Review of Conformally Flat Approximation for Binary Neutron Star Initial Conditions

The spatially conformally flat approximation (CFA) is a viable method to deduce initial conditions for the subsequent evolution of binary neutron stars employing the full Einstein equations. Here we review the status of the original formulation of the CFA for the general relativistic hydrodynamic initial conditions of binary neutron stars. We illustrate the stability of the conformally flat condition on the hydrodynamics by numerically evolving ~100 quasi-circular orbits. We illustrate the use of this approximation for orbiting neutron stars in the quasi-circular orbit approximation to demonstrate the equation of state dependence of these initial conditions and how they might affect the emergent gravitational wave frequency as the stars approach the innermost stable circular orbit.Comment: 22 pages, 12 figures, revised as per referee recommendation

Self-interacting dark matter and Higgs bosons in the SU(3)_C x SU(3)_L x U(1)_N model with right-handed neutrinos

We investigate the possibility that dark matter could be made from CP-even and CP- odd Higgs bosons in the SU(3)_C X SU(3)_L X U(1)_N (3-3-1) model with right-handed neutrinos. This self-interacting dark matters are stable without imposing of new symmetry and should be weak-interacting.Comment: 7 pages, Latex, To appear in Europhys. Let

White blood cell count and risk of incident lung cancer in the UK Biobank

Background The contribution of measurable immunological/inflammatory parameters to lung cancer development remains unclear, particularly among never-smokers. We investigated the relationship between total and differential white blood cell (WBC) counts and incident lung cancer risk overall and among subgroups defined by smoking status and sex in the United Kingdom (UK). Methods We evaluated 424,407 adults aged 37-73 years from the UK Biobank. Questionnaires, physical measurements, and blood were administered/collected at baseline in 2006-2010. Complete blood cell counts were measured using standard methods. Lung cancer diagnoses and histological classifications were obtained from cancer registries. Multivariable Cox regression models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of incident lung cancer in relation to quartiles (Q) of total WBC and subtype-specific counts, with Q1 as the reference. Results There were 1,493 incident cases diagnosed over an average 7-year follow-up. Overall, the highest quartile of total WBC count was significantly associated with elevated lung cancer risk (HRQ4=1.67, 95% CI:1.41-1.98). Among women, increased risks were found in current-smokers (ncases/n=244/19,464, HRQ4=2.15, 95% CI:1.46-3.16), former-smokers (ncases/n=280/69,198, HRQ4=1.75, 95% CI:1.24-2.47), and never-smokers without environmental tobacco smoke exposure (ncases/n=108/111,294, HRQ4=1.93, 95% CI:1.11-3.35). Among men, stronger associations were identified in current-smokers (ncases/n=329/22,934, HRQ4=2.95, 95% CI:2.04-4.26) and former-smokers (ncases/n= 358/71,616, HRQ4=2.38, 95% CI:1.74-3.27) but not in never-smokers. Findings were similar for lung adenocarcinoma and squamous cell carcinoma and were driven primarily by elevated neutrophil fractions. Conclusions Elevated WBCs could potentially be one of many important markers for increased lung cancer risk, especially among never-smoking women and ever-smoking men

Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers.

Benzene exposure causes acute myeloid leukemia and hematotoxicity, shown as suppression of mature blood and myeloid progenitor cell numbers. As the leukemia-related aneuploidies monosomy 7 and trisomy 8 previously had been detected in the mature peripheral blood cells of exposed workers, we hypothesized that benzene could cause leukemia through the induction of these aneuploidies in hematopoietic stem and progenitor cells. We measured loss and gain of chromosomes 7 and 8 by fluorescence in situ hybridization in interphase colony-forming unit-granulocyte-macrophage (CFU-GM) cells cultured from otherwise healthy benzene-exposed (n=28) and unexposed (n=14) workers. CFU-GM monosomy 7 and 8 levels (but not trisomy) were significantly increased in subjects exposed to benzene overall, compared with levels in the control subjects (P=0.0055 and P=0.0034, respectively). Levels of monosomy 7 and 8 were significantly increased in subjects exposed to <10 p.p.m. (20%, P=0.0419 and 28%, P=0.0056, respectively) and ≥ 10 p.p.m. (48%, P=0.0045 and 32%, 0.0354) benzene, compared with controls, and significant exposure-response trends were detected (P(trend)=0.0033 and 0.0057). These data show that monosomies 7 and 8 are produced in a dose-dependent manner in the blood progenitor cells of workers exposed to benzene, and may be mechanistically relevant biomarkers of early effect for benzene and other leukemogens

Late Decaying Dark Matter, Bulk Viscosity and the Cosmic Acceleration

We discuss a cosmology in which cold dark matter begins to decay into relativistic particles at a recent epoch (z < 1). We show that the large entropy production and associated bulk viscosity from such decays leads to an accelerating cosmology as required by observations. We investigate the effects of decaying cold dark matter in a Lambda = 0, flat, initially matter dominated cosmology. We show that this model satisfies the cosmological constraint from the redshift-distance relation for type Ia supernovae. The age in such models is also consistent with the constraints from the oldest stars and globular clusters. Possible candidates for this late decaying dark matter are suggested along with additional observational tests of this cosmological paradigm.Comment: 8 pages, 3 figures, 1 tabl