6 research outputs found
LINPROG: A linear-programming code developed at Risø
- Publication venue
- Risø National Laboratory
- Publication date
- 01/01/1990
- Field of study
Input Files for Computer Simulation of Water Radiolysis
- Publication venue
- Danmarks Tekniske Universitet, Risø Nationallaboratoriet for Bæredygtig Energi
- Publication date
- 01/01/1984
- Field of study
This report contains radiation chemistry input files for CHEMSIMUL, a program package for numerical simulation of Chemical reaction systems
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials
- Author
- Aaronson Keith
- Abadier Rafik
- Abbasi Siddique A.
- Abdullah Shuaib
- Abelson Mark
- Abhayaratna Walter
- Ablasser Klemens
- Aboyans Victor
- Abo‐Auda Wael
- Abuannadi Mohammad
- Adams Kirkwood
- Adams Kirkwood F.
- Adhya Shaumik
- Adler Alexander
- Aggarwala Gaurav
- Agostoni Piergiuseppe
- Ahmad Saad
- Aiub Jorge Roberto
- Al Mohammad Abdallah
- Alharethi Rami
- Alieksieieva Liudmyla
- Almeida Filipa
- Almousalli Omar
- Amano Tetsuya
- Amanullah Aman
- Ambardekar Amrut
- Amerena John
- Anand Inder
- Anderson William
- Ando Kenji
- Andreka Peter
- Antalik Lubomir
- Aradi Daniel
- Araiza Raul Reyes
- Arbolishvili Georgy
- Ariani Mehrdad
- Arias‐Mendoza Alexandra
- Arora Raveen
- Arroyo Julian Alonso Coronel
- Artis Andre
- Asakura Masanori
- Asano Hiroshi
- Ashcom Thomas
- Aslam Shamaila
- Asubiaro Joshua
- Atherton John
- Avaca Horacio Alberto
- Babapulle Mohan
- Bacal Fernando
- Badak Ozer
- Badariene Jolita
- Badat Aysha
- Baker Mathue
- Balsam Pawel
- Banerji Sourin
- Barbarash Olga
- Barbetseas Ioannis
- Barr Craig
- Barros e Silva Pedro Gabriel Melo
- Barua Rajat
- Bauerlein Eugene Joseph
- Baweja Paramdeep
- Bednarkiewicz Zbigniew
- Beelen Driek
- Begg Alistair
- Bekar Lutfu
- Belenkiy Dmitriy
- Belohlavek Jan
- Beltrame John
- Berdague Philippe
- Berglund Stefan
- Berk Martin
- Berkowski Piotr
- Berra Fernando Colombo
- Bertolet Barry
- Besada Diego Alejandro
- Beug Daniel
- Bezzegh Katalin
- Bhagwat Ravi
- Bhargava Rakesh
- Biering‐Sørensen Tor
- Bilato Claudio
- Blicharski Tomasz
- Boccalandro Fernando
- Boehm Michael
- Boehmer John
- Bogaev Roberta
- Bolshakova Olga
- Boman Kurt
- Bonderman Diana
- Bonet Luis Almenar
- Bonfanti Alberto Cadena
- Bordonava Anselmo Paulino
- Bostick Brian
- Boswijk Dirk
- Bourgeois Ronald
- Bourhaial Hakima
- Bouza Manuel
- Braga Joao Carlos
- Brasca Daniela Garcia
- Brinkley Douglas
- Brito Dulce
- Brunetti Natale Daniele
- Bruno Marco Raul Litvak
- Bu Peili
- Burgess Lesley
- Busak Ladislav
- Buynak Robert
- Buysschaert Ian
- Bykov Alexander
- Böhm Michael
- Caccavo Alberto
- Canesin Manoel
- Cardona Jose
- Cardoso Juliano
- Carluccio Erberto
- Carrasco Jose Alfredo Pagola
- Carson Peter
- Castillo Armando Garcia
- Cavallini Claudio
- Cavusoglu Yuksel
- Cech Vladimir
- Celik Ahmet
- Celutkiene Jelena
- Cepelak Michal
- Cerci Rodrigo Julio
- Chandra Lokesh
- Chandrasekaran Badrinathan
- Chang David
- Chaves Renato
- Chehayeb Raja
- Cheirif Jorge
- Chen Guoqin
- Chen Jiyan
- Chmielak Zbigniew
- Chouchane Iman
- Chung Eugene
- Cid Maria Cristina Schnettler
- Civitello Andrew
- Clark Andrew
- Cleland John G.F.
- Clifford Piers
- Coletti Andrew
- Collins John
- Colque Roberto
- Constance Christian
- Contreras Johanna
- Corbalan Ramon
- Corbalan Ramon
- Correa Luis Eduardo Echeverria
- Corredor Miguel Alfredo Moncada
- Cosansu Kahraman
- Costa‐Vitali Atilio
- Cotarlan Vladimir
- Coufal Zdenek
- Cox Jeremy
- Crespo‐Leiro Maria G.
- Cruz Kimberly
- Cubero Javier Segovia
- Cui Hanbin
- Cymerman Krzysztof
- Dahlström Ulf
- Damy Thibaud
- Dauber Ira
- De Geeter Guillaume
- De los Rios Ibarra Manuel Odin
- De Pasquale Carmine
- Decoulx Eric
- Demir Mesut
- Desai Pratik
- Diaz Rafael
- Diaz Rafael
- Diaz Victor Alfonso Jimenez
- Dib Nabil
- Diez Mirta
- Dimov Bojidar
- Doblas Juan Jose Gomez
- Doi Masayuki
- Domae Hiroshi
- Donal Erwan
- Dong Yugang
- Donnelly Patrick
- Dorobantu Maria
- Dovgolis Svetlana
- Doyle Timothy
- Drexel Heinz
- Dronov Dmitry
- Droogne Walter
- Drozdz Jaroslaw
- Duarte Tatiana
- Duengen Hans‐Dirk
- Dujardin Karl
- Dupont Matthias
- Duran Ruben Omar Garcia
- Duzenli Mehmet
- Dzupina Andrej
- Eaton Charles
- Ebato Mio
- Ebelt Henning
- Eberly Arthur
- Ebner Christian
- Echeverria Correa Luis E.
- Elliott James
- Elmahi Einas
- Elvan Arif
- Esperon Guillermo Antonio Llamas
- Ezekowitz Justin
- Ezhov Marat
- Fang James
- Fang James C.
- Farris Neil
- Feitell Scott
- Felker G. Michael
- Fernandez Alberto
- Fernando Ronald
- Ferraz Almir
- Figal Domingo Andres Pascual
- Filho Otavio Coelho
- Filho Pedro Pimentel
- Filippatos Gerasimos
- Fisher Daniel
- Florea Viorel
- Flores Ana Maria De Leon
- Floresta Agata Marina
- Fonseca Candida
- Fonseca Cândida
- Forman Steven
- Forster Tamas
- Fortes Jose Augusto Ribas
- Fourie Nyda
- Franchi Francesco
- Frank Theodore
- Frankenstein Lutz
- Freire Ramon Bover
- Fremont Richard
- French John
- Friedman Keith
- Frigerio Maria
- Friz Hernan Emilio Francisco Polo
- Fu Xin
- Fucili Alessandro
- Fuente Galan Luis
- Fuente Ricardo Alfonso Leon
- Fujii Kenshi
- Fujii Shigeru
- Fujiwara Wakaya
- Fukuzawa Shigeru
- Fulop Peter
- Gabriel George
- Gajardo Victor Areli Saavedra
- Galinier Michel
- Ganeshram Vedampattu
- Ganji Jagadeesh
- Garrido Marcelo Alejandro
- Gass Alan
- Gaudet Daniel
- Geltman Edward
- Gemignani Anthony
- Genth‐Zotz Sabine
- Georges Jean‐Louis
- Giamouzis Grigorios
- Gianfagna Robert
- Giannetti Nadia
- Gilmore Richard
- Giorgeto Flavio Eduardo
- Giraldo Clara Ines Saldarriaga
- Giuca Alina
- Giudici Vittorio
- Glover Jason
- Gogia Harinder
- Gohara Seiichiro
- Gola Zbigniew
- Goloshchekin Boris
- Goncalvesova Eva
- Goncalvesova Eva
- Goncharov Ivan
- Gonsorcik Jozef
- Gonzalez Ricardo Garcia
- Gonzalez Salvador Leon
- Gordon Brian
- Gorodeski Eiran
- Gottlieb Stephen
- Goudev Assen
- Goudev Assen R.
