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The Expanding Landscape of Alternative Splicing Variation in Human Populations.
Alternative splicing is a tightly regulated biological process by which the number of gene products for any given gene can be greatly expanded. Genomic variants in splicing regulatory sequences can disrupt splicing and cause disease. Recent developments in sequencing technologies and computational biology have allowed researchers to investigate alternative splicing at an unprecedented scale and resolution. Population-scale transcriptome studies have revealed many naturally occurring genetic variants that modulate alternative splicing and consequently influence phenotypic variability and disease susceptibility in human populations. Innovations in experimental and computational tools such as massively parallel reporter assays and deep learning have enabled the rapid screening of genomic variants for their causal impacts on splicing. In this review, we describe technological advances that have greatly increased the speed and scale at which discoveries are made about the genetic variation of alternative splicing. We summarize major findings from population transcriptomic studies of alternative splicing and discuss the implications of these findings for human genetics and medicine
Quark number scaling of hadronic spectra and constituent quark degree of freedom in -Pb collisions at TeV
We show that the experimental data of spectra of identified hadrons
released recently by ALICE collaboration for -Pb collisions at
TeV exhibit a distinct universal behavior --- the quark
number scaling. We further show that the scaling is a direct consequence of
quark (re-)combination mechanism of hadronization and can be regarded as a
strong indication of the existence of the underlying source with constituent
quark degree of freedom for the production of hadrons in -Pb collisions at
such high energies. We make also predictions for production of other hadrons.Comment: 5 pages, 3 figure
Human Pose Estimation using Global and Local Normalization
In this paper, we address the problem of estimating the positions of human
joints, i.e., articulated pose estimation. Recent state-of-the-art solutions
model two key issues, joint detection and spatial configuration refinement,
together using convolutional neural networks. Our work mainly focuses on
spatial configuration refinement by reducing variations of human poses
statistically, which is motivated by the observation that the scattered
distribution of the relative locations of joints e.g., the left wrist is
distributed nearly uniformly in a circular area around the left shoulder) makes
the learning of convolutional spatial models hard. We present a two-stage
normalization scheme, human body normalization and limb normalization, to make
the distribution of the relative joint locations compact, resulting in easier
learning of convolutional spatial models and more accurate pose estimation. In
addition, our empirical results show that incorporating multi-scale supervision
and multi-scale fusion into the joint detection network is beneficial.
Experiment results demonstrate that our method consistently outperforms
state-of-the-art methods on the benchmarks.Comment: ICCV201
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