Validation of the International Prostate Symptoms Score in Chinese males and females with lower urinary tract symptoms

Objectives To evaluate the translation of the IPSS (Hong Kong Chinese version 1) and to assess the applicability, validity, reliability and sensitivity of the instrument in both males and females with LUTS in Chinese population. Methods The translation of the IPSS (Hong Kong Chinese version 1) was reviewed through back translation. Modifications were made, resulting in the development of The IPSS (Hong Kong Chinese version 2). The content validity was assessed by contend validity index. 233 subjects with LUTS were recruited in Hong Kong primary care settings for pilot psychometric testing. The construct validity was assessed by corrected item-total correlation and Pearson’s correlation test against ICIQ-UI SF, IIQ-7 and SF-12 v2. The reliability was assessed by the internal consistency (Cronbach’s Alpha coefficient) and test –retest reliability (Intraclass correlation coefficient). The Sensitivity was determined by performing known group comparisons by independent T-test. Results The content validity index for all items could reach 1. Corrected item-total correlation scores were ≥0.4 for four symptom questions (feeling of incomplete bladder emptying, intermittency, weak stream and straining). Overall, the total symptom score moderately correlated with ICIQ-UI SF. The quality of life score moderately correlated with the IIQ-7 but weakly correlated with SF-12 v2. Overall, the reliability of the IPSS (Hong Kong Chinese version 2) was acceptable (Cronbach’s Alpha coefficient = 0.71, ICC of the symptom questions =0.8, ICC of the quality of life question =0.7). The symptoms questions and quality of life questions of the IPSS (Hong Kong Chinese versions 2) were sensitive in detecting differences between groups. Conclusions The IPSS (Hong Kong Chinese version 2) is a valid, reliable and sensitive measure to assess Chinese females and males with lower urinary tract symptoms. The IPSS quality of life question is more sensitive than the generic quality of life measure to differentiate subgroups.published_or_final_versio

Evaluation of the internal and external responsiveness of the Pressure Ulcer Scale for Healing (PUSH) tool for assessing acute and chronic wounds

published_or_final_versio

Genetic alteration and gene expression modulation during cancer progression

Cancer progresses through a series of histopathological stages. Progression is thought to be driven by the accumulation of genetic alterations and consequently gene expression pattern changes. The identification of genes and pathways involved will not only enhance our understanding of the biology of this process, it will also provide new targets for early diagnosis and facilitate treatment design. Genomic approaches have proven to be effective in detecting chromosomal alterations and identifying genes disrupted in cancer. Gene expression profiling has led to the subclassification of tumors. In this article, we will describe the current technologies used in cancer gene discovery, the model systems used to validate the significance of the genes and pathways, and some of the genes and pathways implicated in the progression of preneoplastic and early stage cancer

Water compatible resin for separation and recovery of dissolved precious metals

Trace Contaminants in Water: Genesis, Rapid Detection and Sustainable Removal Processes: abstract no. 353fOpen URL - http://apps.aiche.org/proceedings/Abstract.aspx?PaperID=119742The value of precious metals such as gold to be recovered in the industrial effluents within Pearl River Delta area is over HK$20 million per annual. Furthermore, with the expected tightening of environmental legislation and enforcement in the Mainland China, there is a growing need of effluent treatment technology. Traditionally, ion-exchange resin, polymer ultra-filtration and micro-emulsion are applied in the treatment of plating effluents. However, they all have different weaknesses. Many reports have been published for the separation using aqueous biphasic system. Based on this methodology, polystyrene-grafted-polyglycidol (PS-PG), a water-compatible polymer was synthesized. This type of polymer can be used for gold or silver extraction. After extraction, the recovery of metal can be achieved by direct electro-deposition or reverse extraction using sodium cyanide.postprintThe 2008 AIChE Annual Meeting (AIChE 100), Philadelphia, PA., 16-21 November 2008. In Conference Proceedings, 2008, p. 1-

