The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance

The multiprotein complexes that receive and transmit axon pathfinding cues during development are essential to circuit generation. Here, we identify and characterize the Drosophila sterile α-motif (SAM) domain-containing protein Caskin, which shares homology with vertebrate Caskin, a CASK [calcium/calmodulin-(CaM)-activated serine-threonine kinase]-interacting protein. Drosophila caskin (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically with the leukocyte common antigen-related (Lar) receptor protein tyrosine phosphatase. In vivo and in vitro analyses of a panel of ckn loss-of-function alleles indicate that the N-terminal SAM domain of Ckn mediates its interaction with Lar. Like Caskin, Liprin-α is a neuronal adaptor protein that interacts with Lar via a SAM domain-mediated interaction. We present evidence that Lar does not bind Caskin and Liprin-α concurrently, suggesting they may assemble functionally distinct signaling complexes on Lar. Furthermore, a vertebrate Caskin homolog interacts with LAR family members, arguing that the role of ckn in Lar signal transduction is evolutionarily conserved. Last, we characterize several ckn mutants that retain Lar binding yet display guidance defects, implying the existence of additional Ckn binding partners. Indeed, we identify the SH2/SH3 adaptor protein Dock as a second Caskin-binding protein and find that Caskin binds Lar and Dock through distinct domains. Furthermore, whereas ckn has a nonredundant function in Lar-dependent signaling during motor axon targeting, ckn and dock have overlapping roles in axon outgrowth in the CNS. Together, these studies identify caskin as a neuronal adaptor protein required for axon growth and guidance

The Yale Lar TPC

In this paper we give a concise description of a liquid argon time projection chamber (LAr TPC) developed at Yale, and present results from its first calibration run with cosmic rays.Comment: 4 pages, 3 figures, NuInt07 Conference Proceeding

Measurement of the two-photon absorption cross-section of liquid argon with a time projection chamber

This paper reports on laser-induced multiphoton ionization at 266 nm of liquid argon in a time projection chamber (LAr TPC) detector. The electron signal produced by the laser beam is a formidable tool for the calibration and monitoring of next-generation large-mass LAr TPCs. The detector that we designed and tested allowed us to measure the two-photon absorption cross-section of LAr with unprecedented accuracy and precision: sigma_ex=(1.24\pm 0.10stat \pm 0.30syst) 10^{-56} cm^4s{-1}.Comment: 15 pages, 9 figure

Preliminary test results of LAr prototype detector

WIMPs are a well-motivated galactic dark matter candidate. Liquid argon (LAr) is an attractive target for the direct detection of WIMPs. The LAr prototype detector is designed to study the technology and property of LAr detector. The prototype detector have an active volume containing 0.65 kg of liquid argon. The liquid nitrogen(LN) cooling system allows the temperature of liquid argon to be maintained at the boiling point (87.8 K) with fluctuations less than 0.1 K. The prototype was calibrated with a Na$^{22}$ source, with the light yield 1.591$\pm$0.019 p.e./keV for the 511 keV gamma rays using the domestic-made argon purification system.Comment: 4 pages, 5 figure

Test of a Liquid Argon TPC in a magnetic field and investigation of high temperature superconductors in liquid argon and nitrogen

Tests with cosmic ray muons of a small liquid argon time projection chamber (LAr TPC) in a magnetic field of 0.55 T are described. No effect of the magnetic field on the imaging properties were observed. In view of a future large, magnetized LAr TPC, we investigated the possibility to operate a high temperature superconducting (HTS) solenoid directly in the LAr of the detector. The critical current $I_c$ of HTS cables in an external magnetic field was measured at liquid nitrogen and liquid argon temperatures and a small prototype HTS solenoid was built and tested.Comment: 5 pages, 5 figures, to appear in Proc. of 1st International Workshop towards the Giant Liquid Argon Charge Imaging Experiment (GLA2010), Tsukuba (Japan), March 201

ANALYSING THE HOUSING MARKET STRUCTURE IN ROMANIA AND TURKEY UNDER THE GLOBAL FINANCIAL CRISIS EFFECT

Housing is the most important asset in the portfolio of most households. For allhouseholds it is an important determinant of quality of life. It is a relatively illiquid investment, withan uncertain capital value, and it is generally highly leveraged, which makes it a potentially importantchannel of transmission of monetary policy. On the other hand, housing finance is a crucialimportance to the macro-economic system as mortgage loans account for a large proportion ofbank lending. Indicators related to mortgage market activities and banks’ exposures to real estatelending are also useful indicators for monitoring the health of the banking sector. This article aimsto present a comparative analysis of the housing market structure in Romania and Turkey beforeand after the global financial crisis.Housing Market, Mortgage Loans, Bank Lending, Financial Crisis, Romania, Turkey