3,407 research outputs found
Standard spacecraft economic analysis. Volume 1: Executive summary
A study of the comparative program costs associated with use of various standardized spacecraft for Air Force space test program missions to be flown on the space shuttle during the 1980-1990 time period is reviewed. The first phase of the study considered a variety of procurement mixes composed of existing or programmed NASA standard spacecraft designs and a Air Force standard spacecraft design. The results were briefed to a joint NASA/Air Force audience on July 11, 1976. The second phase considered additional procurement options using an upgraded version of an existing NASA design. The results of both phases are summarized
Standard spacecraft economic analysis. Volume 2: Findings and conclusions
The comparative program costs associated with use of various standardized spacecraft for Air Force space test program missions to be flown on the space shuttle were studied in two phases. In the first phase, a variety of procurement mixes composed of existing or programmed NASA standard spacecraft designs and an Air Force standard spacecraft design were considered. The second phase dealt with additional procurement options using an upgraded version of an existing NASA design. The results of both phases are discussed
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Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle.
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the development of vascular diseases. It is therefore important that we understand the biophysical, molecular composition, activation pathways, and physiological significance of SOCs in VSMCs as these maybe future therapeutic targets for conditions such as hypertension and atherosclerosis. Archetypal SOCs called calcium release-activated channels (CRACs) are composed of Orai1 proteins and are stimulated by the endo/sarcoplasmic reticulum Ca2+ sensor stromal interaction molecule 1 (STIM1) following store depletion. In contrast, this review focuses on proposals that canonical transient receptor potential (TRPC) channels composed of a heteromeric TRPC1/C5 molecular template, with TRPC1 conferring activation by store depletion, mediate SOCs in native contractile VSMCs. In particular, it summarizes our recent findings which describe a novel activation pathway of these TRPC1-based SOCs, in which protein kinase C (PKC)-dependent TRPC1 phosphorylation and phosphatidylinositol 4,5-bisphosphate (PIP2) are obligatory for channel opening. This PKC- and PIP2-mediated gating mechanism is regulated by the PIP2-binding protein myristoylated alanine-rich C kinase (MARCKS) and is coupled to store depletion by TRPC1-STIM1 interactions which induce Gq/PLCβ1 activity. Interestingly, the biophysical properties and activation mechanisms of TRPC1-based SOCs in native contractile VSMCs are unlikely to involve Orai1
Oxidative stress via hydrogen peroxide and menadione does not induce the secretion of IGFBP-5 in primary rat hepatocytes
Conference abstract describing how oxidative stress via hydrogen peroxide and menadione does not induce the secretion of IGFBP-5 in primary rat hepatocytes. Presented at the 2010 annual congress of the british toxicology societ
SUMSS: A Wide-Field Radio Imaging Survey of the Southern Sky. I. Science goals, survey design and instrumentation
The Molonglo Observatory Synthesis Telescope, operating at 843 MHz with a 5
square degree field of view, is carrying out a radio imaging survey of the sky
south of declination -30 deg. This survey (the Sydney University Molonglo Sky
Survey, or SUMSS) produces images with a resolution of 43" x 43" cosec(Dec.)
and an rms noise level of about 1 mJy/beam. SUMSS is therefore similar in
sensitivity and resolution to the northern NRAO VLA Sky Survey (NVSS; Condon et
al. 1998). The survey is progressing at a rate of about 1000 square degrees per
year, yielding individual and statistical data for many thousands of weak radio
sources. This paper describes the main characteristics of the survey, and
presents sample images from the first year of observation.Comment: 27 pages, 12 figures (figures 2, 8, 10 in jpg format); AJ, in pres
Insulin-like growth factor binding protein-5 as a biomarker for detection of early liver disease
Study identifying an Insulin-like growth factor binding protein-5 as a biomarker for detection of early liver disease presented at the annual congress of the british toxicology societ
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