Limiting the reliance on navigation assistance with navigation instructions containing emotionally salient narratives for confident wayfinding

We live in a world that is increasingly dependent on technology, including for orientation in both familiar and unfamiliar space, which contributes to a long-term erosion of innate spatial navigation skills. In this study, we examined whether modified navigation instructions can make pedestrians less reliant on navigation aids to solve wayfinding tasks. In contrast to standard instructions, the modified instructions make decision-relevant landmarks at intersections emotionally salient and connected through narrative, and thus more memorable. The results of our online VR study with seventy adults revealed that, after navigating an unfamiliar route using modified navigation instructions, people made significantly fewer references to the navigation aid without compromising the accuracy of navigation compared to standard instructions. Narrative-based navigation instructions improved memory for the order in which relevant features in the environment were encountered along the traversed route, but not landmark recognition memory or memory for landmark-direction associations. Our findings highlight the benefits of using human-centred technologies that – as opposed to current navigation systems – promote the encoding and memorability of spatial information during navigation, and have the potential to train human spatial navigation abilities in the long term as a countermeasure toward GPS cognitive deskilling of population

The Effect of Abstract vs. Realistic 3D Visualization on Landmark and Route Knowledge Acquisition

Even though humans perform it daily, navigation is a cognitively challenging process. Landmarks have been shown to facilitate navigation by scaffolding humans’ mental representation of space. However, how landmarks can be effectively communicated to pedestrians to support spatial learning of the traversed environment remains an open question. Therefore, we assessed how the visualization of landmarks on a mobile map (i.e., abstract 3D vs. realistic 3D symbols) influences participants’ spatial learning, visual attention allocation, and cognitive load during an outdoor map-assisted navigation task. We report initial results on how exposing pedestrians to different landmark visualization styles on mobile maps while navigating along a given route in an urban environment can have differing effects on how they remember landmarks and routes. Specifically, we find that navigators better remember landmarks visualized as 3D realistic-looking symbols compared to 3D abstract landmark symbols on the mobile map. The pattern of results shows that displaying realistic 3D landmark symbols at intersections potentially helps participants to remember route directions better than with landmarks depicted as abstract 3D symbols. The presented methodological approach contributes ecologically valid insights to further understand how the design of landmarks on mobile maps could support wayfinders' spatial learning during map-assisted navigation

The positive effect of blue luminescent pathways on urban park visitor’s affective states: A virtual reality online study measuring facial expressions and self-reports

The colour blue often elicits feelings of calmness and contentment, for which evidence has largely been provided in daytime settings. It is unclear whether pathways illuminated in blue, for example, in urban recreational park areas at night confers the same positive impact on night time park visitors. To tackle this open empirical question, we investigated how adding blue self-luminous pavement to park lighting at night time affects park visitors’ emotions compared to conventional white street light illumination. Our goal is to inform design decisions aimed at enhancing the emotional well-being of people outdoors at night in urban environments. Participants’ emotional response was captured at four different time points while watching a video of a walk in a virtual urban park at night, which was lit with white street lights only or with the addition of blue luminescent pavement on the walked paths (between-subject design). To capture visitor’s emotions, we used a simplified version of the Geneva Emotion Wheel (GEW) instrument and online facial expression recognition technology as subjective (self-reports) and objective (physiological) measures of emotion, respectively. The results of the GEW self-reports showed that the addition of a blue self-luminous pavement in a park during night time yielded more positive affect than standard white lighting in park visitors for the first half of the walk. In the second half of the walk through the park, participants’ affective states seemed to equalize between the two lighting conditions. In contrast, sensory data on facial expressions indicated no difference between participants’ emotional states over the whole walk in the two experimental conditions. Consistent with the positive emotional state perceived in the second half of the walk, the state of relaxation experienced after the walk also did not differ between the two lighting conditions. Furthermore, participants’ relaxation judgements after the park walk were more negative overall for females than the more neutral ratings of males. Our results highlight the importance of lighting colour at night for the design of future affect-smart cities that may consider individual and group characteristics with the ultimate intent of promoting public well-being

How does the design of landmarks on a mobile map influence wayfinding experts’ spatial learning during a real-world navigation task?

