46 research outputs found
Quantum decision making by social agents
The influence of additional information on the decision making of agents, who
are interacting members of a society, is analyzed within the mathematical
framework based on the use of quantum probabilities. The introduction of social
interactions, which influence the decisions of individual agents, leads to a
generalization of the quantum decision theory developed earlier by the authors
for separate individuals. The generalized approach is free of the standard
paradoxes of classical decision theory. This approach also explains the
error-attenuation effects observed for the paradoxes occurring when decision
makers, who are members of a society, consult with each other, increasing in
this way the available mutual information. A precise correspondence between
quantum decision theory and classical utility theory is formulated via the
introduction of an intermediate probabilistic version of utility theory of a
novel form, which obeys the requirement that zero-utility prospects should have
zero probability weights.Comment: This paper has been withdrawn by the authors because a much extended
and improved version has been submitted as arXiv:1510.02686 under the new
title "Role of information in decision making of social agents
High-Grade B-cell Lymphoma, Not Otherwise Specified: A Multi-Institutional Retrospective Study
In this multi-institutional retrospective study, we examined the characteristics and outcomes of 160 patients with high-grade B-cell lymphoma, not otherwise specified (HGBL-NOS)-a rare category defined by high-grade morphologic features and lack of MYC rearrangements with BCL2 and/or BCL6 rearrangements ( double hit ). Our results show that HGBL-NOS tumors are heterogeneous: 83% of patients had a germinal center B-cell immunophenotype, 37% a dual-expressor immunophenotype (MYC and BCL2 expression), 28% MYC rearrangement, 13% BCL2 rearrangement, and 11% BCL6 rearrangement. Most patients presented with stage IV disease, a high serum lactate dehydrogenase, and other high-risk clinical factors. Most frequent first-line regimens included dose-adjusted cyclophosphamide, doxorubicin, vincristine, and etoposide, with rituximab and prednisone (DA-EPOCH-R; 43%); rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP; 33%); or other intensive chemotherapy programs. We found no significant differences in the rates of complete response (CR), progression-free survival (PFS), or overall survival (OS) between these chemotherapy regimens. CR was attained by 69% of patients. PFS at 2 years was 55.2% and OS was 68.1%. In a multivariable model, the main prognostic factors for PFS and OS were poor performance status, lactate dehydrogenase \u3e3 × upper limit of normal, and a dual-expressor immunophenotype. Age \u3e60 years or presence of MYC rearrangement were not prognostic, but patients with TP53 alterations had a dismal PFS. Presence of MYC rearrangement was not predictive of better PFS in patients treated with DA-EPOCH-R vs R-CHOP. Improvements in the diagnostic criteria and therapeutic approaches beyond dose-intense chemotherapy are needed to overcome the unfavorable prognosis of patients with HGBL-NOS
Comparison of bortezomib- and lenalidomide-based therapies for the treatment of primary (AL) amyloidosis.
Determining farm-scale site-specific monetary values of “soil carbon hotspots” based on avoided social costs of CO 2
Ibrutinib-associated Arthralgias/Myalgias in Patients With Chronic Lymphocytic Leukemia: Incidence and Impact on Clinical Outcomes
© 2020 Elsevier Inc. Ibrutinib-associated arthralgias/myalgias are a frequent adverse event that can occur late in the treatment course and are mostly grade 1 or 2. For patients with grade 1 or 2 arthralgias/myalgias, dose reductions can frequently mitigate the side effects and allow patients to continue on therapy, whereas the majority of patients with grade 3 toxicity ultimately discontinue therapy. Further study is needed to determine their pathogenesis in order to develop best practice management strategies