Designing the eatwell week: the application of eatwell plate advice to weekly food intake

<p>To develop a menu and resource to illustrate to consumers and health professionals what a healthy balanced diet looks like over the course of a week.</p> <p>Development and analysis of an illustrative 7 d ‘eatwell week’ menu to meet current UK recommendations for nutrients with a Dietary Reference Value, with a daily energy base of 8368 kJ (2000 kcal). Foods were selected using market research data on meals and snacks commonly consumed by UK adults. Analysis used the food composition data set from year 1 (2008) of the UK National Diet and Nutrition Survey rolling programme. The eatwell week menu was developed using an iterative process of nutritional analysis with adjustments made to portion sizes and the inclusion/exclusion of foods in order to achieve the target macronutrient composition.</p> <p>Three main meals and two snacks were presented as interchangeable within the weekdays and two weekend days to achieve adult food and nutrient recommendations. Main meals were based on potatoes, rice or pasta with fish (two meals; one oily), red meat (two meals), poultry or vegetarian accompaniments. The 5-a-day target for fruit and vegetables (range 5–6·7 portions) was achieved daily. Mean salt content was below recommended maximum levels (<6 g/d). All key macro- and micronutrient values were achieved.</p> <p>Affordable foods, and those widely consumed by British adults, can be incorporated within a 7 d healthy balanced menu. Future research should investigate the effect of using the eatwell week on adults’ dietary habits and health-related outcomes.</p&gt

High-resolution thermal expansion measurements under Helium-gas pressure

We report on the realization of a capacitive dilatometer, designed for high-resolution measurements of length changes of a material for temperatures 1.4 K $\leq T \leq$ 300 K and hydrostatic pressure $P \leq$ 250 MPa. Helium ($^4$He) is used as a pressure-transmitting medium, ensuring hydrostatic-pressure conditions. Special emphasis has been given to guarantee, to a good approximation, constant-pressure conditions during temperature sweeps. The performance of the dilatometer is demonstrated by measurements of the coefficient of thermal expansion at pressures $P \simeq$ 0.1 MPa (ambient pressure) and 104 MPa on a single crystal of azurite, Cu$_3$(CO$_3$)$_2$(OH)$_2$, a quasi-one-dimensional spin S = 1/2 Heisenberg antiferromagnet. The results indicate a strong effect of pressure on the magnetic interactions in this system.Comment: 8 pages, 7 figures, published in Rev. Sci. Instrum with minor change

Performance of Hamamatsu 64-anode photomultipliers for use with wavelength--shifting optical fibres

Hamamatsu R5900-00-M64 and R7600-00-M64 photomultiplier tubes will be used with wavelength--shifting optical fibres to read out scintillator strips in the MINOS near detector. We report on measurements of the gain, efficiency, linearity, crosstalk, and dark noise of 232 of these PMTs, of which 219 met MINOS requirements.Comment: 15 pages, 12 figures. Accepted by Nucl. Inst. Meth.

Stable isochronal synchronization of mutually coupled chaotic lasers

The dynamics of two mutually coupled chaotic diode lasers are investigated experimentally and numerically. By adding self feedback to each laser, stable isochronal synchronization is established. This stability, which can be achieved for symmetric operation, is essential for constructing an optical public-channel cryptographic system. The experimental results on diode lasers are well described by rate equations of coupled single mode lasers

The edentulous patient: attitudes toward oral health status

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75662/1/j.1754-4505.1983.tb01340.x.pd

Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster

Multicopper ferroxidases catalyze the oxidation of ferrous iron to ferric iron. In yeast and algae, they participate in cellular uptake of iron; in mammals, they facilitate cellular efflux. The mechanisms of iron metabolism in insects are still poorly understood, and insect multicopper ferroxidases have not been identified. In this paper we present evidence that Drosophila melanogaster multicopper oxidase-1 (MCO1) is a functional ferroxidase. We identified candidate iron binding residues in the MCO1 sequence and found that purified recombinant MCO1 oxidizes ferrous iron. An association between MCO1 function and iron homeostasis was confirmed by two observations: RNAi-mediated knockdown of MCO1 resulted in decreased iron accumulation in midguts and whole insects, and weak knockdown increased the longevity of flies fed a toxic concentration of iron. Strong knockdown of MCO1 resulted in pupal lethality, indicating that MCO1 is an essential gene. Immunohistochemistry experiments demonstrated that MCO1 is located on the basal surfaces of the digestive system and Malpighian tubules. We propose that MCO1 oxidizes ferrous iron in the hemolymph and that the resulting ferric iron is bound by transferrin or melanotransferrin leading to iron storage, iron withholding from pathogens, regulation of oxidative stress and/or epithelial maturation. These proposed functions are distinct from those of other known ferroxidases Given that MCO1 orthologs are present in all insect genomes analyzed to date, this discovery is an important step toward understanding iron metabolism in insects

Comparison of the clonality of urothelial carcinoma developing in the upper urinary tract and those developing in the bladder

PURPOSE: To identify the origin of synchronous and metachronous urothelial carcinoma (UC) of the bladder and upper urinary tract to get a better understanding of the basic mechanism behind the multifocality of UC, which may provide a sound bases for the future development of new strategies for detection, prevention and therapy. METHODS: Six patients with UC of the bladder and synchronous or metachronous UC of the upper urinary tract were studied. Genetic analysis involving the study of loss of heterozygosity (LOH) has been evaluated on their tumours using well characterised and new markers of UC (D9S171, D9S177, D9S303 and TP53). RESULTS: Five of the six patients demonstrated informative results. Four of five (80%) of patients had synchronous or metacharonous UC tumour and showed patterns of LOH consistent with tumorigenesis from monoclonal tumour origin. One of five (20%) patients exhibited a LOH consistent with oligoclonal tumorigenesis. CONCLUSION: These findings suggest that both the monoclonal and field cancerization theory of tumorigenesis may play a role in tumors of the urothelial tract. However, more data is needed

An Analysis of Model-Driven Web Engineering Methodologies

In the late 1990’s there was substantial activity within the “Web engineering” research community and a multitude of new Web approaches were proposed. However, numerous studies have revealed major gaps in these approaches, including coverage and interoperability. In order to address these gaps, the Model-Driven Engineering (MDE) paradigm offers a new approach which has been demonstrated to achieve good results within applied research environments. This paper presents an analysis of a selection of Web development methodologies that are using the MDE paradigm in their development process and assesses whether MDE can provide an effective solution to address the aforementioned problems. This paper presents a critical review of previous studies of classical Web methodologies and makes a case for the potential of the MDWE paradigm as a means of addressing long-standing problems of Web development, for both research and enterprise. A selection of the main MDWE development approaches are analyzed and compared in accordance with criteria derived from the literature. The paper concludes that this new trend opens an interesting new way to develop Web systems within practical projects and argues that some classical gaps can be improved with MDWE.Ministerio de Educación y Ciencia TIN2010-12312-EJunta de Andalucía TIC-578