92 research outputs found
A Precision Measurement of pp Elastic Scattering Cross Sections at Intermediate Energies
We have measured differential cross sections for \pp elastic scattering with
internal fiber targets in the recirculating beam of the proton synchrotron
COSY. Measurements were made continuously during acceleration for projectile
kinetic energies between 0.23 and 2.59 GeV in the angular range deg. Details of the apparatus and the data analysis are
given and the resulting excitation functions and angular distributions
presented. The precision of each data point is typically better than 4%, and a
relative normalization uncertainty of only 2.5% within an excitation function
has been reached. The impact on phase shift analysis as well as upper bounds on
possible resonant contributions in lower partial waves are discussed.Comment: 23 pages 29 figure
Functional characterisation of the TSC1–TSC2 complex to assess multiple TSC2 variants identified in single families affected by tuberous sclerosis complex
BACKGROUND: Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterised by seizures, mental retardation and the development of hamartomas in a variety of organs and tissues. The disease is caused by mutations in either the TSC1 gene on chromosome 9q34, or the TSC2 gene on chromosome 16p13.3. The TSC1 and TSC2 gene products, TSC1 and TSC2, interact to form a protein complex that inhibits signal transduction to the downstream effectors of the mammalian target of rapamycin (mTOR). METHODS: We have used a combination of different assays to characterise the effects of a number of pathogenic TSC2 amino acid substitutions on TSC1-TSC2 complex formation and mTOR signalling. RESULTS: We used these assays to compare the effects of 9 different TSC2 variants (S132C, F143L, A196T, C244R, Y598H, I820del, T993M, L1511H and R1772C) identified in individuals with symptoms of TSC from 4 different families. In each case we were able to identify the pathogenic mutation. CONCLUSION: Functional characterisation of TSC2 variants can help identify pathogenic changes in individuals with TSC, and assist in the diagnosis and genetic counselling of the index cases and/or other family members
Mesure de quelques sections efficaces (n, α) dans l'intervalle des énergies des neutrons 12 à 19,6 Mev
Cross sections for the reaction 27Al (n, α) 24Na, 51V(n, α) 48Sc, 59Co(n, α) 56Mn and 69Co(n, 2n)58Co were measured for neutron energies betwwen 12 and 19.6 MeV using neutrons of the D(T, n)α-reaction at ED = 3 MeV.Les sections efficaces ont été mesurées pour les réactions 27Al(n, α) 24Na, 51V(n, α)48Sc, 59Co(n, α) 56Mn et 59Co(n, 2n)58Co dans le domaine des énergies des neutrons de 12 à 19,6 MeV
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