Kontrastmittelinduzierte Neurotoxizität - DE_Vigilance-News-Edition_29_2022

Die Kontrastmittel-induzierte Neurotoxizität ist eine seltene, akute und meist reversible Komplikation von Kontrastmitteln in bildgebenden Verfahren, welche aufgrund ihrer Symptomatik oft einem Schlaganfall ähneln kann. Dieser Fallbericht handelt von einer 77-jährigen Patientin, bei welcher während einer Koronarangiographie mit dem Kontrastmittel Ultravist® (Iopromid) eine Aphasie und Hemiparese auftrat. Zunächst bestand der Verdacht auf einen zerebrovaskulären Insult, im Verlauf wurden die Beschwerden jedoch als eine Kontrastmittel-induzierte Enzephalopathie interpretiert

Effects of corn supplementation on serum and muscle microRNA profiles in horses

Laminitis associated with equine metabolic syndrome causes significant economic losses in the equine industry. Diets high in non-structural carbohydrates (NSC) have been linked to insulin resistance and laminitis in horses. Nutrigenomic studies analyzing the interaction of diets high in NSCs and gene expression regulating endogenous microRNAs (miRNA) are rare. This study\u27s objectives were to determine whether miRNAs from dietary corn can be detected in equine serum and muscle and its impacts on endogenous miRNA. Twelve mares were blocked by age, body condition score, and weight and assigned to a control (mixed legume grass hay diet) and a mixed legume hay diet supplemented with corn. Muscle biopsies and serum were collected on Days 0 and 28. Transcript abundances were analyzed using qRT-PCR for three plant-specific and 277 endogenous equine miRNAs. Plant miRNAs were found in serum and skeletal muscle samples with a treatment effect (p \u3c .05) with corn-specific miRNA being higher than control in serum after feeding. Endogenous miRNAs showed 12 different (p \u3c .05) miRNAs in equine serum after corn supplementation, six (eca-mir16, -4863p, -4865p, -126- 3p, -296, and -192) previously linked to obesity or metabolic disease. The results of our study indicate that dietary plant miRNAs can appear in circulation and tissues and may regulate endogenous genes

Effects of corn supplementation on serum and muscle microRNA profiles in horses

Abstract Laminitis associated with equine metabolic syndrome causes significant economic losses in the equine industry. Diets high in non‐structural carbohydrates (NSC) have been linked to insulin resistance and laminitis in horses. Nutrigenomic studies analyzing the interaction of diets high in NSCs and gene expression regulating endogenous microRNAs (miRNA) are rare. This study's objectives were to determine whether miRNAs from dietary corn can be detected in equine serum and muscle and its impacts on endogenous miRNA. Twelve mares were blocked by age, body condition score, and weight and assigned to a control (mixed legume grass hay diet) and a mixed legume hay diet supplemented with corn. Muscle biopsies and serum were collected on Days 0 and 28. Transcript abundances were analyzed using qRT‐PCR for three plant‐specific and 277 endogenous equine miRNAs. Plant miRNAs were found in serum and skeletal muscle samples with a treatment effect (p < .05) with corn‐specific miRNA being higher than control in serum after feeding. Endogenous miRNAs showed 12 different (p < .05) miRNAs in equine serum after corn supplementation, six (eca‐mir16, ‐4863p, ‐4865p, ‐126‐3p, ‐296, and ‐192) previously linked to obesity or metabolic disease. The results of our study indicate that dietary plant miRNAs can appear in circulation and tissues and may regulate endogenous genes