Learning an atlas of a cognitive process in its functional geometry

Proceedings of the 22nd International Conference, IPMI 2011, Kloster Irsee, Germany, July 3-8, 2011.In this paper we construct an atlas that captures functional characteristics of a cognitive process from a population of individuals. The functional connectivity is encoded in a low-dimensional embedding space derived from a diffusion process on a graph that represents correlations of fMRI time courses. The atlas is represented by a common prior distribution for the embedded fMRI signals of all subjects. The atlas is not directly coupled to the anatomical space, and can represent functional networks that are variable in their spatial distribution. We derive an algorithm for fitting this generative model to the observed data in a population. Our results in a language fMRI study demonstrate that the method identifies coherent and functionally equivalent regions across subjects.National Science Foundation (U.S.) (IIS/CRCNS 0904625)National Science Foundation (U.S.) (CAREER grant 0642971)National Institutes of Health (U.S.) (NCRR NAC P41- RR13218)National Institute of Biomedical Imaging and Bioengineering (U.S.) (U54-EB005149)National Institutes of Health (U.S.) (U41RR019703)National Institutes of Health (U.S.) (P01CA067165)Seventh Framework Programme (European Commission) (n◦257528 (KHRESMOI)

Conformation of 1,4-dihydropyridine — planar or boat-like?

AbstractThe geometry of the 1,4-dihydropyridine molecule was completely optimized employing three different ab initio basis sets (6–31 G*, 4–31 G, STO—3G). The most reliable 6–31G* basis set provides a very flat boat conformation which may easily undergo defolding to a planar ring arrangement. This result is discussed with respect to enzymatic redox cofactors and the pharmacological activity of dihydropyridine calcium antagonists

Measurement of the Ds Lifetime

We report the results of a precise measurement of the Ds meson lifetime based on 1662 +/- 56 fully reconstructed Ds -> phi pi decays, from the charm hadroproduction experiment E791 at Fermilab. Using an unbinned maximum likelihood fit, we measure the Ds lifetime to be 0.518 +/- 0.014 +/- 0.007 ps. The ratio of the measured Ds lifetime to the world average D0 lifetime is 1.25 +/- 0.04. This result differs from unity by six standard deviations, indicating significantly different lifetimes for the Ds and the D0.Comment: 12 pages, 3 figures, 2 table. LaTe

Search for the Flavor-Changing Neutral-Current Decays D+→π+μ+μ−D^+\to \pi^+ \mu^+ \mu^- and D+→π+e+e−D^+\to \pi^+ e^+ e^-

We report the results of a search for the flavor-changing neutral-current decays $D^+\rightarrow \pi^+ \mu^+ \mu^-$ and $D^+\rightarrow \pi^+ e^+ e^-$ in data from Fermilab charm hadroproduction experiment E791. No signal above background is found, and we obtain upper limits on branching fractions, $B(D^+\rightarrow \pi^+ \mu^+ \mu^-) < 1.8 \times 10^{-5}$ and $B(D^+\rightarrow \pi^+ e^+ e^-) < 6.6 \times 10^{-5}$, at the 90\% confidence level.Comment: nine pages with figures; compressed, uuencoded postscrip

Experimental evidence for a light and broad scalar resonance in D+→π−π+π+D^+\to \pi^-\pi^+\pi^+ decay

From a sample of $1172 \pm 61$ $D^+ \to \pi^- \pi^+ \pi^+$ decay, we find $\Gamma (D^+ \to \pi^- \pi^+ \pi^+) / \Gamma (D^+ \to K^- \pi^+ \pi^+) = 0.0311 \pm 0.0018 ^{+0.0016}_{-0.0026}$. Using a coherent amplitude analysis to fit the Dalitz plot of this decays, we find strong evidence that a scalar resonance of mass $478^{+24}_{-23} \pm 17$ MeV/$c^2$ and width $324^{+42}_{-40} \pm 21$ MeV/$c^2$ accounts for approximately half of all decays.Comment: 10 pages, 3 eps figure

Study of the Ds+→π−π+π+D^+_s \to \pi^- \pi^+ \pi^+ decay and measurement of f0f_0 masses and widths

From a sample of 848 $\pm$ 44 $D_s^+ \to \pi^- \pi^+ \pi^+$ decays, we find $\Gamma(D_s^+ \to \pi^- \pi^+ \pi^+) / \Gamma(D_s^+ \to \phi \pi^+) = 0.245 \pm 0.028^{+0.019}_{-0.012}$. Using a Dalitz plot analysis of this three body decay, we find significant contributions from the channels $\rho^0(770)\pi^+$, $\rho^0(1450)\pi^+$, $f_0(980)\pi^+$, $f_2(1270)\pi^+$, and $f_0(1370)\pi^+$. We present also the values obtained for masses and widths of the resonances $f_0(980)$ and $f_0(1370)$.Comment: 10 pages, 3 eps figure

Direct measurement of the pion valence quark momentum distribution, the pion light-cone wave function squared

We present the first direct measurements of the pion valence quark momentum distribution which is related to the square of the pion light-cone wave function. The measurements were carried out using data on diffractive dissociation of 500 GeV/c $\pi^-$ into di-jets from a platinum target at Fermilab experiment E791. The results show that the $|q\bar {q}>$ light-cone asymptotic wave function, which was developed using perturbative QCD methods, describes the data well for $Q^2 \sim 10 ~{\rm (GeV/c)^2}$ or more. We also measured the transverse momentum distribution of the diffractive di-jets.Comment: 13 pages, 4 figure

Dalitz Plot Analysis of the Decay D^+ --> K^- pi^+ pi^+ and Indication of a Low-Mass Scalar K pi Resonance

We study the Dalitz plot of the decay D^+ --> K^- pi^+ pi^+ with a sample of 15090 events from Fermilab experiment E791. Modeling the decay amplitude as the coherent sum of known K pi resonances and a uniform nonresonant term, we do not obtain an acceptable fit. If we allow the mass and width of the K^*_0(1430) to float, we obtain values consistent with those from PDG but the chi^2 per degree of freedom of the fit is still unsatisfactory. A good fit is found when we allow for the presence of an additional scalar resonance, with mass 797 +/- 19 +/- 43 MeV/c^2 and width 410 +/- 43 +/- 87 MeV/c^2. The mass and width of the K^*_0(1430) become 1459 +/- 7 +/- 5 MeV/c^2 and 175 +/- 12 +/- 12 MeV/c^2, respectively. Our results provide new information on the scalar sector in hadron spectroscopy.Comment: Accepted for publication in Physical Review Letter