16 research outputs found
Erupción primaveral juvenil
La EPJ fue descrita en el año 1954 por Anderson y colaboradores. Desde entonces, las referencias en la literatura son escasas. Esto podría deberse, en parte, al curso benigno y autolimitado por el que se caracteriza y podría ser más frecuente de lo que ha sido reflejado. Se han descrito brotes epidémicos infantiles o en personal militar.
Desde el punto de vista epidemiológico, afecta, principalmente, a niños o varones jóvenes con orejas prominentes y ausencia de cabello que las cubre, generalmente, al inicio de la primavera, durante días fríos y soleados. De forma más infrecuente, también se han descrito casos en el sexo femenino.
Las lesiones cutáneas aparecen pocas horas tras una exposición solar y se caracterizan por un eritema y edema de fondo, sobre el que aparecen pápulas eritematosas, vesículas y, posteriormente, costras. Su localización principal son los pabellones auriculares, y es rara la afectación en otros niveles. Estas lesiones se curan de forma espontánea y sin dejar cicatriz, y es posible la aparición de nuevos brotes en primaveras sucesivas, aunque, generalmente, de menor intensidad..
Association between adiposity levels and cognitive impairment in the Chilean older adult population
Although both obesity and ageing are risk factors for cognitive impairment, there is no evidence in Chile on how obesity levels are associated with cognitive function. Therefore, the aim of the present study was to investigate the association between adiposity levels and cognitive impairment in older Chilean adults. This cross-sectional study includes 1384 participants, over 60 years of age, from the Chilean National Health Survey 2009–2010. Cognitive impairment was evaluated using the Mini-Mental State Examination. BMI and waist circumference (WC) were used as measures of adiposity. Compared with people with a normal BMI, the odds of cognitive impairment were higher in participants who were underweight (OR 4·44; 95 % CI 2·43, 6·45; P < 0·0001), overweight (OR 1·86; 95 % CI 1·06, 2·66; P = 0·031) and obese (OR 2·26; 95 % CI 1·31, 3·21; P = 0·003). The associations were robust after adjustment for confounding variables. Similar results were observed for WC. Low and high levels of adiposity are associated with an increased likelihood of cognitive impairment in older adults in Chile
Reduced erythrocyte glutathione and urinary thioethers in children treated with paracetamol as antipyretic
Expression of muscarinic acetylcholine receptors (M1-, M2-, M3- and M4-type) in the neuromuscular junction of the newborn and adult rat
Using intracellular recording and
immunohistochemistry, we studied the presynaptic
muscarinic autoreceptor subtypes controlling ACh
release in the neuromuscular junctions of the newborn
(3-6 days postnatal) and adult (30-40 days) rat. In the
Levator auris longus muscles of both newborn and adult
rats, acetylcholine release was modified by the M1-
receptor selective antagonists pirenzepine (10 µM) and
MT-7 (100 nM) and by the M2-receptor selective
antagonists methoctramine (1 µM) and AF-DX 116 (10
µM). The M4-receptor selective antagonists tropicamide
(1 µM) and MT-3 (100 nM) can also modify the
neurotransmitter release in certain synapses of the
newborn muscles. The neurotransmitter release was not
altered by the M3-receptor selective antagonist 4-DAMP
(1 µM) in the adult or newborn rats. However, we
directly demonstrate by immunocytochemistry the
presence of these receptors in the motor endplates and
conclude that M1-, M2-, M3- and M4-type muscarinic
receptors are present in all the neuromuscular junctions
of the rat muscle both in newborn and adult animals.
These receptors may be located in the perisynaptic glial
cell as well as at the nerve terminals
Topological differences along mammalian motor nerve terminals for spontaneous and alpha-Bungarotoxin-induced sprouting
Spontaneous sproutings can be observed in
end plates from normal adult vertebrate muscles and
motor end plates develop increased growth signs and
sprouts when target muscle cells become less active or
paralysed. Nevertheless, very little is known about
where in the motor nerve terminal arborization
spontaneous and experimentally induced sprouts
originate, their similarities and differences and also
about their final maturation or elimination. In this study
we investigate the topological properties of both
spontaneous and alpha-bungarotoxin-induced sprouts
(during different periods of intoxication and after
recovery) along the motor nerve terminal branches of the
Levator auris longus muscle of Swiss mice (between 48-
169 day old).
Muscles were processed for immunocytochemistry
to simultaneously detect postsynaptic AChRs and axons.
This procedurk permits us to make an accurate
identification of the fine sprouts and a morphometric
study of the presynaptic branching pattern profile in
control muscles, during the toxin action and after
recovery from paralysis.
The results show that in normal muscles, the initial
and trunk segments (those between branch points) of the
terminal arborization sprouted proportionally more
branches when taking their relative lengths into account
than the distal free-end segments. In contrast, every micrometer of alpha-bungarotoxin-treated muscles
throughout the full terminal arborization have the same
probability of generating a sprout. Moreover, the toxininduced
sprouts can consolidate as new branches once
recovered from the paralysis without changing the total
length of the nerve terminal arborization
Sister-chromatid exchanges, chromosome aberrations, proliferating rate index and urinary thioethers in patients undergoing long-term therapy with carbamazepine
rhGH therapy in GH-deficient states for one year does not increase the risk of exposure to mutagens
Cellular localization of the atypical isoforms of protein kinase C (aPKCζ/PKMζ and aPKCλ/ι) on the neuromuscular synapse
10.1016/j.neulet.2013.10.00
Adenosine A2B and A3 receptor location at the mouse neuromuscular junction
10.1111/joa.12188To date, four subtypes of adenosine receptors have been cloned (A1R, A2AR, A2BR, and A3R). In a previous study we used confocal immunocytochemistry to identify A1R and A2AR receptors at mouse neuromuscular junctions (NMJs). The data shows that these receptors are localized differently in the three cells (muscle, nerve and glia) that configure the NMJs. A1R localizes in the terminal teloglial Schwann cell and nerve terminal, whereas A2AR localizes in the postsynaptic muscle and in the axon and nerve terminal. Here, we use Western blotting to investigate the presence of A2BR and A3R receptors in striated muscle and immunohistochemistry to localize them in the three cells of the adult neuromuscular synapse. The data show that A2BR and A3R receptors are present in the nerve terminal and muscle cells at the NMJs. Neither A2BR nor A3R receptors are localized in the Schwann cells. Thus, the four subtypes of adenosine receptors are present in the motor endings. The presence of these receptors in the neuromuscular synapse allows the receptors to be involved in the modulation of transmitter release