- Gray Wayne
- Grazette Luanda
- Greco Oswaldo
- Grewal Gurinder
- Groote Pascal De
- Gueffet Jean‐Pierre
- Guerrero Rodolfo Andres Ahuad
- Gupta Dinesh
- Gupta Milan
- Guray Umit
- Haddad Tariq
- Haehling Stephan
- Hajko Erik
- Hal John
- Halpern Stephen
- Hametz Craig
- Hamilton Andrew
- Han Qinghua
- Han Yajun
- Handel Franklin
- Hara Hisao
- Harris John
- Hart Hamish
- Hart Terence
- Hartleib Michael
- Hasni Syed
- Hata Yoshiki
- Hattler Brack
- Hearne Steven
- Hedgepeth Chester
- Heilman Karl
- Heitner John
- Henderson David
- Herczeg Bela
- Hermans Walter
- Herzog William
- Hidaka Takayuki
- Hidalgo Mario Yanez
- Higashino Yorihiko
- Hiroi Shitoshi
- Hominal Miguel Angel
- Horacek Thomas
- Houra Marek
- Houston Brian
- Howlett Jonathan G.
- Huang He
- Huber Kurt
- Huelsmann Martin
- Hullin Roger
- Hunter Vernon
- Huynh Thao
- Ibañez Julio
- Ibrahim Hassan
- Indolfi Ciro
- Inomata Takayuki
- Iseki Harukazu
- Ishikawa Masahiro
- Isnard Richard
- Isshiki Takaaki
- Itchhaporia Dipti
- Ito Hiroshi
- Jackson Bruce
- Jacob Binu
- Jadbabaie Farid
- Jaeger Cristiano Pederneiras
- Jaffrani Naseem
- Jalaf Margarita Gertrudis Vejar
- Janik Matthew
- Jankowski Piotr
- Janmohamed Munir
- Jarasuniene Dalia
- Jattin Fernando Manzur
- Javier Julian
- Jeppesen Jorgen
- Jerabek Ondrej
- Jimenez Juan Francisco Delgado
- Jofre Christian Paolo Pincetti
- Jondeau Guillaume
- Jones Alonzo
- Joseph Susan
- Juanatey Jose Ramon Gonzalez
- Judkins Christopher
- Kadel Christoph
- Kadokami Toshiaki
- Kafara Mariusz
- Kai Hisashi
- Kaiser‐Nielsen Peter
- Kajinami Kouji
- Kalarus Zbigniew
- Kalecinska‐Krystkiewicz Ewa
- Kalra Paul
- Kaluski Edo
- Kanda Junji
- Kania Grzegorz
- Kao John
- Karavidas Apostolos
- Karim Amin
- Karlstrom Patric
- Karpenko Oleksandr
- Karvounis Haralambos
- Kasai Toshio
- Kassiotis Christos
- Katz Richard
- Kawakami Hideo
- Kawamitsu Katsunori
- Kawasaki Tomohiro
- Kazemi Navid
- Kazinczy Rita
- Kearney Leighton
- Keeling Philip
- Kellnerova Ivana
- Khalife Wissam
- Kida Keisuke
- Killat Holger
- Kindel Carlos Conejeros
- King Anthony
- Kirma Cevat
- Kitaoka Hiroaki
- Klimsa Zdenek
- Klug Eric
- Kobalava Zhanna
- Kochiadakis George
- Koga Tokushi
- Koike Akihiro
- Koizumi Tomomi
- Koldas Zehra Lale
- Koleckar Pavel
- Komiyama Nobuyuki
- Kondo Nicholas
- Konieczynska Malgorzata
- Kono Alan
- Koo Charles
- Kopaczewski Jerzy
- Korczyk Dariusz
- Koren Michael
- Korzh Oleksii
- Kosmacheva Elena
- Kostenko Viktor
- Kotelnikov Mikhail
- Kowalski Robert
- Kracz Igor
- Krantz Mori
- Krishnamoorthy Arun
- Krupicka Jiri
- Kryza Radim
- Kubota Toru
- Kulibaba Elena
- Kulynych Oleksii
- Kurtz Christopher E.
- Kwan Michael
- Lader Ellis
- Lakatos Ferenc
- Lakshminarayanan Batlagundu
- Lancellotti Patrizio
- Lanfear David E.
- Lang Chim
- Lang Christopher
- Laperche Thierry
- Laszlo Zoltan
- Leaes Paulo Ernesto
- Lefebvre Jean‐Marie
- Legg Jason C.
- Leiro Maria Generosa Crespo
- Lelonek Malgorzata
- Lenartowska Lucyna
- Lenner Egon
- Leon Jose Luis Arenas
- Leonardi Sergio
- Lepor Norman
- LeWinter Martin
- Lewis Neil
- Li Dongye
- Li Jianjun
- Li Tianfa
- Li Weimin
- Li Yinjun
- Li Zhangquan
- Li Zhaoping
- Lighezan Daniel
- Lindholm Carl‐Johan
- Linssen Gerardus
- Liu Feng
- Llamas Edmundo Alfredo Bayram
- Llerena Sara
- Lohr Nicole
- Londono Juan
- Lopez Gabriel Arturo Ramos
- Lopez Luis Horacio Atehortua
- Lopez Rodrigo Botero
- Lovell Charles
- Ludman Andrew
- Luengas Carlos Alberto
- Lukacova Jana
- Lukyanov Yury
- Lund Marianne
- Lund Mayanna
- Lupkovics Geza
- Lupovitch Steven
- Luquez Hugo
- Lymar Yurii
- Lynch Mary
- Ma Shumei
- Macarie Cezar‐Eugen
- Macdonald Peter
- Macdonald Peter
- Machado Gustavo Francisco Mendez
- Machova Vilma
- Macias Leonardo
- Mackinnon Ignacio
- Maejima Yasuhiro
- Magro Michael
- Mahemuti Ailiman
- Mahmood Shahid
- Maia Lilia Nigro
- Majercak Ivan
- Majul Claudio Rodolfo
- Malhotra Sanjay
- Malhotra Vinay
- Malik Adnan
- Malik Fady I.
- Mamdani Shafiq
- Mancini Donna
- Manenti Euler Roberto Fernandes
- Manita Mamoru
- Manolis Athanasios
- Mantas Ioannis
- Mareev Vyacheslav
- Mareev Vyacheslav
- Margoczy Roman
- Margonato Alberto
- Mark Laszlo
- Marquez Lilia Luz Lobo
- Martindale Jeffrey
- Martinez Diego Felipe
- Martinez Laura Jordan
- Martinez Luis
- Martinez‐Arraras Joaquin
- Martinez‐Castrillon Melvin
- Marzouka George
- Masuda Seigo
- Matsumoto Takashi
- Mayer Nolan
- Mayoral Alejandro Recio
- McGrew Frank
- McKelvie Robert
- McKenzie Scott
- McLean Dalton
- McMurray John J.V.