Humans increasingly rely on GPS-enabled mobile maps to navigate novel environments. However, this reliance can negatively affect spatial learning, which can be detrimental even for expert navigators such as search and rescue personnel. Landmark visualization has been shown to improve spatial learning in general populations by facilitating object identification between the map and the environment. How landmark visualization supports expert users’ spatial learning during map-assisted navigation is still an open research question. We thus conducted a real-world study with wayfinding experts in an unknown residential neighborhood. We aimed to assess how two different landmark visualization styles (abstract 2D vs. realistic 3D buildings) would affect experts’ spatial learning in a map-assisted navigation task during an emergency scenario. Using a between-subjects design, we asked Swiss military personnel to follow a given route using a mobile map, and to identify five task-relevant landmarks along the route. We recorded experts’ gaze behavior while navigating and examined their spatial learning after the navigation task. We found that experts’ spatial learning improved when they focused their visual attention on the environment, but the direction of attention between the map and the environment was not affected by the landmark visualization style. Further, there was no difference in spatial learning between the 2D and 3D groups. Contrary to previous research with general populations, this study suggests that the landmark visualization style does not enhance expert navigators’ navigation or spatial learning abilities, thus highlighting the need for population-specific mobile map design solutions

Immunogenicity and reactogenicity of modified vaccinia Ankara pre-exposure vaccination against mpox according to previous smallpox vaccine exposure and HIV infection. Prospective cohort study

Background: Pre-exposure vaccination with MVA-BN has been widely used against mpox to contain the 2022 outbreak. Many countries have defined prioritized strategies, administering a single dose to those historically vaccinated for smallpox, to achieve quickly adequate coverage in front of low supplies. Using epidemiological models, real-life effectiveness was estimated at approximately 36%-86%, but no clinical trials were performed. Few data on MVA-BN immunogenicity are currently available, and there are no established correlates of protection. Immunological response in PLWH in the context of the 2022 outbreak was also poorly described. Methods: Blood samples were collected from participants eligible for pre-exposure MVA-BN vaccination before (T1) receiving a full course of vaccine (single-dose for vaccine-experienced or smallpox-primed and two-dose for smallpox vaccine-naïve or smallpox non-primed) and one month after the last dose (T2 and T3, respectively). MPXV-specific IgGs were measured by in-house immunofluorescence assay, using 1:20 as screening dilution, MPXV-specific nAbs by 50% plaque reduction neutralization test (PRNT50, starting dilution 1:10), and IFN-γ-producing specific T cells to MVA-BN vaccine, by ELISpot assay. Paired or unpaired t-test and Wilcoxon or Mann-Whitney test were used to analyse IgG and nAbs, and T-cell response, as appropriate. The probability of IgG and nAb response in vaccine-experienced vs. vaccine-naïve was estimated in participants not reactive at T1. The McNemar test was used to evaluate vaccination's effect on humoral response both overall and by smallpox vaccination history. In participants who were not reactive at T1, the proportion of becoming responders one month after full-cycle completion by exposure groups was compared by logistic regression and then analysed by HIV status strata (interaction test). The response was also examined in continuous, and the Average Treatment Effect (ATE) of the difference from baseline to schedule completion according to previous smallpox vaccination was estimated after weighting for HIV using a linear regression model. Self-reports of adverse effects following immunization (AEFIs) were prospectively collected after the first MVA-BN dose (T1). Systemic (S-AEFIs: fatigue, myalgia, headache, GI effects, chills) and local (L-AEFIs: redness, swelling, pain) AEFIs were graded as absent (grade 0), mild (1), moderate (2), or severe (3). The maximum level of severity for S-AEFIs and L-AEFIs ever experienced over the 30 days post-dose by vaccination exposure groups were analysed using a univariable multinomial logistic regression model and after adjusting for HIV status; for each of the symptoms, we also compared the mean duration by exposure group using an unpaired t-test. Findings: Among the 164 participants included, 90 (54.8%) were smallpox vaccine-experienced. Median age was 49 years (IQR 41-55). Among the 76 (46%) PLWH, 76% had a CD4 count >500 cells/μL. There was evidence that both the IgG and nAbs titers increased after administration of the MVA-BN vaccine. However, there was no evidence for a difference in the potential mean change in humoral response from baseline to the completion of a full cycle when comparing primed vs. non-primed participants. Similarly, there was no evidence for a difference in the seroconversion rate after full cycle vaccination in the subset of participants not reactive for nAbs at T1 (p = 1.00 by Fisher's exact test). In this same analysis and for the nAbs outcome, there was some evidence of negative effect modification by HIV (interaction p-value = 0.17) as primed people living with HIV (PLWH) showed a lower probability of seroconversion vs. non-primed, and the opposite was seen in PLWoH. When evaluating the response in continuous, we observed an increase in T-cell response after MVA-BN vaccination in both primed and non-primed. There was evidence for a larger increase when using the 2-dose vs. one-dose strategy with a mean difference of -2.01 log2 (p ≤ 0.0001), after controlling for HIV. No evidence for a difference in the risk of developing any AEFIs of any grade were observed by exposure group, except for the lower risk of grade 2 (moderate) fatigue, induration and local pain which was lower in primed vs. non-primed [OR 0.26 (0.08-0.92), p = 0.037; OR 0.30 (0.10-0.88), p = 0.029 and OR 0.19 (0.05-0.73), p = 0.015, respectively]. No evidence for a difference in symptom duration was also detected between the groups. Interpretation: The evaluation of the humoral and cellular response one month after the completion of the vaccination cycle suggested that MVA-BN is immunogenic and that the administration of a two-dose schedule is preferable regardless of the previous smallpox vaccination history, especially in PLWH, to maximize nAbs response. MVA-BN was safe as well tolerated, with grade 2 reactogenicity higher after the first administration in vaccine-naïve than in vaccine-experienced individuals, but with no evidence for a difference in the duration of these adverse effects. Further studies are needed to evaluate the long-term duration of immunity and to establish specific correlates of protection. Funding: The study was supported by the National Institute for Infectious Disease Lazzaro Spallanzani IRCCS "Advanced grant 5 × 1000, 2021" and by the Italian Ministry of Health "Ricerca Corrente Linea 2"

