Infrared Spectroscopy of a Massive Obscured Star Cluster in the Antennae Galaxies (NGC 4038/4039) with NIRSPEC

We present infrared spectroscopy of the Antennae Galaxies (NGC 4038/4039) with NIRSPEC at the W. M. Keck Observatory. We imaged the star clusters in the vicinity of the southern nucleus (NGC 4039) in 0.39" seeing in K-band using NIRSPEC's slit-viewing camera. The brightest star cluster revealed in the near-IR (M_K(0) = -17.9) is insignificant optically, but coincident with the highest surface brightness peak in the mid-IR (12-18 micron) ISO image presented by Mirabel et al. (1998). We obtained high signal-to-noise 2.03 - 2.45 micron spectra of the nucleus and the obscured star cluster at R ~ 1900. The cluster is very young (4 Myr old), massive (16e6 M_sun), and compact (density ~ 115 M_sun pc^(-3) within a 32 pc half-light radius), assuming a Salpeter IMF (0.1 - 100 M_sun). Its hot stars have a radiation field characterized by T_eff ~ 39,000 K, and they ionize a compact H II region with n_e ~ 1e4 cm^(-3). The stars are deeply embedded in gas and dust (A_V ~ 9-10 mag), and their strong FUV field powers a clumpy photodissociation region with densities n_H >= 1e5 cm^(-3) on scales of up to 200 pc, radiating L[H_2 1-0 S(1)] = 9600 L_sun.Comment: 4 pages, 5 embedded figures. To appear in proceedings of 33d ESLAB Symposium: Star Formation from the Small to the Large Scale, held in Noordwijk, The Netherlands, Nov. 1999. Also available at http://astro.berkeley.edu/~agilber

Does network complexity help organize Babel's library?

In this work, we study properties of texts from the perspective of complex network theory. Words in given texts are linked by co-occurrence and transformed into networks, and we observe that these display topological properties common to other complex systems. However, there are some properties that seem to be exclusive to texts; many of these properties depend on the frequency of words in the text, while others seem to be strictly determined by the grammar. Precisely, these properties allow for a categorization of texts as either with a sense and others encoded or senseless

Observation and Modeling of the Solar Transition Region: II. Solutions of the Quasi-Static Loop Model

In the present work we undertake a study of the quasi-static loop model and the observational consequences of the various solutions found. We obtain the most general solutions consistent with certain initial conditions. Great care is exercised in choosing these conditions to be physically plausible (motivated by observations). We show that the assumptions of previous quasi-static loop models, such as the models of Rosner, Tucker and Vaiana (1978) and Veseckey, Antiochos and Underwood (1979), are not necessarily valid for small loops at transition region temperatures. We find three general classes of solutions for the quasi-static loop model, which we denote, radiation dominated loops, conduction dominated loops and classical loops. These solutions are then compared with observations. Departures from the classical scaling law of RTV are found for the solutions obtained. It is shown that loops of the type that we model here can make a significant contribution to lower transition region emission via thermal conduction from the upper transition region.Comment: 30 pages, 3 figures, Submitted to ApJ, Microsoft Word File 6.0/9

The DIAD Approach to Correlative Synchrotron X‑ray Imaging and Diffraction Analysis of Human Enamel

The Dual Imaging and Diffraction (DIAD) beamline at Diamond Light Source (Didcot, U.K.) implements a correlative approach to the dynamic study of materials based on concurrent analysis of identical sample locations using complementary X-ray modalities to reveal structural detail at various length scales. Namely, the underlying beamline principle and its practical implementation allow the collocation of chosen regions within the sample and their interrogation using real-space imaging (radiography and tomography) and reciprocal space scattering (diffraction). The switching between the two principal modes is made smooth and rapid by design, so that the data collected is interlaced to obtain near-simultaneous multimodal characterization. Different specific photon energies are used for each mode, and the interlacing of acquisition steps allows conducting static and dynamic experiments. Building on the demonstrated realization of this state-of-the-art approach requires further refining of the experimental practice, namely, the methods for gauge volume collocation under different modes of beam–sample interaction. To address this challenge, experiments were conducted at DIAD devoted to the study of human dental enamel, a hierarchical structure composed of hydroxyapatite mineral nanocrystals, as a static sample previously affected by dental caries (tooth decay) as well as under dynamic conditions simulating the process of acid demineralization. Collocation and correlation were achieved between WAXS (wide-angle X-ray scattering), 2D (radiographic), and 3D (tomographic) imaging. While X-ray imaging in 2D or 3D modes reveals real-space details of the sample microstructure, X-ray scattering data for each gauge volume provided statistical nanoscale and ultrastructural polycrystal reciprocal-space information such as phase and preferred orientation (texture). Careful registration of the gauge volume positions recorded during the scans allowed direct covisualization of the data from two modalities. Diffraction gauge volumes were identified and visualized within the tomographic data sets, revealing the underlying local information to support the interpretation of the diffraction patterns. The present implementation of the 4D microscopy paradigm allowed following the progression of demineralization and its correlation with time-dependent WAXS pattern evolution in an approach that is transferable to other material systems

2D-DIGE analysis of ovarian cancer cell responses to cytotoxic gold compounds

Cytotoxic gold compounds hold today great promise as new pharmacological agents for treatment of human ovarian carcinoma; yet, their mode of action is still largely unknown. To shed light on the underlying molecular mechanisms, we performed 2D-DIGE analysis to identify differential protein expression in a cisplatin-sensitive human ovarian cancer cell line (A2780/S) following treatment with two representative gold(III) complexes that are known to be potent antiproliferative agents, namely AuL12 and Au2Phen. Software analysis using DeCyder was performed and few differentially expressed protein spots were visualized between the three examined settings after 24h exposure to the cytotoxic compounds, implying that cellular damage at least during the early phases of exposure is quite limited and selective reflecting the attempts of the cell to repair damage and to survive the insult. The potential of novel proteomic methods to disclose mechanistic details of cytotoxic metallodrugs is herein further highlighted. Different patterns of proteomic changes were highlighted for the two metallodrugs with only a few perturbed protein spots in common. Using MALDI-TOF MS and ESI-Ion trap MS/MS, several differentially expressed proteins were identified. Two of these were validated by western blotting: Ubiquilin-1, responsible for inhibiting degradation of protein such as p53 and NAP1L1, a candidate marker identified in primary tumors. In conclusion, we performed a comprehensive analysis of proteins regulated by AuL12 and Au2Phen, providing a useful insight into their mechanisms of action

Solar Wind and its Evolution

By using our previous results of magnetohydrodynamical simulations for the solar wind from open flux tubes, I discuss how the solar wind in the past is different from the current solar wind. The simulations are performed in fixed one-dimensional super-radially open magnetic flux tubes by inputing various types of fluctuations from the photosphere, which automatically determines solar wind properties in a forward manner. The three important parameters which determine physical properties of the solar wind are surface fluctuation, magnetic field strengths, and the configuration of magnetic flux tubes. Adjusting these parameters to the sun at earlier times in a qualitative sense, I infer that the quasi-steady-state component of the solar wind in the past was denser and slightly slower if the effect of the magneto-centrifugal force is not significant. I also discuss effects of magneto-centrifugal force and roles of coronal mass ejections.Comment: 6 pages, 1 figure, Earth, Planets, & Space in press (based on 5th Alfven Conference) correction of discussion on a related pape