- Menck Niels
- Mendoza Jose Luis Accini
- Mendoza Maria Alexandra Arias
- Merkely Bela
- Metra Marco
- Metra Marco
- Meyer Philippe
- Mi Yafei
- Michishita Ichiro
- Miekus Pawel
- Mielniczuk Lisa
- Mignone John
- Militaru Constantin
- Mincheva Valentina
- Mishchenko Larysa
- Mitrokhin Vladislav
- Mitrovic Veselin
- Mitsuo Kazuhisa
- Mittag Marcus
- Mitu Florin
- Miura Shinichiro
- Miyamoto Michael
- Miyamoto Nobuhide
- Miyazaki Tetsuro
- Moccetti Tiziano
- Mody Freny
- Moe Gordon
- Moertl Deddo
- Mohacsi Attila
- Mohapatra Robert
- Molina Beatriz Diaz
- Momiyama Yukihiko
- Momomura Shin‐ichi
- Monhart Zdenek
- Montana Oscar Romano
- Monteiro Pedro
- Moodley Rajendran
- Mori Masuki
- Morita Yukiko
- Morrow John Andrew
- Mortara Andrea
- Mostovoy Yuriy
- Motovska Zuzana
- Motylev Igor
- Mouhaffel Asad
- Muderrisoglu Ibrahim Haldun
- Mueller Christian
- Murray David
- Muthumala Amal
- Myasnikov Roman
- Nadar Venkatesh
- Nagy Laszlo
- Nair Nandini
- Naka Katerina
- Nakamura Akihiro
- Nakamura Kentaro
- Nalbantgil Sanem
- Nechvatal Libor
- Nelson William
- Nessler Jadwiga
- Nguyen Viviane
- Nicolosi Liliana
- Nielsen Tonny
- Niu Wentang
- Node Koichi
- Noll Georg
- Nosov Vladimir
- Novaretto Leonardo
- Numaguchi Kotaro
- Nyolczas Noemi
- Nyvad Ole
- O'Brien Terrence
- O'Meara Eileen
- O'Meara Eileen
- Ogawa Tomohiro
- Oishi Shogo
- Okishige Kaoru
- Okumura Takahiro
- Okumura Yasuo
- Okuyan Ertugrul
- Oliveira Soares Manue Martinez‐Selles D
- Oliveira Luis
- Olsen Stephanie
- Onoue Kenji
- Onrat Ersel
- Ooi Henry
- Orgera Marisa
- Ortiz Aurelio
- Osipova Irina
- Osorio Wilder Castaño
- Ovize Michel
- Padron Antonio Lara
- Paiva Maria Sanali
- Palomas Juan Luis Bonilla
- Pandey A Shekhar
- Paolino Bruno
- Papp Andras
- Papp Aniko
- Pareja Monica Lopez
- Parissis John
- Parkhomenko Alexander
- Parkhomenko Oleksandr
- Parody Maria Leonor
- Paszczuk Anna
- Patel Devesh
- Patsilinakos Sotirios
- Pauwaa Sunil
- Pawlowicz Lidia
- Paya Vicente Eduardo Climent
- Peart Brenda
- Peiro Maria Teresa Blasco
- Pelaez Sebastian Velez
- Perez Sonia Mirabet
- Perna Eduardo
- Perna Gianpiero
- Pesant Yves
- Peterka Karel
- Peterson Magnus
- Petrov Ivo
- Pfister Roman
- Pham Michael
- Phaneuf Denis‐Carl
- Pianko Leonard
- Piatek Marek
- Picard François
- Pickett Christopher
- Piegas Leopoldo Soares
- Pijanowski Zbigniew
- Pillutla Priya
- Pimenov Leonid
- Pini Daniela
- Piovaccari Giancarlo
- Pisani Barbara
- Podoleanu Cristian Gheorghe
- Podpera Ivo
- Poelzl Gerhard
- Polasek Rostislav
- Ponikowski Piotr
- Popescu Mircea Ioachim
- Portnay Edward
- Postadzhiyan Arman
- Potthoff Sergio
- Poy Carlos
- Pozdisek Zbynek
- Prado Aldo
- Prado Jose Maria Arizon
- Price Dallas
- Prokhorov Oleksandr
- Proulx Guy
- Qu Yanling
- Radin Michael
- Radojevic Joseph
- Rafalskiy Vladimir
- Rahko Peter
- Rajagopalan Navin
- Rama Bhola
- Ramanathan Kodangudi
- Ramires Felix
- Ramires Felix J. A.
- Ramos Mark
- Ranadive Nandkishore
- Randall William
- Rao Sunder
- Rasmussen Mariela
- Rasputina Lesya
- Rassaf Tienush
- Rassi Salvador
- Rawitscher David
- Reis Gilmar
- Remmen Johannes
- Rennyson Stephen
- Repin Alexey
- Ricci Jean Etienne
- Rider James
- Rishko Mykola
- Rivero Mariel
- Robinson Shawn
- Rodriguez Alicia Contreras
- Rojas Pastor Olaya
- Rosamel Yann
- Rossi Paulo Roberto Ferreira
- Rossini Roberta
- Roth Sherryn
- Roubille Francois
- Rowan Christopher
- Roy Debashis
- Rudenko Leonid
- Rudyk Iurii
- Ruiz Alberto Esteban Bazzoni
- Rupka Dennis
- Ryabov Vyacheslav
- Ryding Alisdair
- Rynkiewicz Andrzej
- Römer Tjeerd
- Sabatier Rémi
- Sahin Tayfun
- Sakagami Satoru
- Sakai Tetsuo
- Sakamoto Tomohiro
- Sakata Yasushi
- Salamon Csaba
- Salazar Dora Ines Molina
- Salazar Melchor Alpizar
- Salomone Oscar Alejandro
- Salukhov Vladimir
- Salvat Muriel
- Sampognaro Gregory
- Sandri Marcus
- Santos Luis
- Saraiva Jose Francisco
- Sarmento Pedro Morais
- Sassone Sonia
- Sato Yukihito
- Sauer Andrew
- Savard Daniel
- Sawyer Douglas
- Saxena Sanjeev
- Schaap Jeroen
- Schee Alexandr
- Schiavi Lilia
- Schmalfuss Carsten
- Schnitzler Robert
- Schultz David
- Sciborski Ryszard
- Scott Russell
- Segarra Jorge Leonardo Cobos
- Semenova Irina
- Senaratne Manohara
- Senni Michele
- Sepulveda Alex Mauricio Villablanca
- Serikawa Takeshi
- Serpytis Pranas
- Serpytis Pranas
- Seto Arnold
- Shah Amit
- Shah Anil
- Shah Keyur
- Shah Nishant
- Shandling Adrian
- Sharma Mukesh
- Sharpsten Lucie
- Shayani Steven
- Sherenkov Alexander
- Shilkina Nataliya
- Shimizu Wataru
- Shimomura Mitsuhiro
- Shin Jooyoung
- Shutemova Elena
- Shvarts Yury
- Sichrovsky Tina
- Sidor Mateusz
- Silva Neto Luis Beck
- Silva Rodrigo
- Silveira Fabio
- Simoes Marcus Vinicius
- Simon Marc
- Sinagra Gianfranco
- Sindone Andrew
- Singh Deovrat
- Singh Pradeep
- Siostrzonek Peter
- Sitnikova Maria
- Skaria Binoy
- Skonieczny Grzegorz
- Skopicki Hal
- Skrobakova Janka
- Slapikas Rimvydas
- Sliwa Karen
- Sluis Aize
- Smart Frank
- Smik Rudolf
- Smilde Tom
- Sobkowicz Bozena
- Sochor Karel
- Sokos George
- Solomon Scott D.
- Solovev Oleg
- Souza Weimar Kunz Barroso
- Spacek Rudolf
- Spinar Jindrich
- Spinar Jindrich
- Spinarova Lenka
- Spiridon Marilena Renata
- Spyra Janusz
- Stahl Llyod
- Stamate Sorin
- Stanciulescu Gabriela
- Stanislavchuk Mykola
- Stankiewicz Anna
- Starling Randall
- Stepek David
- Stets Roman
- Stevlik Jan
- Stewart Robert
- Stoddard Marcus
- Straburzynska‐Migaj Ewa
- Strader J Russell
- Styliadis Ioannis
- Störk Stefan
- Sugino Hiroshi
- Sulemanjee Nasir
- Sun Yuemin
- Sussex Bruce
- Suter Thomas
- Suter Thomas M.
- Suzuki Masahiro
- Sverdlov Aaron
- Sweitzer Nancy
- Szabo Barna
- Szakal Imre
- Szasz Gyula
- Szczasny Marcin
- Szto Gregory
- Taggeselle Jens
- Tahirkheli Naeem
- Takagi Atsutoshi
- Takahashi Natsuki
- Takaishi Hiroshi
- Takama Noriaki
- Takata Theodore
- Takeishi Yasuchika
- Takenaka Takashi
- Tallet Julio
- Tanabe Jun
- Tanaka Takahiro
- Tang Huifang
- Tarasov Nikolay
- Tartiere Jean‐Michel
- Tatebe Shunsuke
- Taylor Justin
- Teerlink John R.
