts and linewidths agrees well with the trends of the
experimental data. The linewidths for Fe reveal a stronger temperature
dependence than those for Mn, because for Mn a much wider
distribution in overshadows the temperature dependence of the spin-spin
interactions. For Fe, the line-shift analysis suggests two competing
interactions: a weak ferromagnetic exchange coupling between neighboring
molecules and a longer-ranged dipolar interaction. This result could have
implications for ordering in Fe at low temperatures.Comment: published versio
Testing a Phenomenologically Extended DGP Model with Upcoming Weak Lensing Surveys
A phenomenological extension of the well-known brane-world cosmology of
Dvali, Gabadadze and Porrati (eDGP) has recently been proposed. In this model,
a cosmological-constant-like term is explicitly present as a non-vanishing
tension sigma on the brane, and an extra parameter alpha tunes the cross-over
scale r_c, the scale at which higher dimensional gravity effects become non
negligible. Since the Hubble parameter in this cosmology reproduces the same
LCDM expansion history, we study how upcoming weak lensing surveys, such as
Euclid and DES (Dark Energy Survey), can confirm or rule out this class of
models. We perform Markov Chain Monte Carlo simulations to determine the
parameters of the model, using Type Ia Supernov\ae, H(z) data, Gamma Ray Bursts
and Baryon Acoustic Oscillations. We also fit the power spectrum of the
temperature anisotropies of the Cosmic Microwave Background to obtain the
correct normalisation for the density perturbation power spectrum. Then, we
compute the matter and the cosmic shear power spectra, both in the linear and
non-linear regimes. The latter is calculated with the two different approaches
of Hu and Sawicki (2007) (HS) and Khoury and Wyman (2009) (KW). With the eDGP
parameters coming from the Markov Chains, KW reproduces the LCDM matter power
spectrum at both linear and non-linear scales and the LCDM and eDGP shear
signals are degenerate. This result does not hold with the HS prescription:
Euclid can distinguish the eDGP model from LCDM because their expected power
spectra roughly differ by the 3sigma uncertainty in the angular scale range
700<l<3000; on the contrary, the two models differ at most by the 1sigma
uncertainty over the range 500<l<3000 in the DES experiment and they are
virtually indistinguishable.Comment: 22 pages, 5 figures, 4 tables, JCAP in pres
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry
Chemotherapeutics tumor resistance is a principal reason for treatment failure, and clinical and experimental data indicate that multidrug transporters such as ATP-binding cassette (ABC) B1 and ABCG2 play a leading role by preventing cytotoxic intracellular drug concentrations. Functional efflux inhibition of existing chemotherapeutics by these pumps continues to present a promising approach for treatment. A contributing factor to the failure of existing inhibitors in clinical applications is limited understanding of specific substrate/inhibitor/pump interactions. We have identified selective efflux inhibitors by profiling multiple ABC transporters against a library of small molecules to find molecular probes to further explore such interactions. In our primary screening protocol using JC-1 as a dual-pump fluorescent reporter substrate, we identified a piperazine-substituted pyrazolo[1,5-a]pyrimidine substructure with promise for selective efflux inhibition. As a result of a focused structure-activity relationship (SAR)-driven chemistry effort, we describe compound 1 (CID44640177), an efflux inhibitor with selectivity toward ABCG2 over ABCB1. Compound 1 is also shown to potentiate the activity of mitoxantrone in vitro as well as preliminarily in vivo in an ABCG2-overexpressing tumor model. At least two analogues significantly reduce tumor size in combination with the chemotherapeutic topotecan. To our knowledge, low nanomolar chemoreversal activity coupled with direct evidence of efflux inhibition for ABCG2 is unprecedented
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