Immunogenicity and reactogenicity of modified vaccinia Ankara pre-exposure vaccination against mpox according to previous smallpox vaccine exposure and HIV infection: prospective cohort study

BACKGROUND: Pre-exposure vaccination with MVA-BN has been widely used against mpox to contain the 2022 outbreak. Many countries have defined prioritized strategies, administering a single dose to those historically vaccinated for smallpox, to achieve quickly adequate coverage in front of low supplies. Using epidemiological models, real-life effectiveness was estimated at approximately 36%–86%, but no clinical trials were performed. Few data on MVA-BN immunogenicity are currently available, and there are no established correlates of protection. Immunological response in PLWH in the context of the 2022 outbreak was also poorly described. METHODS: Blood samples were collected from participants eligible for pre-exposure MVA-BN vaccination before (T1) receiving a full course of vaccine (single-dose for vaccine-experienced or smallpox-primed and two-dose for smallpox vaccine-naïve or smallpox non-primed) and one month after the last dose (T2 and T3, respectively). MPXV-specific IgGs were measured by in-house immunofluorescence assay, using 1:20 as screening dilution, MPXV-specific nAbs by 50% plaque reduction neutralization test (PRNT50, starting dilution 1:10), and IFN-γ-producing specific T cells to MVA-BN vaccine, by ELISpot assay. Paired or unpaired t-test and Wilcoxon or Mann–Whitney test were used to analyse IgG and nAbs, and T-cell response, as appropriate. The probability of IgG and nAb response in vaccine-experienced vs. vaccine-naïve was estimated in participants not reactive at T1. The McNemar test was used to evaluate vaccination's effect on humoral response both overall and by smallpox vaccination history. In participants who were not reactive at T1, the proportion of becoming responders one month after full-cycle completion by exposure groups was compared by logistic regression and then analysed by HIV status strata (interaction test). The response was also examined in continuous, and the Average Treatment Effect (ATE) of the difference from baseline to schedule completion according to previous smallpox vaccination was estimated after weighting for HIV using a linear regression model. Self-reports of adverse effects following immunization (AEFIs) were prospectively collected after the first MVA-BN dose (T1). Systemic (S-AEFIs: fatigue, myalgia, headache, GI effects, chills) and local (L-AEFIs: redness, swelling, pain) AEFIs were graded as absent (grade 0), mild (1), moderate (2), or severe (3). The maximum level of severity for S-AEFIs and L-AEFIs ever experienced over the 30 days post-dose by vaccination exposure groups were analysed using a univariable multinomial logistic regression model and after adjusting for HIV status; for each of the symptoms, we also compared the mean duration by exposure group using an unpaired t-test. FINDING: Among the 164 participants included, 90 (54.8%) were smallpox vaccine-experienced. Median age was 49 years (IQR 41–55). Among the 76 (46%) PLWH, 76% had a CD4 count >500 cells/μL. There was evidence that both the IgG and nAbs titers increased after administration of the MVA-BN vaccine. However, there was no evidence for a difference in the potential mean change in humoral response from baseline to the completion of a full cycle when comparing primed vs. non-primed participants. Similarly, there was no evidence for a difference in the seroconversion rate after full cycle vaccination in the subset of participants not reactive for nAbs at T1 (p = 1.00 by Fisher's exact test). In this same analysis and for the nAbs outcome, there was some evidence of negative effect modification by HIV (interaction p-value = 0.17) as primed people living with HIV (PLWH) showed a lower probability of seroconversion vs. non-primed, and the opposite was seen in PLWoH. When evaluating the response in continuous, we observed an increase in T-cell response after MVA-BN vaccination in both primed and non-primed. There was evidence for a larger increase when using the 2-dose vs. one-dose strategy with a mean difference of −2.01 log2 (p ≤ 0.0001), after controlling for HIV. No evidence for a difference in the risk of developing any AEFIs of any grade were observed by exposure group, except for the lower risk of grade 2 (moderate) fatigue, induration and local pain which was lower in primed vs. non-primed [OR 0.26 (0.08–0.92), p = 0.037; OR 0.30 (0.10–0.88), p = 0.029 and OR 0.19 (0.05–0.73), p = 0.015, respectively]. No evidence for a difference in symptom duration was also detected between the groups. INTERPRETATION: The evaluation of the humoral and cellular response one month after the completion of the vaccination cycle suggested that MVA-BN is immunogenic and that the administration of a two-dose schedule is preferable regardless of the previous smallpox vaccination history, especially in PLWH, to maximize nAbs response. MVA-BN was safe as well tolerated, with grade 2 reactogenicity higher after the first administration in vaccine-naïve than in vaccine-experienced individuals, but with no evidence for a difference in the duration of these adverse effects. Further studies are needed to evaluate the long-term duration of immunity and to establish specific correlates of protection

