Profits, Prestige, and a Little Bit of Sunshine: American Independent Cinema Enters the Mainstream

This thesis investigates the recent developments that have occurred in the independent film market after the major Hollywood studios created their own specialty divisions to produce and distribute independent films. Due to the involvement of the major studios, independent films became more mainstream while their various costs were also driven up due to the increased amount of independent films that were released by the studios. The financial crisis of 2008 forced the major studios to contract their production of independent films and this contraction allowed the prices of independent films to return to more stable levels

Inhomogeneous Magnetoelectric Effect on Defect in Multiferroic Material: Symmetry Prediction

Inhomogeneous magnetoelectric effect in magnetization distribution heterogeneities (0-degree domain walls) appeared on crystal lattice defect of the multiferroic material has been investigated. Magnetic symmetry based predictions of kind of electrical polarization distribution in their volumes were used. It was found that magnetization distribution heterogeneity with any symmetry produces electrical polarization. Results were systemized in scope of micromagnetic structure chirality. It was shown that all 0-degree domain walls with time-noninvariant chirality have identical type of spatial distribution of the magnetization and polarization.Comment: submitted to IOP Conference Series: Materials Science and Engineerin

Can statin preventative treatment inform geroscience-guided therapeutics?

: Potential senotherapeutic effect of statins may lead to prevention and reduction of frailty

Informal animation sketching: Requirements and design

We present an interface design for creating informal animations from sketches. Current tools for creating animation are extremely complex. This makes it difficult for designers to prototype animations and nearly impossible for novices to create them at all. Simple animation systems exist but severely restrict the types of motion that can be represented. To guide our design of an animation sketching interface, we conducted field studies into the needs of professional and novice animators. These studies show the wide variety of motions that users desire in informal animations and indicate how to prioritize these types of motion. The interface described here allows the most important types of motion to be defined with pen gestures, and gives visual feedback for coordination of events

VACUTAINER(® )CPT™ and Ficoll density gradient separation perform equivalently in maintaining the quality and function of PBMC from HIV seropositive blood samples

BACKGROUND: For immune monitoring studies during HIV vaccine clinical trials, whole blood specimens from HIV seropositive (HIV(+)) patients may be collected at multiple sites and sent to a central location for peripheral blood mononuclear cell (PBMC) isolation, cryopreservation and functional evaluation. In this study we show a comparison of two PBMC preparation options, Ficoll density gradient separation (Ficoll) and Cell Preparation Tubes (CPT) using shipped whole blood specimens from 19 HIV(+ )patients (CD4 > 350, viral load < 50). The pre- and post- cryopreservation performance of samples collected by these two methods were compared by assessment of antigen-specific IFNγ expression in CD8(+ )and CD8(- )T cells, cellular viability, and cellular recovery. RESULTS: The results indicate that cryopreserved PBMC samples tested for CMV- and HIV- specific interferon-gamma (IFNγ) expression performed equivalent to the respective fresh PBMC processed under both collection conditions. Compared to fresh PBMC, the viability was significantly lower for cryopreserved PBMC derived using Ficoll, although it was never less than 90%. There were no significant differences in the IFNγ response, viability, or recovery between cryopreserved PBMC derived by Ficoll and by CPT. CONCLUSION: These data suggest that CPT is an efficient system for the collection and cryopreservation of functionally active HIV(+ )PBMC, as well as a viable alternative to Ficoll gradient separation

The information analysis center concept as developed by the Radiation Shielding Information Center in its computer codes activities

Information analysis center concept and computer codes for calculating radiation transport, and shield design