- Terasaki Toshiro
- Terasawa Akihiro
- Tereschenko Sergey
- Timofeev Alexander
- Tisheva‐ Gospodinova Snezhanka
- Tocchetti Carlo Gabriele
- Todorov Georgi
- Tognon Alexandre
- Tomcsanyi Janos
- Tomcsanyi Janos
- Toth Kalman
- Treasure Charles
- Trebacz Jaroslaw
- Trevelyan Jasper
- Triana Miguel Urina
- Trichon Benjamin
- Trochu Jean Noel
- Tsabedze Nqoba
- Tsao Lana
- Tseluyko Vira
- Tsioufis Konstantinos
- Tsujimoto Mitsuru
- Tuncer Mustafa
- Turgut Okan Onur
- Tyl Petr
- Tzekova Maria
- Tziakas Dimitrios
- Ueda Yasunori
- Ueno Hideki
- Uhliar Rudolf
- Ujino Keiji
- Uretsky Barry
- Usui Makoto
- Utsu Noriaki
- Vaccari Christopher
- Vakaliuk Igor
- Van Eck Jacob
- Van Kesteren Henricus
- Van Zyl Louis
- Vandekerckhove Hans
- Vandekerckhove Hans
- Vanhecke Thomas
- Varin Claire
- Vasallo Javier
- Vasilev Ivaylo
- Vasilyeva Larysa
- Vaz Garth
- Vazquez Eduardo Salcido
- Vega Mario
- Velikov Chavdar
- Venegas Manuel Eduardo Rodriguez
- Videbaek Lars
- Vidotti Maria Helena
- Vijay Nampalli
- Vilamajo Oscar Alberto Gomez
- Vilchez Francisco Gonzalez
- Villani Giovanni Quinto
- Villoch Mario
- Villota Julio Eduardo Nuñez
- Vinanska Daniela
- Vincenzi Antonella
- Vinereanu Dragos
- Vinereanu Dragos
- Vishnevsky Alexander
- Voevoda Mikhail
- Vogel Daniel
- Voicu Olga‐Cristina
- Volterrani Maurizio
- Voors Adriaan
- Voors Adriaan A.
- Voronkov Leonid
- Vraa Soren
- Wada Atsuyuki
- Wahid Faisal
- Wal Ruud
- Wang Yi
- Wang Zhifang
- Watanabe Naoki
- Wei Yu
- Weir Robin
- Westenfeld Ralf
- Wheeler Matthew
- Whellan David
- Wiggers Henrik
- Wilkett Matt
- Willems Frank
- Williams Celeste
- Wlodarczyk Aleksander
- Wodlin Peter
- Wong Kenneth
- Wozakowska‐Kaplon Beata
- Wu Weiheng
- Yagensky Andriy
- Yamamoto Mitsutaka
- Yan Jing
- Yang Ping
- Yang Xuming
- Yang Zhenyu
- Yeoman Gary
- Yigit Zerrin
- Yilmaz Mehmet B.
- Yoshida Takeshi
- Yoshikawa Masaki
- Yousuf Kabir
- Yuan Zuyi
- Yuge Masaru
- Zabowka Maciej
- Zaca Valerio
- Zaidman Cesar
- Zanetti Fernando Tomas Lanas
- Zannad Faiez
- Zapata Gerardo
- Zdrenghea Dumitru
- Zeman Kamil
- Zeymer Uwe
- Zhang Jinguo
- Zhang Lily
- Zhang Shouyan
- Zhang Xuelian
- Zhang Yuhui
- Zhang Yuqing
- Zheng Yang
- Zheng Zhe
- Zhou Changyong
- Zieroth Shelley
- Zilahi Zsolt
- Zimmet Hendrik
- Zolty Ronald
- Zrazhevskiy Konstantin
- Zwaan Coenraad
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2020
- Field of study
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594).
Conclusions:
GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
Reactions of H2O3 in the pulse-irradiated Fe(II)-O2 system
- Publication venue
- 'AIP Publishing'
- Publication date
- 01/01/1969
- Field of study
Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
- Author
- A Alan Chu
- A Shekhar Pandey
- Aaron Sverdlov
- Abbasi S. A.
- Abdallah Al Mohammad
- Abdul Al-Hesayen
- Adams K. F.
- Adnan Malik
- Adriaan Voors
- Adrian Shandling
- Agata Marina Floresta
- Ahmet Celik
- Ailiman Mahemuti
- Aize van der Sluis
- Akihiro Koike
- Akihiro Nakamura
- Akihiro Terasawa
- Alan Gass
- Alan Kono
- Alan Meholick
- Alberto Caccavo
- Alberto Cadena Bonfanti
- Alberto Esteban Bazzoni Ruiz
- Alberto Fernandez
- Alberto Margonato
- Aldo Prado
- Alejandro Recio Mayoral
- Aleksander Wlodarczyk
- Aleksandra Manolova
- Alessandro Fucili
- Alex Mauricio Villablanca Sepulveda
- Alexander Adler
- Alexander Bykov
- Alexander Parkhomenko
- Alexander Sherenkov
- Alexander Timofeev
- Alexander Vishnevsky
- Alexandr Schee
- Alexandra Arias Mendoza
- Alexandre Tognon
- Alexey Repin
- Alicia Contreras Rodriguez
- Alina Giuca
- Alisdair Ryding
- Alistair Begg
- Almir Ferraz
- Alonzo Jones
- Amal Muthumala
- Aman Amanullah
- Amarinder Bindra
- Amin Karim
- Amin Yehya
- Amit Shah
- Amrut Ambardekar
- Ana Maria De Leon Flores
- Anand I.
- Anays Santana Izquierdo
- Andras Papp
- Andre Artis
- Andrea Mortara
- Andrej Dzupina
- Andres Iñiguez Romo
- Andrew Boyle
- Andrew Civitello
- Andrew Clark
- Andrew Coletti
- Andrew Hamilton
- Andrew Ludman
- Andrew Sauer
- Andrew Sindone
- Andriy Yagensky
- Andrzej Rynkiewicz
- Aniko Papp
- Anil Shah
- Anna Paszczuk
- Anna Stankiewicz
- Anselmo Paulino Bordonava
- Anthony Gemignani
- Anthony King
- Antonella Vincenzi
- Antonio Juan Castro Fernandez
- Antonio Lara Padron
- Apostolos Karavidas
- Arias-Mendoza A.
- Arif Elvan
- Arman Postadzhiyan
- Armando Garcia Castillo
- Arnold Seto
- Arthur Eberly 3rd
- Arun Krishnamoorthy
- Arunima Misra
- Assad Mouhaffel
- Assen Goudev
- Athanasios Manolis
- Atilio Costa-Vitali
- Atsushi Hirayama
- Atsutoshi Takagi
- Atsuyuki Wada
- Attila Mohacsi
- Aurelio Ortiz
- Aysha Badat
- Badrinathan Chandrasekaran
- Balgit Chhokar
- Barbara Pisani
- Barna Szabo
- Barry Bertolet
- Barry H Greenberg
- Barry Uretsky
- Batlagundu Lakshminarayanan
- Beat Knusel
- Beata Wozakowska-Kaplon
- Beatriz Diaz Molina
- Bela Herczeg
- Bela Merkely
- Benjamin Trichon
- Bhola Rama
- Biering-Sorensen T.
- Binoy Skaria
- Binu Jacob
- Bohm M.
- Bojidar Dimov
- Bonderman D.
- Boris Goloshchekin
- Bozena Sobkowicz
- Brack Hattler
- Bradley Weinberg
- Brenda Lemus
- Brenda Peart
- Brian Bostick
- Brian Claggett
- Brian Gordon
- Brian Houston
- Bruce Jackson
- Bruce Sussex
- Bruno Paolino
- Candida Fonseca
- Carl-Johan Lindholm
- Carlo Gabriele Tocchetti
- Carlos Alberto Luengas
- Carlos Arrieta Garcia
- Carlos Conejeros Kindel
- Carlos Poy
- Carmine De Pasquale
- Carol Davila
- Carsten Schmalfuss
- Celeste Williams
- Cesar Zaidman
- Cevat Kirma
- CezarEugen Macarie
- Changyong Zhou
- Charles Eaton
- Charles Koo
- Charles Lovell
- Charles Treasure
- Chavdar Velikov
- Chester Hedgepeth
- Chiara Melloni
- Chim Lang
- Christian Constance
- Christian Ebner
- Christian Mueller
- Christian Paolo Pincetti Jofre
- Christoph Kadel
- Christopher E Kurtz
- Christopher Judkins
- Christopher Lang
- Christopher Pickett
- Christopher Rowan
- Christopher Vaccari
- Christos Kassiotis
- Ciro Indolfi
- Claire Varin
- Clara Ines Saldarriaga Giraldo
- Claudia Raineri
- Claudio Bilato
- Claudio Cavallini
- Claudio Rodolfo Majul
- Cleland J. G. F.
