Area-under-the-curve of the receiver operating characteristic for the 13-SNP genetic risk score and by gene locus.

<p>Observed AUC was 0.820 and the locus-specific AUCs were 0.513, 0.524, 0.536, 0.547, 0.555, 0.571, 0.686 and 0.710 from bottom to top.</p

Model fit and discriminative accuracy of parsimonious models.

1<p>SNPs from one additional locus at a time were omitted from the 13-SNP model by starting with the locus with the smallest risk.</p>2<p>Numbering corresponds to IDs in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037979#pone-0037979-t002" target="_blank">Table 2</a>.</p>3<p>This model contained the least number of SNPs without compromising R² or AUC values.</p

Five genetic risk groups and relative risk of AMD (ORs and 95% confidence intervals).

1<p>Fraction of individuals in 1000 Genome Project European Ancestry Samples residing in risk groups.</p

Absolute risks for AMD by modeling a general population for various prevalences of AMD (reflecting various age-groups).

1<p>Approximate age-groups corresponding to the modeled prevalences for 65 and 79 years <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037979#pone.0037979-Augood1" target="_blank">[30]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037979#pone.0037979-Friedman1" target="_blank">[31]</a> and for those above 80 years <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037979#pone.0037979-Jonasson1" target="_blank">[32]</a>.</p>2<p>see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037979#pone-0037979-t004" target="_blank">Table 4</a>.</p

Risk estimates for each of thirteen AMD risk variants from eight gene loci.

<p>Odds ratios (OR) per risk allele were derived from multiple logistic regression models. Horizontal lines indicate 95% confidence intervals.</p