The impact of landmark visualization style on expert wayfinders’ cognitive load during navigation

Our daily navigation and wayfinding activities are cognitively challenging processes, especially in unfamiliar environments (Farr et al., 2012). Landmarks have proven to facilitate navigation (Couclelis et al., 1987). Despite the acknowledged importance of landmarks for human navigation, it is still undecided how we should display them in a perceptually salient and cognitively supportive way on mobile maps. We aim to identify landmark designs that help redirect participants’ gaze to the traversed environment to support participants’ spatial knowledge acquisition during navigation, while also reducing participants’ cognitive load. Landmark designs at various levels of abstraction, including 2D and 3D depictions have been proposed (Döllner, 2007; Elias & Paelke, 2008). Elias and Paelke (2008) suggest a landmark abstraction continuum for point features, ranging from 3D photorealistic (images) to 2D abstract (labels) on maps. Others have suggested fully photorealistic navigation displays in 3D (Nurminen & Oulasvirta, 2008) because these seem to facilitate landmark recognition on the navigation system display, thus making the design superior to abstract 2D maps for novice users (Plesa & Cartwright, 2008). One drawback of realistic 3D depictions is the amount of information presented to users, potentially leading to greater cognitive load and mental efforts because of the increased visual density (Liao et al., 2017). To mitigate this, Liao et al., 2017 suggest combining 2D and 3D, where only landmarks are depicted as photorealistic 3D features on the 2D mobile map. We report on preliminary empirical results from an outdoor navigation study with expert map users and wayfinders, designed to assess how abstract 2D and more realistic 3D landmark depictions (between-subject) might influence participants’ cognitive load during wayfinding in an unfamiliar environment. Based on previous inconclusive research, we formulated two competing hypotheses for this study: (1) participants’ cognitive load will be higher with the more realistic 3D landmarks due to the greater amount of visual information that needs to be processed, and (2), participants’ cognitive load will be lower for task-relevant 3D landmarks because their identification in the traversed environment will be facilitated by this visualization style

The influence of landmark visualization style on expert wayfinders' visual attention during a real-world navigation task

Landmarks serve to structure the environment we experience, and therefore they are also critically important for our everyday movement through and knowledge acquisition about space. How to effectively visualize landmarks to support spatial learning during map-assisted pedestrian navigation is still an open question. We thus set out to assess how landmark visualization styles (i.e., abstract 2D vs. realistic 3D) influence map-assisted spatial learning of expert wayfinders in an outdoor navigation study. Below we report on how the visualization of landmarks on mobile maps might influence wayfinder’s gaze behavior while trying to find a set of landmarks along a given route in an unfamiliar environment. We find that navigators assisted with mobile maps showing realistic-looking 3D landmarks more equally share their visual attention on task-relevant information, while those assisted with maps containing abstract 2D landmarks frequently switch their visual attention between the visualized landmarks and the mobile map to complete the navigation task. The presented analysis approach for the assessment of wayfinder’s gaze patterns has the potential to contribute ecologically valid insights for the understanding of human visual attention allocation during outdoor navigation, and to further understand how landmark depiction styles on mobile maps might guide wayfinders’ visual attention back to the environment to support spatial learning during map-assisted navigation