- Coenraad van der Zwaan
- Constantin Militaru
- Corbalan R.
- Craig Barr
- Craig Hametz
- Crespo-Leiro M. G.
- Cristian Gheorghe Podoleanu
- Cristiano Pederneiras Jaeger
- Cristina Danila
- Csaba Salamon
- Dahlstrom U.
- Dalia Jarasuniene
- Dallas Price
- Dalton McLean
- Daniel Aradi
- Daniel Beug
- Daniel Fisher
- Daniel Gaudet
- Daniel Lenihan
- Daniel Lighezan
- Daniel Pauly
- Daniel Savard
- Daniel Vogel
- Daniela Garcia Brasca
- Daniela Pini
- Daniela Vinanska
- Dariusz Korczyk
- David Chang
- David F Kong
- David Henderson
- David Lanfear
- David Murray
- David Rawitscher
- David Schultz
- David Stepek
- David Whellan
- Debashis Roy
- Deddo Moertl
- Denis-Carl Phaneuf
- Dennis Rupka
- Deovrat Singh
- Devesh Patel
- Diana Bonderman
- Diaz R.
- Diego Alejandro Besada
- Diego Felipe Martinez
- Dimitrios Tziakas
- Dinesh Gupta
- Dipti Itchhaporia
- Dirk Boswijk
- Dirk Lok
- Dirk Schellings
- Dmitriy Belenkiy
- Dmitry Dronov
- Dmytro Reshotko
- Domenico Bonaduce
- Domingo Andres Pascual Figal
- Dongye Li
- Donna Mancini
- Dora Ines Molina de Salazar
- Douglas Brinkley
- Douglas Martel
- Douglas Sawyer
- Dragos Vinereanu
- Driek Beelen
- Dulce Brito
- Dumitru Zdrenghea
- Echeverria L. E.
- Edmundo Alfredo Bayram Llamas
- Edo Kaluski
- Eduardo Perna
- Eduardo Salcido Vazquez
- Edward Geltman
- Edward Portnay
- Egon Lenner
- Eileen O'Meara
- Einas Elmahi
- Eiran Gorodeski
- Elena Cowan
- Elena Kosmacheva
- Elena Kulibaba
- Elena Shutemova
- Ellis Lader
- Elvin Kedhi
- Erberto Carluccio
- Eric Decoulx
- Eric Klug
- Erik Hajko
- Ersel Onrat
- Ertugrul Okuyan
- Erwan Donal
- Eugene Chung
- Eugene Joseph Bauerlein
- Euler Roberto Fernandes Manenti
- Eva Goncalvesova
- Eva Peterfai
- Ewa Kalecinska-Krystkiewicz
- Ewa Straburzynska-Migaj
- Fabiana Rollini
- Fabio Silveira
- Fady I Malik
- Faiez Zannad
- Faisal Wahid
- Fang J. C.
- Farid Jadbabaie
- Felice Achilli
- Felix Ramires
- Feng Liu
- Ferenc Lakatos
- Fernando Bacal
- Fernando Boccalandro
- Fernando Colombo Berra
- Fernando Manzur Jattin
- Fernando Soto Loureiro
- Fernando Tomas Lanas Zanetti
- Filipa Almeida
- Filippatos G.
- Flavio Brito
- Flavio Eduardo Giorgeto
- Florence Rothenberg
- Florin Mitu
- Fonseca C.
- Fragkiskos Parthenakis
- Francesco Franchi
- Francisco Gonzalez Vilchez
- Francois Roubille
- Frank McGrew
- Frank Smart
- Frank Willems
- Franklin Handel
- François Picard
- Freny Mody
- Friedrich Fruhwald
- Fumi Yamamoto
- G Michael Felker
- Gabriel Arturo Ramos Lopez
- Gabriela Stanciulescu
- Gabriele Jakl-Kotauschek
- Gaetano Maria De Ferrari
- Garth Vaz
- Gary Yeoman
- Gaurav Aggarwala
- Georg Noll
- George Gabriel
- George Kochiadakis
- George Marzouka
- George Sokos
- Georgi Todorov
- Georgiy Dzyak
- Georgy Arbolishvili
- Gerardo Zapata
- Gerardus Linssen
- Gerasimos Filippatos
- Gerhard Poelzl
- Geza Lupkovics
- Giancarlo Piovaccari
- Gianfranco Sinagra
- Gianpiero Perna
- Gilmar Reis
- Gintare Sakalyte
- Giovanni Geronilla
- Giovanni Quinto Villani
- Giuseppe Ambrosio
- Giuseppe Musumeci
- Glenn Hamroff
- Goncalvesova E.
- Gordon Moe
- Gordon Reeves
- Goudev A. R.
- Gregorio Sanchez Vallejo
- Gregory Sampognaro
- Gregory Szto
- Gregory Thomas
- Grigorios Giamouzis
- Grzegorz Kania
- Grzegorz Skonieczny
- Guillaume De Geeter
- Guillaume Jondeau
- Guillermo Antonio Llamas Esperon
- Guoqin Chen
- Gurinder Grewal
- Gurusher Panjrath
- Gustavo Francisco Mendez Machado
- Guy Proulx
- Gyula Szasz
- Hakima Bourhaial
- Hal Skopicki
- Hamish Hart
- Hanbin Cui
- Hans Vandekerckhove
- Hans-Dirk Duengen
- Haralambos Karvounis
- Harinder Gogia
- Harukazu Iseki
- Hassan Ibrahim
- He Huang
- Heinz Drexel
- Hendrik Zimmet
- Henning Ebelt
- Henricus Van Kesteren
- Henrik Wiggers
- Henry Dargie
- Henry Ooi
- Hernan Emilio Francisco Polo Friz
- Hideki Ueno
- Hideo Izawa
- Hideo Kawakami
- Hideyuki Tsuboi
- Hiroaki Kitaoka
- Hiroaki Kiyokawa
- Hiroki Uehara
- Hiroshi Asano
- Hiroshi Domae
- Hiroshi Ito
- Hiroshi Meno
- Hiroshi Sugino
- Hiroshi Takaishi
- Hiroyuki Kawata
- Hisao Hara
- Hisashi Kai
- Holger Killat
- Honarpour N.
- Horacio Alberto Avaca
- Howlett J. G.
