179 research outputs found
A recursive kinematic random forest and alpha beta filter classifier for 2D radar tracks
In this work, we show that by using a recursive random forest together with an alpha beta filter classifier it is possible to classify radar tracks from the tracksâ kinematic data. The kinematic data is from a 2D scanning radar without Doppler or height information. We use random forest as this classifier implicit handles the uncertainty in the position measurements. As stationary targets can have an apparently high speed because of the measurement uncertainty, we use an alpha beta filter classifier to classify stationary targets from moving targets. We show an overall classification rate from simulated data at 82.6 % and from real world data 79.7 %. Additional to the confusion matrix we also show recordings of real world data
Identification of swine influenza virus epitopes and analysis of multiple specificities expressed by cytotoxic T cell subsets
BACKGROUND: Major histocompatibility complex (MHC) class I peptide binding and presentation are essential for antigen-specific activation of cytotoxic T lymphocytes (CTLs) and swine MHC class I molecules, also termed swine leukocyte antigens (SLA), thus play a crucial role in the process that leads to elimination of viruses such as swine influenza virus (SwIV). This study describes the identification of SLA-presented peptide epitopes that are targets for a swine CTL response, and further analyses multiple specificities expressed by SwIV activated CTL subsets. FINDINGS: Four SwIV derived peptides were identified as T cell epitopes using fluorescent influenza:SLA tetramers. In addition, multiple CTL specificities were analyzed using peptide sequence substitutions in two of the four epitope candidates analyzed. Interestingly both conserved and substituted peptides were found to stain the CD4(-)CD8(+) T cell subsets indicating multiple specificities. CONCLUSIONS: This study describes a timely and cost-effective approach for viral epitope identification in livestock animals. Analysis of T cell subsets showed multiple specificities suggesting SLA-bound epitope recognition of different conformations
Work exposure and associated risk of hospitalisation with pneumonia and influenza:A nationwide study
Ischemic Stroke Severity and Mortality in Patients With and Without Atrial Fibrillation
Background Our objective was to investigate stroke severity and subsequent rate of mortality among patients with and without atrial fibrillation (AF). Contemporary data on stroke severity and prognosis in patients with AF are lacking. Methods and Results Firstâtime ischemic stroke patients from the Danish Stroke Registry (January 2005âDecember 2016) were included in an observational study. Patients with AF were matched 1:1 by sex, age, calendar year, and CHA2DS2âVASc score with patients without AF. Stroke severity was determined by the Scandinavian Stroke Scale (0â58 points). The rate of death was estimated by KaplanâMeier plots and multivariable Cox regression. Among 86Â 458 identified patients with stroke, 17Â 205 had AF. After matching, 14Â 662 patients with AF and 14Â 662 patients without AF were included (51.8% women; median age, 79.6Â years [25thâ75th percentile, 71.8â86.0]). More patients with AF had very severe stroke (0â14 points) than patients without AF (13.7% versus 7.9%, P<0.01). The absolute rates of 30âday and 1âyear mortality were significantly higher for patients with AF (12.1% and 28.4%, respectively) versus patients without AF (8.7% and 21.8%, respectively). This held true in adjusted models for 30âday mortality (hazard ratio [HR], 1.40 [95% CI, 1.30â1.51]). However, this association became nonsignificant when additionally adjusting for stroke severity (HR, 1.10 [95% CI, 1.00â1.23]). AF was associated with a higher rate of 1âyear mortality (HR, 1.39 [95% CI, 1.32â1.46]), although it was mediated by stroke severity (HR, 1.15 [95% CI, 1.09â1.23], model including stroke severity). Conclusions In a contemporary nationwide cohort of patients with ischemic stroke, patients with AF had more severe strokes and higher mortality than patients without AF. The difference in mortality was mainly driven by stroke severity
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