Additional file 1 of Metabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers

Additional file 1. Supplementary Fig. S1. Early TNBC cell lines exhibit different basal metabolic activities. Supplementary Fig. S2. Long-term exposure with paclitaxel induces an increase of glycolytic activity in early TNBC cells. Supplementary Fig. S3. Mitochondrial oxidative metabolism is decreased in TNBC cells upon treatment with chemotherapy. Supplementary Fig. S4. Basal glycolytic activity and mitochondrial respiration are heterogeneous in patient-derived TNBC organoid models. Supplementary Fig. S5. Paclitaxel treatment decreases oxidative metabolism in patient-derived TNBC organoids. Supplementary Fig. S6. Increased glycolysis correlates with NAC resistance in patient-derived TNBC clinical specimens. Supplementary Fig. S7. Uncropped images of Western blots. Supplementary Table S1. BC organoid culture medium