- Hugo Luquez
- Huifang Tang
- Ian Buysschaert
- Ibrahim Haldun Muderrisoglu
- Ichiro Michishita
- Ignacio Mackinnon
- Igor Kraiz
- Igor Motylev
- Igor Vakaliuk
- Iman Chouchane
- Imre Szakal
- Inder Anand
- Inder Singh
- Ioannis Barbetseas
- Ioannis Mantas
- Ioannis Styliadis
- Ira Dauber
- Irina Osipova
- Irina Semenova
- Iurii Rudyk
- Ivan Goncharov
- Ivan Majercak
- Ivana Kellnerova
- Ivaylo Vasilev
- Ivo Petrov
- Ivo Podpera
- J Dedrick Jordan
- J Russell Strader
- Jacob Eifer Moller
- Jacob Van Eck
- Jadwiga Nessler
- Jagadeesh Ganji
- James Elliott
- James Fang
- James L Januzzi
- James Rider
- James Watts
- Jan Belohlavek
- Jan Stevlik
- Jana Lukacova
- Janka Skrobakova
- Janos Tomcsanyi
- Janusz Spyra
- Jaroslaw Drozdz
- Jaroslaw Trebacz
- Jason C Legg
- Jason Glover
- Jasper Trevelyan
- Javed Butler
- Javier Segovia Cubero
- Javier Vasallo
- Jean Etienne Ricci
- Jean-Louis Georges
- Jean-Marie Lefebvre
- Jean-Michel Tartiere
- Jean-Noel Trochu
- Jean-Pierre Gueffet
- Jeffrey Martindale
- Jelena Celutkiene
- Jenica N Upshaw
- Jennifer Cook
- Jens Taggeselle
- Jeremy Cox
- Jeroen Schaap
- Jerzy Kopaczewski
- Jianjun Li
- Jindrich Spinar
- Jing Li
- Jing Yan
- Jinguo Zhang
- Jiri Krupicka
- Jiyan Chen
- Joao Carlos Braga
- Joaquin Martinez-Arraras
- Johanna Contreras
- Johannes Remmen
- John Amerena
- John Andrew Morrow
- John Atherton
- John Beltrame
- John Boehmer
- John Cleland
- John Collins
- John Corbelli
- John French
- John Groarke
- John Harris
- John Heitner
- John J V McMurray
- John Kao
- John Mignone
- John Murray
- John Parissis
- John van Hal
- Jolita Badariene
- Jonathan Howlett
- Jooyoung Shin
- Jorge Cheirif
- Jorge Leonardo Cobos Segarra
- Jorge Roberto Aiub
- Jorgen Jeppesen
- Jose Alfredo Pagola Carrasco
- Jose Augusto Ribas Fortes
- Jose Cardona
- Jose Francisco Saraiva
- Jose Luis Accini Mendoza
- Jose Luis Arenas Leon
- Jose Luis Lambert Rodriguez
- Jose Maria Arizon Del Prado
- Jose Ramon Gonzalez Juanatey
- Joseph Massaro
- Joseph Radojevic
- Joseph Rahman
- Joshua Asubiaro
- Jozef Gonsorcik
- Juan Francisco Delgado Jimenez
- Juan Jose Gomez Doblas
- Juan Londono
- Juan Luis Bonilla Palomas
- Julian Alonso Coronel Arroyo
- Julian Javier
- Juliano Cardoso
- Julio Eduardo Nuñez Villota
- Julio Ibañez
- Julio Tallet
- Jun Tanabe
- Junji Kanda
- Justin Ezekowitz
- Justin Taylor
- Kabir Yousuf
- Kahraman Cosansu
- Kalman Toth
- Kamil Zeman
- Kaoru Okishige
- Karel Peterka
- Karel Sochor
- Karen P Alexander
- Karen Sliwa
- Karl Dujardin
- Karl Heilman
- Katalin Bezzegh
- Katerina Naka
- Katsunori Kawamitsu
- Kazuhisa Mitsuo
- Keiji Ujino
- Keijiro Saku
- Keisuke Kida
- Keith Aaronson
- Keith Friedman
- Kenji Ando
- Kenji Onoue
- Kenneth Wong
- Kenshi Fujii
- Kentaro Nakamura
- Keyur Shah
- Kimberly Cruz
- Kimiaki Nagase
- Kirkwood Adams
- Klemens Ablasser
- Kodangudi Ramanathan
- Koichi Node
- Koichiro Sugimura
- Konstantin Zrazhevskiy
- Konstantinos Tsioufis
- Kotaro Numaguchi
- Kouji Kajinami
- Krzysztof Cymerman
- Kumiko Nakayama
- Kunihiko Makino
- Kurt Boman
- Kurt Huber
- Kurtz C. E. GALACTIC-HF Investigators: John R Teerlink
- Ladislav Busak
- Lana Tsao
- Lanfear D. E.
- Larry Allen
- Lars Videbaek
- Larysa Mishchenko
- Larysa Vasilyeva
- Laszlo Mark
- Laszlo Nagy
- Laura Jordan Martinez
- Laurie Letarte
- Lawrence Galitz
- Lawrence J Lesko
- Legg J. C.
- Leighton Kearney
- Lenka Spinarova
- Leonard Pianko
- Leonardo Macias
- Leonardo Novaretto
- Leonid Pimenov
- Leonid Rudenko
- Leonid Voronkov
- Leopoldo Soares Piegas
- Lesley Burgess
- Lesya Rasputina
- Li J.
- Libor Nechvatal
- Lidia Ana Zytynski Moura
- Lidia Pawlowicz
- Lilia Luz Lobo Marquez
- Lilia Nigro Maia
- Lilia Schiavi
- Liliana Nicolosi
- Lily Zhang
- Lisa Mielniczuk
- Liudmyla Alieksieieva
- Lixin Jiang
- Llyod Stahl
- Lokesh Chandra
- Louis Van Zyl
- Luanda Grazette
- Lubomir Antalik
- Luc Pierard
- Lucie Sharpsten
- Lucyna Lenartowska
- Luis Almenar Bonet
- Luis Beck da Silva Neto
- Luis de la Fuente Galan
- Luis Eduardo Echeverria
- Luis Eduardo Echeverria
- Luis Horacio Atehortua Lopez
- Luis Martinez
- Luis Oliveira
- Luis Santos
- Lund M.
- Lutfu Bekar
- Lutz Frankenstein
- Macdonald P.
- Maciej Zabowka
- Madhusudhan Pamganamamula
- Magnus Peterson
- Mahazarin Ginwalla
- Makoto Nakahama
- Makoto Usui
- Malgorzata Konieczynska
- Malgorzata Lelonek
- Malik F. I.
- Mamoru Manita
- Manoel Canesin
- Manohara Senaratne
- Manuel Bouza
- Manuel Eduardo Rodriguez Venegas
- Manuel Martinez-Selles D Oliveira Soares
- Manuel Odin De Los Rios Ibarra
- Marat Ezhov
- Marc Simon
- Marcelo Alejandro Garrido
- Marcin Szczasny
- Marco Metra
- Marcos Amuchastegui
- Marcos Raul Litvak Bruno
- Marcus Mittag
- Marcus Sandri
- Marcus Stoddard
- Marcus Vinicius Simoes
- Mareev V.
- Marek Houra
- Marek Piatek
- Margarita Gertrudis Vejar Jalaf
- Maria Alexandra Arias Mendoza
- Maria Cristina Schnettler Cid
- Maria Dorobantu
- Maria Frigerio
- Maria Generosa Crespo Leiro
- Maria Helena Vidotti
- Maria Leonor Parody
- Maria Sanali Paiva
- Maria Sitnikova
- Maria Teresa Blasco Peiro
- Maria Tzekova
- Mariel Rivero
- Mariela Rasmussen
- Marilena Renata Spiridon
- Mario Vega
- Mario Villoch
- Mario Yanez Hidalgo
- Marisa Crespo Leiro
- Marisa Orgera
- Mariusz Kafara
- Mark Abelson
- Mark Ramos
- Mark Smith
- Mark Zucker
- Martin Berk
- Martin Huelsmann
- Martin LeWinter
- Marvin A Konstam
- Mary Lynch
- Masahiro Ishikawa
- Masahiro Suzuki
- Masaki Yoshikawa
- Masanori Asakura
- Masaru Yuge
- Masayoshi Ajioka
- Masayuki Doi
- Masuki Mori
- Mateusz Sidor
- Mathue Baker
- Matt Wilkett
- Matteo Di Biase
- Matthew Janik
- Matthew Wheeler
- Matthias Dupont
- Maurizio Volterrani
- Mayanna Lund
- McMurray J. J. V.
- Mehmet Birhan Yilmaz
- Mehmet Birhan Yilmaz
- Mehmet Duzenli
- Mehrdad Ariani
- Melchor Alpizar Salazar
- Melvin Martinez-Castrillon
- Mesut Demir
- Metra M.
- Michael Boehm
- Michael Böhm
- Michael Felker G.
- Michael Hartleib
- Michael Koren
- Michael Kwan
- Michael Magro
- Michael Miyamoto
- Michael Pham
- Michael Radin
- Michal Cepelak
- Michel Galinier
- Michel Ovize
- Michele Hamilton
- Michele Senni
- Miguel Alfredo Moncada Corredor
- Miguel Angel Hominal
- Miguel Urina Triana
- Mikhail Kotelnikov
- Mikhail Voevoda
- Milan Gupta
- Mio Ebato
- Mircea Ioachim Popescu
- Mirta Diez
- Mitsuhiro Shimomura
- Mitsuru Tsujimoto
- Mitsutaka Yamamoto
- Mohammad Abuannadi
- Mohan Babapulle
- Momomura S.
