1 research outputs found
Novel TEMPO-PEG-RGDs Conjugates Remediate Tissue Damage Induced by Acute Limb Ischemia/Reperfusion
We have recently developed new Tempo-PEG-RGDs conjugates
and have quantitatively examined their antithrombotic and antioxidant
capabilities. These compounds were therapeutically beneficial when
characterized in both in vitro platelet aggregation assays and a rat
model of arterial thrombosis. Moreover, these compounds demonstrated
significant protection from organ damage in a rat model of ischemia/reperfusion.
Our data indicate that Tempo-PEG-RGDs represent a new class of adjuvants
with therapeutic efficacy in acute and transient ischemic damage