1,078 research outputs found
Universal Scaling of Wave Propagation Failure in Arrays of Coupled Nonlinear Cells
We study the onset of the propagation failure of wave fronts in systems of
coupled cells. We introduce a new method to analyze the scaling of the critical
external field at which fronts cease to propagate, as a function of
intercellular coupling. We find the universal scaling of the field throughout
the range of couplings, and show that the field becomes exponentially small for
large couplings. Our method is generic and applicable to a wide class of
cellular dynamics in chemical, biological, and engineering systems. We confirm
our results by direct numerical simulations.Comment: 4 pages, 3 figures, RevTe
Avalanche of Bifurcations and Hysteresis in a Model of Cellular Differentiation
Cellular differentiation in a developping organism is studied via a discrete
bistable reaction-diffusion model. A system of undifferentiated cells is
allowed to receive an inductive signal emenating from its environment.
Depending on the form of the nonlinear reaction kinetics, this signal can
trigger a series of bifurcations in the system. Differentiation starts at the
surface where the signal is received, and cells change type up to a given
distance, or under other conditions, the differentiation process propagates
through the whole domain. When the signal diminishes hysteresis is observed
New Developments in Quantum Algorithms
In this survey, we describe two recent developments in quantum algorithms.
The first new development is a quantum algorithm for evaluating a Boolean
formula consisting of AND and OR gates of size N in time O(\sqrt{N}). This
provides quantum speedups for any problem that can be expressed via Boolean
formulas. This result can be also extended to span problems, a generalization
of Boolean formulas. This provides an optimal quantum algorithm for any Boolean
function in the black-box query model.
The second new development is a quantum algorithm for solving systems of
linear equations. In contrast with traditional algorithms that run in time
O(N^{2.37...}) where N is the size of the system, the quantum algorithm runs in
time O(\log^c N). It outputs a quantum state describing the solution of the
system.Comment: 11 pages, 1 figure, to appear as an invited survey talk at MFCS'201
Advances in Networking Software
The six articles in this special section focus on advancements in networking software. Networking and communications systems are currently undergoing a substantive transformation on several fronts, promising substantially lower cost, simplified operations, and dramatically faster innovation cycles as traditional barriers to the deployment of innovations are removed. Where in the past networking functions were predominantly implemented using purpose-built hardware, custom protocols, and firmware images, those networking functions are increasingly instantiated through software that is abstracted from hardware, freely programmable, and relying on algorithmic invocation of generic application programming interfaces (APIs). This transformation is best summarized as âsoftwarizationâ of the network, which is, in turn, realized through advances in networking software. These articles exemplify this transformation, providing an excellent cross-section across these facets
Localization of Heat Shock Protein 27 (Hsp27) in the Rat Gingiva and its Changes with Tooth Eruption
Heat shock protein 27 kDa (Hsp27) functions as a molecular chaperon to prevent apoptosis as well as to contribute to the regulation of cell proliferation and differentiation during development. In the present study, the localization of Hsp27 in the oral epithelium of rats and its expression change during formation of the gingiva with the tooth eruption were examined immunohistochemically to elucidate the roles of Hsp27 in the oral mucosa
Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer
Chiral, dimeric natural products containing complex structures and interesting biological properties have inspired chemists and biologists for decades. A seven-step total synthesis of the axially chiral, dimeric tetrahydroxanthone natural product rugulotrosin A is described. The synthesis employs a one-pot Suzuki coupling/dimerization to generate the requisite 2,2'-biaryl linkage. Highly selective point-to-axial chirality transfer was achieved using palladium catalysis with achiral phosphine ligands. Single X-ray crystal diffraction data were obtained to confirm both the atropisomeric configuration and absolute stereochemistry of rugulotrosin A. Computational studies are described to rationalize the atropselectivity observed in the key dimerization step. Comparison of the crude fungal extract with synthetic rugulotrosin A and its atropisomer verified that nature generates a single atropisomer of the natural product.P50 GM067041 - NIGMS NIH HHS; R01 GM099920 - NIGMS NIH HHS; GM-067041 - NIGMS NIH HHS; GM-099920 - NIGMS NIH HH
Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer.
Dysregulation of the PI3K-AKT-mTOR signaling network is a prominent feature of breast cancers. However, clinical responses to drugs targeting this pathway have been modest, possibly because of dynamic changes in cellular signaling that drive resistance and limit drug efficacy. Using a quantitative chemoproteomics approach, we mapped kinome dynamics in response to inhibitors of this pathway and identified signaling changes that correlate with drug sensitivity. Maintenance of AURKA after drug treatment was associated with resistance in breast cancer models. Incomplete inhibition of AURKA was a common source of therapy failure, and combinations of PI3K, AKT or mTOR inhibitors with the AURKA inhibitor MLN8237 were highly synergistic and durably suppressed mTOR signaling, resulting in apoptosis and tumor regression in vivo. This signaling map identifies survival factors whose presence limits the efficacy of targeted therapies and reveals new drug combinations that may unlock the full potential of PI3K-AKT-mTOR pathway inhibitors in breast cancer
The Hilbertian Tensor Norm and Entangled Two-Prover Games
We study tensor norms over Banach spaces and their relations to quantum
information theory, in particular their connection with two-prover games. We
consider a version of the Hilbertian tensor norm and its dual
that allow us to consider games with arbitrary output alphabet
sizes. We establish direct-product theorems and prove a generalized
Grothendieck inequality for these tensor norms. Furthermore, we investigate the
connection between the Hilbertian tensor norm and the set of quantum
probability distributions, and show two applications to quantum information
theory: firstly, we give an alternative proof of the perfect parallel
repetition theorem for entangled XOR games; and secondly, we prove a new upper
bound on the ratio between the entangled and the classical value of two-prover
games.Comment: 33 pages, some of the results have been obtained independently in
arXiv:1007.3043v2, v2: an error in Theorem 4 has been corrected; Section 6
rewritten, v3: completely rewritten in order to improve readability; title
changed; references added; published versio
Dementia and detectives: Alzheimer's disease in crime fiction
Fictional representations of dementia have burgeoned in recent years, and scholars have amply explored their double-edged capacity to promote tragic perspectives or normalising images of âliving wellâ with the condition. Yet to date, there has been only sparse consideration of the treatment afforded dementia within the genre of crime fiction. Focusing on two novels, Emma Healeyâs Elizabeth is Missing and Alice LaPlanteâs Turn of Mind, this article considers what it means in relation to the ethics of representation that these authors choose to cast as their amateur detective narrators women who have dementia. Analysing how their narrative portrayals frame the experience of living with dementia, it becomes apparent that features of the crime genre inflect the meanings conveyed. While aspects of the novels may reinforce problem-based discourses around dementia, in other respects they may spur meaningful reflection about it among the large readership of this genre
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