- Monica Lopez Pareja
- Mori Krantz
- Mukesh Sharma
- Munir Janmohamed
- Muriel Salvat
- Mustafa Tuncer
- Mustafa Vural
- Mykola Rishko
- Mykola Stanislavchuk
- Nabil Dib
- Nadia Giannetti
- Naeem Tahirkheli
- Nampalli Vijay
- Nancy Sweitzer
- Nandini Nair
- Nandkishore Ranadive
- Naoki Sato
- Naoki Watanabe
- Narimon Honarpour
- Naseem Jaffrani
- Nasir Sulemanjee
- Natale Daniele Brunetti
- Nataliya Shilkina
- Nathan Mewton
- Natsuki Takahashi
- Navid Kazemi
- Navin Rajagopalan
- Neil Farris
- Neil Lewis
- Nicholas Kondo
- Nicole Lohr
- Niels Gadsboll
- Niels Menck
- Nikolay Tarasov
- Nishant Shah
- Nobuhide Miyamoto
- Nobuyuki Komiyama
- Noemi Nyolczas
- Nolan Mayer
- Norberto Duda
- Noriaki Takama
- Noriaki Utsu
- Norman Lepor
- Nqoba Tsabedze
- Nyda Fourie
- O'Meara E.
- Okan Onur Turgut
- Ole Nyvad
- Oleg Solovev
- Oleksandr Karpenko
- Oleksandr Parkhomenko
- Oleksandr Prokhorov
- Oleksii Korzh
- Oleksii Kulynych
- Olga Barbarash
- Olga Bolshakova
- Olga-Cristina Voicu
- Omar Almousalli
- Ondrej Jerabek
- Oscar Alberto Gomez Vilamajo
- Oscar Alejandro Salomone
- Oscar Romano Montana
- Oswaldo Greco
- Oswaldo Sandoval
- Otavio Coelho Filho
- Ozer Badak
- Paramdeep Baweja
- Parkhomenko A.
- Pascal De Groote
- Pascalle van Huysduynen-Monraats
- Pastor Olaya Rojas
- Patric Karlstrom
- Patrick Davey
- Patrick Donnelly
- Patrizio Lancellotti
- Paul Kalra
- Paulo Ernesto Leaes
- Paulo Roberto Ferreira Rossi
- Pavel Koleckar
- Pawel Balsam
- Pawel Miekus
- Pedro Gabriel Melo de Barros E Silva
- Pedro Monteiro
- Pedro Morais Sarmento
- Pedro Pimentel Filho
- Peili Bu
- Peter Andreka
- Peter Carson
- Peter Fulop
- Peter Kaiser-Nielsen
- Peter Macdonald
- Peter Rahko
- Peter Siostrzonek
- Peter Wodlin
- Petr Tyl
- Philip Haines
- Philip Keeling
- Philippe Berdague
- Philippe Meyer
- Piergiuseppe Agostoni
- Piers Clifford
- Ping Yang
- Piotr Berkowski
- Piotr Jankowski
- Piotr Ponikowski
- Ponikowski P.
- Pradeep Singh
- Pranas Serpytis
- Pratik Desai
- Priya Pillutla
- Qinghua Han
- Radim Kryza
- Rafael Diaz
- Rafael Díaz
- Rafael Luiz Rech
- Rafik Abadier
- Raja Chehayeb
- Rajat Barua
- Rajendra H Metha
- Rajendran Moodley
- Rajesh Sharma
- Rakesh Bhargava
- Ralf Westenfeld
- Rami Alharethi
- Ramires F. J. A.
- Ramon Bover Freire
- Ramon Corbalan
- Ramon Corbalan Herreros
- Randall Starling
- Raul Reyes Araiza
- Raveen Arora
- Ravi Bhagwat
- Renato Chaves
- Renato Lopes
- Ricardo Alfonso Leon de la Fuente
- Ricardo Garcia Gonzalez
- Richard Fremont
- Richard Gilmore
- Richard Isnard
- Richard Katz
- Rimvydas Slapikas
- Rita Kazinczy
- Robert Buynak
- Robert Gianfagna
- Robert Kowalski
- Robert McKelvie
- Robert Mohapatra
- Robert Schnitzler
- Robert Stewart
- Robert W Harrison
- Robert W McGarrah
- Roberta Bogaev
- Roberta Rossini
- Roberto Colque
- Robin Mathews
- Robin Weir
- Rodolfo Andres Ahuad Guerrero
- Rodrigo Botero Lopez
- Rodrigo da Silva
- Rodrigo Julio Cerci
- Roger Hullin
- Roman Margoczy
- Roman Myasnikov
- Roman Pfister
- Roman Stets
- Ronald Bourgeois
- Ronald Fernando
- Ronald Zolty
- Rosario Santa Fe
- Rostislav Polasek
- Ruben Omar Garcia Duran
- Rudolf Smik
- Rudolf Spacek
- Rudolf Uhliar
- Russell Scott
- Ruud van de Wal
- Ryszard Sciborski
- Rémi Sabatier
- Saad Ahmad
- Sabine Genth-Zotz
- Salvador Leon Gonzalez
- Salvador Rassi
- Sana M Al-Khatib
- Sandra Chaparro
- Sanem Nalbantgil
- Sanjay Malhotra
- Sanjeev Saxena
- Sara Llerena
- Sara Soares Goncalves
- Satoru Sakagami
- Scott D Solomon
- Scott Feitell
- Scott Franczek
- Scott McKenzie
- Sebastian Velez Pelaez
- Seigo Masuda
- Seiichiro Gohara
- Sergey Boytsov
- Sergey Tereschenko
- Sergio Leonardi
- Sergio Potthoff
- Serpytis P.
- Shafiq Mamdani
- Shahid Mahmood
- Shamaila Aslam
- Sharpsten L.
- Shaumik Adhya
- Shawn Robinson
- Shelley Zieroth
- Sherryn Roth
- Shigeru Fujii
- Shigeru Fukuzawa
- Shin-Ichi Momomura
- Shinichiro Miura
- Shitoshi Hiroi
- Shogo Oishi
- Shouyan Zhang
- Shreyansh Shah
- Shuaib Abdullah
- Shuichi Taguchi
- Shumei Ma
- Shunsuke Tatebe
- Shuntaro Kagiyama
- Siddique Abbasi
- Silvia Lopez Fernandez
- Sliwa K.
- Snezhanka Tisheva-Gospodinova
- Solomon S. D.
- Sonia Mirabet Perez
- Sonia Sassone
- Soren Vraa
- Sorin Stamate
- Sotirios Patsilinakos
- Sourin Banerji
- Spinar J.
- Stavros Drakos
- Stefan Berglund
- Stefan Störk
- Stephan von Haehling
- Stephanie Olsen
- Stephen Gottlieb
- Stephen Halpern
- Stephen Rennyson
- Steven Forman
- Steven Hearne
- Steven Krueger
- Steven Lupovitch
- Steven Shayani
- Sunder Rao
- Sunil Pauwaa
- Susan Joseph
- Suter T. M.
- Svetlana Dovgolis
- Svetlana Villevalde
- Syed Hasni
- Takaaki Isshiki
- Takahiro Okumura
- Takahiro Tanaka
- Takashi Matsumoto
- Takashi Takenaka
- Takayuki Hidaka
- Takayuki Inomata
- Takeshi Serikawa
- Takeshi Yoshida
- Tamas Forster
- Tariq Haddad
- Tatiana Duarte
- Tayfun Sahin
- Teerlink J. R.
- Terence Hart
- Terrence O'Brien
- Tetsuo Sakai
- Tetsuro Miyazaki
- Tetsuya Amano
- Thao Huynh
- Theodore Frank
- Theodore Takata
- Thibaud Damy
- Thierry Laperche
- Thomas Ashcom
- Thomas Duythuc To
- Thomas Horacek
- Thomas Hucko
- Thomas J Povsic
- Thomas Suter
- Thomas Vanhecke
- Tianfa Li
- Tienush Rassaf
- Timothy Doyle
- Tina Sichrovsky
- Tiziano Moccetti
- Tjeerd Römer
- Tokushi Koga
- Tom Smilde
- Tomas Brabec
- Tomasz Blicharski
- Tomasz Borkowski
- Tomcsanyi J.
- Tomohiro Kawasaki
- Tomohiro Ogawa
- Tomohiro Sakamoto
- Tomomi Koizumi
- Tonny Nielsen
- Tor Biering-Sørensen
- Toru Kubota
- Toshiaki Kadokami
- Toshio Kasai
- Toshiro Terasaki
- Ulf Dahlstrom
- Umit Guray
- Uwe Zeymer
- Valentina Mincheva
- Valerio Zaca
- Valery Popov
- Vandekerckhove H.
- Varin C.
