43 research outputs found
Surface properties correlate to the digestibility of hydrothermally pretreated lignocellulosic Poaceae biomass feedstocks
Global matrix 2.0:Report card grades on the physical activity of children and youth comparing 38 countries
Prevalence of suspected developmental delays in early infancy: results from a regional population-based longitudinal study
Living with mentally ill parents during adolescence: a risk factor for future welfare dependence? A longitudinal, population-based study
Background
Living with parents suffering from mental illness can influence adolescentsâ health and well-being, and adverse effects may persist into adulthood. The aim of this study was to investigate the relationship between parentsâ mental health problems reported by their 15â16-year-old adolescents, the potential protective effect of social support and long-term dependence on public welfare assistance in young adulthood.
Methods
The study linked data from a youth health survey conducted during 1999â2004 among approximately 14 000 15â16-year-olds to data from high-quality, compulsory Norwegian registries that followed each participant through February 2010. Cox regression was used to compute hazard ratios for long-term welfare dependence in young adulthood based on several risk factors in 15â16-year-olds, including their parentsâ mental health problems.
Results
Of the total study population, 10% (1397) reported having parents who suffered from some level of mental health problems during the 12Â months prior to the baseline survey; 3% (420) reported that their parents had frequent mental health problems. Adolescent report of their parentsâ mental health problems was associated with the adolescentsâ long-term welfare dependence during follow-up, with hazard ratios (HRs) of 1.49 (CI 1.29â1.71), 1.82 (1.44â2.31) and 2.13 (CI 1.59â2.85) for some trouble, moderate trouble and frequent trouble, respectively, compared with report of no trouble with mental health problems. The associations remained significant after adjusting for socio-demographic factors, although additionally correcting for the adolescentsâ own health status accounted for most of the effect. Perceived support from family, friends, classmates and teachers was analysed separately and each was associated with a lower risk of later welfare dependence. Family and classmate support remained a protective factor for welfare dependence after correcting for all study covariates (HR 0.84, CI 0.78â0.90 and 0.80, 0.75â0.85). We did not find evidence supporting a hypothesized buffering effect of social support.
Conclusions
Exposure to a parentâs mental health problem during adolescence may represent a risk for future welfare dependence in young adulthood. Perceived social support, from family and classmates in particular, may be a protective factor against future long-term welfare dependence
Musculoskeletal extremity pain in Danish school children â how often and for how long? The CHAMPS study-DK
Abstract
Background
Musculoskeletal pain is common in childhood and adolescence, and may be long-lasting and recurrent. Musculoskeletal problems tend to follow adolescents into adulthood, and therefore it is important to design better prevention strategies and early effective treatment. To this end, we need in-depth knowledge about the epidemiology of musculoskeletal extremity problems in this age group, and therefore, the aim of this study was to determine the prevalence, frequency and course of musculoskeletal pain in the upper and lower extremities in a cohort of Danish school children aged 8â14Â years at baseline.
Methods
This was a prospective 3-year school-based cohort study, with information about musculoskeletal pain collected in two ways. Parents answered weekly mobile phone text messages about the presence or absence of musculoskeletal pain in their children, and a clinical consultation was performed in a subset of the children.
Results
We found that approximately half the children had lower extremity pain every study year. This pain lasted on average for 8Â weeks out of a study year, and the children had on average two and a half episodes per study year. Approximately one quarter of the children had upper extremity pain every study year that lasted on average 3Â weeks during a study year, with one and a half episodes being the average. In general, there were more non-traumatic pain episodes compared with traumatic episodes in the lower extremities, whereas the opposite was true in the upper extremities. The most common anatomical pain sites were âkneeâ and âankle/ftâ.
Conclusion
Lower extremity pain among children and adolescents is common, recurrent and most often of non-traumatic origin. Upper extremity pain is less common, with fewer and shorter episodes, and usually with a traumatic onset. Girls more frequently reported upper extremity pain, whereas there was no sex-related difference in the lower extremities. The most frequently reported locations were âkneeâ and âankle/ftâ
Immunomodulating potential of supplementation with probiotics: a doseâÂÂresponse study in healthy young adults
Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations
Nanodiscs are membrane mimetics that consist of a protein belt surrounding a lipid bilayer, and are broadly used for characterization of membrane proteins. Here, we investigate the structure, dynamics and biophysical properties of two small nanodiscs, MSP1D1ÎH5 and ÎH4H5. We combine our SAXS and SANS experiments with molecular dynamics simulations and previously obtained NMR and EPR data to derive and validate a conformational ensemble that represents the structure and dynamics of the nanodisc. We find that it displays conformational heterogeneity with various elliptical shapes, and with substantial differences in lipid ordering in the centre and rim of the discs. Together, our results reconcile previous apparently conflicting observations about the shape of nanodiscs, and pave the way for future integrative studies of larger complex systems such as membrane proteins embedded in nanodiscs
Working with patients suffering from chronic diseases can be a balancing act for health care professionals - a meta-synthesis of qualitative studies
Background
The number of patients with long-term chronic diseases is increasing. These patients place a strain on health care systems and health care professionals (HCPs). Presently, we aimed to systematically review the literature on HCPsâ experiences working with patients with long-term chronic diseases such as type 2 diabetes, chronic obstructive pulmonary disease (COPD), and chronic kidney disease (CKD).
Method
A systematic search of papers published between 2002 and July 2019 was conducted in the Embase, AMED, PsycINFO, MEDLINE, CINAHL, and COCHRANE databases to identify studies reporting qualitative interviews addressing HCPsâ experiences working with adults with COPD, CKD or type 2 diabetes. An interdisciplinary research group were involved in all phases of the study. With the help of NVivo, extracts of each paper were coded, and codes were compared across papers and refined using translational analysis. Further codes were clustered in categories that in turn formed overarching themes.
Results
Our comprehensive search identified 4170 citations. Of these, 20 papers met our inclusion criteria. Regarding HCPsâ experiences working with patients with COPD, CKD, or type 2 diabetes, we developed 10 sub-categories that formed three overarching main themes of work experiences: 1) individualizing oneâs professional approach within the clinical encounter; 2) managing oneâs emotions over time; 3) working to maintain professionalism. Overall these three themes suggest that HCPsâ work is a complex balancing act depending on the interaction between patient and professional, reality and professional ideals, and contextual support and managing oneâs own emotions.
Conclusion
Few qualitative studies highlighted HCPsâ general working experiences, as they mainly focused on the patientsâ experiences or HCPsâ experiences of using particular clinical procedures. This study brings new insights about the complexity embedded in HCPsâ work in terms of weighing different, often contrasting aspects, in order to deliver appropriate practice. Acknowledging, discussing and supporting this complexity can empower HCPs to avoid burning out. Leaders, health organizations, and educational institutions have a particular responsibility to provide HCPs with thorough professional knowledge and systematic support.
Trial registration
PROSPERO number: CRD42019119052