1 research outputs found
Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
The subventricular zone (SVZ) provides a constant supply of new neurons to the
olfactory bulb (OB). Different studies have investigated the role of olfactory
sensory input to neural precursor cell (NPC) turnover in the SVZ but it was
not addressed if a reduced demand specifically for periglomerular neurons
impacts on NPC-traits in the rostral migratory stream (RMS). We here report
that membrane type-1 matrix metalloproteinase (MT1-MMP) deficient mice have
reduced complexity of the nasal turbinates, decreased sensory innervation of
the OB, reduced numbers of olfactory glomeruli and reduced OB-size without
alterations in SVZ neurogenesis. Large parts of the RMS were fully preserved
in MT1-MMP-deficient mice, but we detected an increase in cell death-levels
and a decrease in SVZ-derived neuroblasts in the distal RMS, as compared to
controls. BrdU-tracking experiments showed that homing of NPCs specifically to
the glomerular layer was reduced in MT1-MMP-deficient mice in contrast to
controls while numbers of tracked cells remained equal in other OB-layers
throughout all experimental groups. Altogether, our data show the demand for
olfactory interneurons in the glomerular layer modulates cell turnover in the
RMS, but has no impact on subventricular neurogenesis