- Vasilios Papademetriou
- Vedampattu Ganeshram
- Venkatesh Nadar
- Vernon Hunter
- Veselin Mitrovic
- Viacheslav Mareev
- Vicente Eduardo Climent Paya
- Victor Aboyans
- Victor Alfonso Jimenez Diaz
- Victor Areli Saavedra Gajardo
- Viktor Kostenko
- Vilma Machova
- Vinay Malhotra
- Vinay Thohan
- Vinereanu D.
- Viorel Florea
- Vira Tseluyko
- Vittorio Giudici
- Viviane Nguyen
- Vladimir Cech
- Vladimir Cotarlan
- Vladimir Nosov
- Vladimir Rafalskiy
- Vladimir Salukhov
- Vladislav Mitrokhin
- Voors A. A.
- Vyacheslav Mareev
- Vyacheslav Ryabov
- W Schuyler Jones
- Wael AboAuda
- Wakaya Fujiwara
- Walter Abhayaratna
- Walter Droogne
- Walter Hermans
- Wataru Shimizu
- Wayne Gray
- Weiheng Wu
- Weimar Kunz Barroso de Souza
- Weimin Li
- Wentang Niu
- Wilder Castaño Osorio
- William Anderson
- William Herzog
- William Nelson
- William Randall
- Wissam Khalife
- Xin Fu
- Xuelian Zhang
- Xuming Yang
- Yafei Mi
- Yajun Han
- Yang Zheng
- Yanling Qu
- Yann Rosamel
- Yasuchika Takeishi
- Yasuhiro Maejima
- Yasuki Kihara
- Yasunori Ueda
- Yasuo Okumura
- Yasushi Sakata
- Yevgeniya Svishchenko
- Yi Wang
- Yilmaz M. B.
- Yinjun Li
- Yorihiko Higashino
- Yoshihiko Saito
- Yoshiki Hata
- Yoshinori Yasaka
- Yoshitoshi Urabe
- Yu Wei
- Yuemin Sun
- Yugang Dong
- Yuhui Zhang
- Yuji Nakazato
- Yukihiko Momiyama
- Yukihito Sato
- Yukiko Morita
- Yuksel Cavusoglu
- Yuqing Zhang
- Yurii Lymar
- Yuriy Mostovoy
- Yury Lukyanov
- Yury Shvarts
- Yutaka Akatsuka
- Yves Pesant
- Zannad F.
- Zbigniew Bednarkiewicz
- Zbigniew Chmielak
- Zbigniew Gola
- Zbigniew Kalarus
- Zbigniew Pijanowski
- Zbynek Pozdisek
- Zdenek Coufal
- Zdenek Klimsa
- Zdenek Monhart
- Zehra Lale Koldas
- Zerrin Yigit
- Zhanna Kobalava
- Zhanquan Li
- Zhaoping Li
- Zhe Zheng
- Zhenyu Yang
- Zhifang Wang
- Zoltan Laszlo
- Zsolt Zilahi
- Zuyi Yuan
- Zuzana Motovska
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016 -002299-28.)
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial
- Author
- Abbott J
- Abe Mitsuru
- Abouglila Kamal
- Abrahamovych Orest
- Abu-Fadel Mazen
- Accini Jose
- Acikel Sadik
- Adhyapak Srilakshmi
- Agaiby John
- Aggarwala Guarav
- Aguilera Roberto M
- Ahn Taehoon
- Aksentiev Sergei
- Akyea-Djamson Ayim
- Al-Amin Jessie
- Al-Faleh Hussam
- Al-Saif Shukri
- Al-Shehri Abdullah
- Al-Zoebi Ayham
- Aladellie Layth
- Albisu Juan
- Alfata Sarab
- Alshehri Halia
- Alvarado Odilon
- Alvarez Jose
- Alvarisqueta Andres
- Amerena John
- Amerena John
- Amin Amit
- Amoroso Giovanni
- Andersson Marielle
- Andersson Marielle
- Andersson Marielle
- Andrawis Nabil
- Andries Alin
- Andrássy Péter
- Angerås Oskar
- Angiolillo Dominick
- Angoulvant Denis
- Ansari Saadat
- Antalik Lubomir
- Aoyama Takahiko
- Appel Karl-Friedrich
- Arana Camilo
- Arat Alev
- Arbanil Hugo
- Arora Satish
- Arriagada German
- Arshad Tamjeed
- Arslan Sakir
- Arvind Moogali
- Arya Ktut
- Asenjo Roberto M
- Asfour Wail
- Askar Alfredo N
- Assanelli Emilio
- Atieh Mahmoud
- Auer Johann
- Avino David
- Babapulle Mohan
- Babilonia Noe
- Babilonia Noe A
- Bae Jang-Whan
- Baglikov Andrey
- Bailey Allan
- Bailey Gordon
- Bain Stephen
- Bakai Judit
- Bakhtari Ladan
- Ballyuzek Marina
- Bander Jeffrey
- Bandh Stellan
- Banerjee Subhash
- Banerjee Supratim
- Banerjee Suvro
- Barabashkina Anna
- Baracioli Luciano
- Barbarash Olga
- Barbas Benny
- Barettella Mark
- Bashkin Amir
- Basiak Marcin
- Baszak Jacek
- Bata Iqbal
- Bauer Michael
- Bayat Junaid
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- Bednarova Jana
- Behnke Thomas
- Bell Alan
- Belle-Isle Jasmin
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- Belohlavek Jan
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- Berger Rudolf
- Berrospi Percy
- Bertolet Barry
- Bertrand Olivier
- Bertsch John
- Besada Diego
- Bessoudo Ricardo
- Beth Mary
- Bhargava Anuj
- Bhatt Deepak L
- Bhatt Deepak L
- Bhavsar Janak
- Bijata-Bronisz Renata
- Bittar George
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- Blagden Mark
- Blanco Antonio
- Blick David
- Bochenek Anna
- Boldueva Svetlana
- Bolshoun David
- Bonansea Teresa C
- Bongo Angelo S
- Bordonava Anselmo
- Borges Joao
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- Carda Jiri
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- Carrasco Jose P
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- Chag Milan
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- Chang Kuan-Cheng
- Chatrathi Sridhar
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- Chehayeb Raja
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- Chen Jersey
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- Chen Zhih-Cherng
- Chernyavsky Alexander
- Cheung Deanna
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- Chhabra Anil
- Chiang Chern
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- DeGregorio Michele
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- del Blanco Bruno G
- Delforge Marc
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- Figueroa Christian
- Fil Wojciech
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- Fontaine Caroline
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- Goodfellow Ross
- Gordon Paul
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- Goube Pascal
- Gowdaiah Prakash
- Graham Bruce
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- Gravdal Stein A
- Green Sandy
- Greenberg Gabriel
- Grena Paul
- Greschik István
- Gring Christian
- Grunfeldova Hana
- Guedes Antoine
- Guerra Yamirka D
- Guerrero Diego B
- Guillen Mario
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- Harrington Robert A
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- Hollanders Geert
- Holmvang Lene
- Hominal Miguel
- Hong Soon J
- Honkova Michaela
- Hoosen Farzana
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- Yagensky Andriy
- Yakushin Sergey
- Yalcin Ahmet
- Yamamoto Fumi
- Yaneva Zdravka
- Yeh Hung-I
- Ying Man
- Yokoya Koichi
- Yoon Junghan
- Young Douglas
- Younis Liwa
- Yuan Zuyi
- Zadra Remo
- Zakharov Konstantin
- Zakhary Bosh
- Zaman Azfar
- Zamorano Gómez José L
- Zangroniz Pedro
- Zaniewski Michelle
- Zanini Alejandra
- Zarich Stuart
- Zateyschikova Anna
- Zateyshchikov Dmitry A
- Zebrack James
- Zelazowska Katarzyna
- Zhang Aidong
- Zhang Jian
- Zhang Ningru
- Zhang Wenwu
- Zhao Qiang
- Zhao Qiang
- Zhao Xue-Qiao
- Zharinova Viktoria
- Zidkova Eva
- Zilahi Zsolt
- Zinka Elzbieta
- Zonova Elena
- Zubeeva Galina
- Zucconi-Mazzini Roberto
- Zurakowski Aleksander
- Zólyomi Szilárd
- Édes István
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
Methods:
The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population).
Findings:
Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI.
Interpretation:
In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk