67 research outputs found
A consistent explanation for C/C, Li, and He anomalies in red giant stars
The observations of carbon isotopic ratios in evolved stars suggest that non
standard mixing is acting in low mass stars as they are ascending the red giant
branch. We propose a simple consistent mechanism, based on the most recent
developments in the description of rotation-induced mixing by Zahn (1992),
which simultaneously accounts for the low C/C ratios in globular
cluster and field Pop II giants and for the lithium abundances in metal-poor
giant stars. It also leads to the destruction of He produced on the main
sequence in low mass stars. This should both naturally account for the recent
measurements of He/H in galactic HII regions and allow for high values of
He observed in some planetary nebulae.Comment: 3 pages plus 2 figures, uses aaspp.sty; offprint requests to :
[email protected]
Nucleosynthesis in Massive Stars With Improved Nuclear and Stellar Physics
We present the first calculations to follow the evolution of all stable
nuclei and their radioactive progenitors in stellar models computed from the
onset of central hydrogen burning through explosion as Type II supernovae.
Calculations are performed for Pop I stars of 15, 19, 20, 21, and 25 M_sun
using the most recently available experimental and theoretical nuclear data,
revised opacity tables, neutrino losses, and weak interaction rates, and taking
into account mass loss due to stellar winds. A novel ``adaptive'' reaction
network is employed with a variable number of nuclei (adjusted each time step)
ranging from about 700 on the main sequence to more than 2200 during the
explosion. The network includes, at any given time, all relevant isotopes from
hydrogen through polonium (Z=84). Even the limited grid of stellar masses
studied suggests that overall good agreement can be achieved with the solar
abundances of nuclei between 16O and 90Zr. Interesting discrepancies are seen
in the 20 M_sun model and, so far, only in that model, that are a consequence
of the merging of the oxygen, neon, and carbon shells about a day prior to core
collapse. We find that, in some stars, most of the ``p-process'' nuclei can be
produced in the convective oxygen burning shell moments prior to collapse; in
others, they are made only in the explosion. Serious deficiencies still exist
in all cases for the p-process isotopes of Ru and Mo.Comment: 53 pages, 17 color figures (3 as separate GIF images), slightly
extended discussion and references, accepted by Ap
IAC-Star: a Code for Synthetic Color-Magnitude Diagram Computation
The code IAC-star is presented. It generates synthetic HR and color-magnitude
diagrams (CMDs) and is mainly aimed to star formation history studies in nearby
galaxies. Composite stellar populations are calculated on a star by star basis,
by computing the luminosity, effective temperature and gravity of each star by
direct bi-logarithmic interpolation in the metallicity and age grid of a
library of stellar evolution tracks. Visual (broad band and HST) and infrared
magnitudes are also provided for each star after applying bolometric
corrections. The Padua (Bertelli et al. 1994, Girardi et al. 2000) and Teramo
(Pietrinferni et al. 2004) stellar evolution libraries and various bolometric
corrections libraries are used in the current version. A variety of star
formation rate functions, initial mass functions and chemical enrichment laws
are allowed and binary stars can be computed. Although the main motivation of
the code is the computation of synthetic CMDs, it also provides integrated
masses, luminosities and magnitudes as well as surface brightness fluctuation
luminosities and magnitudes for the total synthetic stellar population, and
therefore it can also be used for population synthesis research. The code is
offered for free use and can be executed at the site {\tt
http://iac-star.iac.es}, with the only requirement of referencing this paper
and crediting as indicated in the site.Comment: Astronomical Journal, in pres
Description of the Scenario Machine
We present here an updated description of the "Scenario Machine" code. This
tool is used to carry out a population synthesis of binary stars. Previous
version of the description can be found at
http://xray.sai.msu.ru/~mystery//articles/review/contents.htmlComment: 32 pages, 3 figures. Corrected typo
Reaction Rates Uncertainties and the Production of F19 in AGB Stars
We present nucleosynthesis calculations and the resulting 19F stellar yields
for a large set of models with different masses and metallicity. We find that
the production of fluorine depends on the temperature of the convective pulses,
the amount of primary 12C mixed into the envelope by third dredge up and the
extent of the partial mixing zone. Then we perform a detailed analysis of the
reaction rates involved in the production of 19F and the effects of their
uncertainties. We find that the major uncertainties are associated with the
14C(alpha,gamma)18O and the 19F(alpha,p)22Ne reaction rates. For these two
reactions we present new estimates of the rates and their uncertainties. The
importance of the partial mixing zone is reduced when using our estimate for
the 14C(alpha,gamma)18O rate. Taking into account both the uncertainties
related to the partial mixing zone and those related to nuclear reactions, the
highest values of 19F enhancements observed in AGB stars are not matched by the
models. This is a problem that will have to be revised by providing a better
understanding of the formation and nucleosynthesis in the partial mixing zone,
also in relation to reducing the uncertainties of the 14C(alpha,gamma)18O
reaction rate. At the same time the possible effect of Cool Bottom Processing
at the base of the convective envelope should be included in the computation of
