MOVEMENT VARIABILITY IN THE SPINAL KINEMATICS OF FAST BOWLERS

The purpose of this study was to quantify the inter- and intra-individual spinal movement variability in a group of pre-elite and elite fast bowlers. Eleven pre-elite and elite level bowlers from the Otago region (New Zealand) took part in the study. Each bowler bowled two six-over spells, while being recorded by a 3D motion analysis system in two sessions, one week apart. Thorax and lumbopelvis segments were modelled and analysed. Between session changes in spine kinematics were greatest for lateral bending (p = .0001). Inter-individual variability was much greater than the average within-participant variability (more than double), highlighting the need for individual analyses of fast bowlers in the future. Inter- and intra-individual variability in spinal movement among a homogenous group of fast bowlers found in the current study will be important for designing future studies on cricket fast bowlers

Leakage Current Mechanisms in SiGe HBTs Fabricated Using Selective and Nonselective Epitaxy

SiGe heterojunction bipolar transistors (HTBs) have been fabricated using selective epitaxy for the Si collector, followed in the same growth step by nonselective epitaxy for the p+ SiGe base and n-Si emitter cap. DC electrical characteristics are compared with cross-section TEM images to identify the mechanisms and origins of leakage currents associated with the epitaxy in two different types of transistor . In the first type, the polysilicon emitter is smaller than the collector active area, so that the extrinsic base implant penetrates into the single-crystal Si and SiGe around the perimeter of the emitter and the polycrystalline Si and SiGe exrtrinsic base. In these transistors, the Bummel plots are near-ideal and there is no evidence of emitter/collector leakage. In the second type, the collector active area is smaller than the polysilicon emitter, so the extrinsic base implant only penetrates into the polysilicon extrinsic base. In these transistors, the leakage currents observed depend on the base doping level. In transistors with a low doped base, emitter/collector and emitter/base leakage is observed, whereas in transistors with a high doped base only emitter/base leakage is observed. The emitter/collector leakage is explained by punch through o fhte base caused by thinning of the SiGe base at the emitter perimeter. The emitter/base leakeage is shown to be due to Poole-Frenkel mechanism and is explained by penetration of the emitter/base depletion region into the p+ polysilicon extrinsic base at the emitter periphery. Variable collector/base reverse leakage currents are observed and a variety of mechanisms are observed, including Shockley-Read-Hall recombination, trap assisted tunneling, Poole Frenkel and band to band tunneling. These result s are explained by the presence of polysilicon grains on the sidewalls of the field oxide at the collector perimeter

Dataset for 'A highly active mineral-based ice nucleating agent supports in situ cell cryopreservation in a high throughput format'

Cryopreservation of biological matter in microlitre scale volumes of liquid would be useful for a range of applications. At present, it is challenging because small volumes of water tend to supercool, and deep supercooling is known to lead to poor post thaw cell viability. Here we show that a mineral ice nucleator can almost eliminate supercooling in 100 microlitre liquid volumes during cryopreservation. This strategy of eliminating supercooling greatly enhances cell viability relative to cryopreservation protocols with uncontrolled ice nucleation. Using infrared thermography, we demonstrate a direct relationship between extent of supercooling and post-thaw cell viability. Using a mineral nucleator delivery system we open the door to the routine cryopreservation of mammalian cells in multiwell plates for applications such as high throughput toxicology testing of pharmaceutical products and regenerative medicine

No Evidence for Disease History as a Risk Factor for Narcolepsy after A(H1N1)pdm09 Vaccination

OBJECTIVES: To investigate disease history before A(H1N1)pdm09 vaccination as a risk factor for narcolepsy.METHODS: Case-control study in Sweden. Cases included persons referred for a Multiple Sleep Latency Test between 2009 and 2010, identified through diagnostic sleep centres and confirmed through independent review of medical charts. Controls, selected from the total population register, were matched to cases on age, gender, MSLT-referral date and county of residence. Disease history (prescriptions and diagnoses) and vaccination history was collected through telephone interviews and population-based healthcare registers. Conditional logistic regression was used to investigate disease history before A(H1N1)pdm09 vaccination as a risk-factor for narcolepsy.RESULTS: In total, 72 narcolepsy cases and 251 controls were included (range 3-69 years mean19-years). Risk of narcolepsy was increased in individuals with a disease history of nervous system disorders (OR range = 3.6-8.8) and mental and behavioural disorders (OR = 3.8, 95% CI 1.6-8.8) before referral. In a second analysis of vaccinated individuals only, nearly all initial associations were no longer statistically significant and effect sizes were smaller (OR range = 1.3-2.6). A significant effect for antibiotics (OR = 0.4, 95% CI 0.2-0.8) and a marginally significant effect for nervous system disorders was observed. In a third case-only analysis, comparing cases referred before vaccination to those referred after; prescriptions for nervous system disorders (OR = 26.0 95% CI 4.0-170.2) and ADHD (OR = 35.3 95% CI 3.4-369.9) were statistically significant during the vaccination period, suggesting initial associations were due to confounding by indication.CONCLUSION: The findings of this study do not support disease history before A(H1N1)pdm09 vaccination as a risk factor for narcolepsy

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

Insulin-like growth factors elicit many responses through activation of phosphoinositide 3-OH kinase (PI3K). The tuberous sclerosis complex (TSC1-2) suppresses cell growth by negatively regulating a protein kinase, p70S6K (S6K1), which generally requires PI3K signals for its activation. Here, we show that TSC1-2 is required for insulin signaling to PI3K. TSC1-2 maintains insulin signaling to PI3K by restraining the activity of S6K, which when activated inactivates insulin receptor substrate (IRS) function, via repression of IRS-1 gene expression and via direct phosphorylation of IRS-1. Our results argue that the low malignant potential of tumors arising from TSC1-2 dysfunction may be explained by the failure of TSC mutant cells to activate PI3K and its downstream effectors

The Dipole Coupling of Atoms and Light in Gravitational Fields

The dipole coupling term between a system of N particles with total charge zero and the electromagnetic field is derived in the presence of a weak gravitational field. It is shown that the form of the coupling remains the same as in flat space-time if it is written with respect to the proper time of the observer and to the measurable field components. Some remarks concerning the connection between the minimal and the dipole coupling are given.Comment: 10 pages, LaTe

A New Giant Stellar Structure in the Outer Halo of M31

The Sloan Digital Sky Survey has revealed an overdensity of luminous red giant stars ~ 3 degrees (40 projected kpc) to the northeast of M31, which we have called Andromeda NE. The line-of-sight distance to Andromeda NE is within approximately 50 kpc of M31; Andromeda NE is not a physically unrelated projection. Andromeda NE has a g-band absolute magnitude of ~ -11.6 and central surface brightness of ~ 29 mag/sq.arcsec, making it nearly two orders of magnitude more diffuse than any known Local Group dwarf galaxy at that luminosity. Based on its distance and morphology, Andromeda NE is likely undergoing tidal disruption. Andromeda NE's red giant branch color is unlike that of M31's present-day outer disk or the stellar stream reported by Ibata et al. (2001), arguing against a direct link between Andromeda NE and these structures. However, Andromeda NE has a red giant branch color similar to that of the G1 clump; it is possible that these structures are both material torn off of M31's disk in the distant past, or that these are both part of one ancient stellar stream.Comment: 11 pages, 3 figures; ApJ Letters accepted versio