AGB nucleosynthesis. This process could in principle help matching the highest
19F abundances observed by decreasing the C/O ratio at the surface of the star,
while leaving the 19F abundance unchanged.Comment: 40 pages, 8 figures, accepted for publication on the Astrophysical
Journa
Therapeutic opportunities within the DNA damage response
The DNA damage response (DDR) is essential for maintaining the genomic integrity of the cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have been exploited therapeutically in the treatment of cancer with radiation therapies or genotoxic chemotherapies. More recently, protein components of the DDR systems have been identified as promising avenues for targeted cancer therapeutics. Here, we present an in-depth analysis of the function, role in cancer and therapeutic potential of 450 expert-curated human DDR genes. We discuss the DDR drugs that have been approved by the US Food and Drug Administration (FDA) or that are under clinical investigation. We examine large-scale genomic and expression data for 15 cancers to identify deregulated components of the DDR, and we apply systematic computational analysis to identify DDR proteins that are amenable to modulation by small molecules, highlighting potential novel therapeutic targets
Re-examination of the Controversial Coexistence of Traumatic Brain Injury and Posttraumatic Stress Disorder: Misdiagnosis and Self-Report Measures
The coexistence of traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) remains a controversial issue in the literature. To address this controversy, we focused primarily on the civilian-related literature of TBI and PTSD. Some investigators have argued that individuals who had been rendered unconscious or suffered amnesia due to a TBI are unable to develop PTSD because they would be unable to consciously experience the symptoms of fear, helplessness, and horror associated with the development of PTSD. Other investigators have reported that individuals who sustain TBI, regardless of its severity, can develop PTSD even in the context of prolonged unconsciousness. A careful review of the methodologies employed in these studies reveals that investigators who relied on clinical interviews of TBI patients to diagnose PTSD found little or no evidence of PTSD. In contrast, investigators who relied on PTSD questionnaires to diagnose PTSD found considerable evidence of PTSD. Further analysis revealed that many of the TBI patients who were initially diagnosed with PTSD according to self-report questionnaires did not meet the diagnostic criteria for PTSD upon completion of a clinical interview. In particular, patients with severe TBI were often misdiagnosed with PTSD. A number of investigators found that many of the severe TBI patients failed to follow the questionnaire instructions and erroneously endorsed PTSD symptoms because of their cognitive difficulties. Because PTSD questionnaires are not designed to discriminate between PTSD and TBI symptoms or determine whether a patient's responses are accurate or exaggerated, studies that rely on self-report questionnaires to evaluate PTSD in TBI patients are at risk of misdiagnosing PTSD. Further research should evaluate the degree to which misdiagnosis of PTSD occurs in individuals who have sustained mild TBI
Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury
BACKGROUND: The ubiquitin-proteasome-system (UPS) is the major intracellular pathway leading to the degradation of unwanted and/or misfolded soluble proteins. This includes proteins regulating cellular survival, synaptic plasticity and neurotransmitter signaling; processes controlling excitability thresholds that are altered by epileptogenic insults. Dysfunction of the UPS has been reported to occur in a brain region- and cell-specific manner and contribute to disease progression in acute and chronic brain diseases. Prolonged seizures, status epilepticus, may alter UPS function but there has been no systematic attempt to map when and where this occurs in vivo or to determine the consequences of proteasome inhibition on seizure-induced brain injury.
METHOD: To determine whether seizures lead to an impairment of the UPS, we used a mouse model of status epilepticus whereby seizures are triggered by an intra-amygdala injection of kainic acid. Status epilepticus in this model causes cell death in selected brain areas, in particular the ipsilateral CA3 subfield of the hippocampus, and the development of epilepsy after a short latent period. To monitor seizure-induced dysfunction of the UPS we used a UPS inhibition reporter mouse expressing the ubiquitin fusion degradation substrate ubiquitin(G76V)-green fluorescent protein. Treatment with the specific proteasome inhibitor epoxomicin was used to establish the impact of proteasome inhibition on seizure-induced pathology.
RESULTS AND CONCLUSIONS: Our studies show that status epilepticus induced by intra-amygdala kainic acid causes select spatio-temporal UPS inhibition which is most evident in damage-resistant regions of the hippocampus, including CA1 pyramidal and dentate granule neurons then appears later in astrocytes. In support of this exerting a beneficial effect, injection of mice with the proteasome inhibitor epoxomicin protected the normally vulnerable hippocampal CA3 subfield from seizure-induced neuronal death in the model. These studies reveal brain region- and cell-specific UPS impairment occurs after seizures and suggest UPS inhibition can protect against seizure-induced brain damage. Identifying networks or pathways regulated through the proteasome after seizures may yield novel target genes for the treatment of seizure-induced cell death and possibly epilepsy
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