The fate of hypoechoic cleft

Background: Hypoechoic clefts are small defects found on ultrasonographs in the intact rotator cuff tendon after rotator cuff repair. Little is known about the fate of these hypoechoic clefts, as to whether they will heal, persist, or develop into a retear. Methods: This prospective study involved 24 patients who underwent arthroscopic rotator cuff repair surgery and were found to have a hypoechoic cleft at the 6-month postoperative ultrasonograph. A subsequent ultrasonography follow-up was performed at 9 months or later by the same ultrasonographer and the repair re-examined. Results: At an average postoperative follow-up of 21 months, 14 of the 25 hypoechoic clefts (56%) had healed; 5 (20%) had persistent clefts whereas 6 (24%) had progressed to a full-thickness rotator cuff retear. Patients with a hypoechoic cleft ≥36 mm2 were 5 times more likely to have a retear than patients with hypoechoic cleft <36 mm2 (relative risk = 5.1; P < .05). Patients with hypoechoic clefts ≥36 mm2 had a higher frequency of pain during activity and sleep and a lower level of satisfaction at the 21-month follow-up compared to those with small hypoechoic clefts (P = .05). Conclusion: This is the first study to evaluate the natural history of a hypoechoic cleft found at ultrasonography following rotator cuff repair. The study showed that clefts less than 36 mm2 are likely to heal, while those greater than 36 mm2 are at high risk of progressing to full-thickness retears

An innovation approach on the separation of metal

There has been increasing environmental concerns on the metallic pollution in recent decades. The conventional technologies used for metal extraction are ion-exchange resins, polymer ultrafiltration and microemulsion. The whole extraction mechanism can be divided into 4 steps: 1) The binding of dissolved metal to active sites, 2) Separation of the metal load extractant from the lean phase, 3) Reverse extraction of loaded metal for recovery 4) Recycling of extractant for repeated extraction. Each of the conventional methods suffers different drawbacks in different steps of the extraction mechanism….postprintThe 2008 AIChE Annual Meeting (AIChE 100), Philadelphia, PA., 16-21 November 2008. In Proceedings of the 2008 AIChE Annual Meeting, AIChE 10

Evaluation of the Effectiveness of Nurse-Led Continence Care Treatments for Chinese Primary Care Patients with Lower Urinary Tract Symptoms

published_or_final_versio

Continuous Variable Quantum State Sharing via Quantum Disentanglement

Quantum state sharing is a protocol where perfect reconstruction of quantum states is achieved with incomplete or partial information in a multi-partite quantum networks. Quantum state sharing allows for secure communication in a quantum network where partial information is lost or acquired by malicious parties. This protocol utilizes entanglement for the secret state distribution, and a class of "quantum disentangling" protocols for the state reconstruction. We demonstrate a quantum state sharing protocol in which a tripartite entangled state is used to encode and distribute a secret state to three players. Any two of these players can collaborate to reconstruct the secret state, whilst individual players obtain no information. We investigate a number of quantum disentangling processes and experimentally demonstrate quantum state reconstruction using two of these protocols. We experimentally measure a fidelity, averaged over all reconstruction permutations, of F = 0.73. A result achievable only by using quantum resources.Comment: Published, Phys. Rev. A 71, 033814 (2005) (7 figures, 11 pages

Patterns of health-related quality of life and associated factors in Chinese patients undergoing haemodialysis

Background: Haemodialysis (HD) is a life-saving but burdensome therapy for patients with end-stage renal disease (ESRD) which can have a detrimental impact on patients’ quality of life and outcomes. There is currently little data on the health related quality of life (HRQOL) of Chinese ESRD patients undergoing HD and this study sought to examine the patterns of HRQOL and its associated factors within this population, as well as in comparison with the general local population. Methods: A cross-sectional study of 244 ESRD patients receiving HD in the hospital and in the community in Hong Kong was conducted using the Short Form-12 Health Survey version 2 (SF-12v2). All study subjects were one-to-one matched with subjects in a Hong Kong general population database by sex and exact age. Independent t-tests were performed to compare the mean SF-12v2 scores between HD patients and the general population, followed by one-way analysis of variance with post hoc Tukey’s HSD tests to compare community-based haemodialysis, hospital-based haemodialysis and the general population. Multiple linear regressions were used to identify the factors (socio-demographic, clinical characteristics and comorbidities) associated with the HRQOL scores of ESRD patients receiving HD. Results: The SF-12v2 Physical Functioning, Role Physical, Bodily Pain, General Health and Physical Component Summary scores of HD patients were significantly lower than the age-sex adjusted general population. However, the SF-12v2 Mental Health and Mental Component Summary scores of HD patients were significantly higher than the corresponding general population. Poorer HRQOL was associated with being female, smoking, unemployment and hospital-based haemodialysis. Conclusions: HD patients had substantially poorer physical HRQOL but better mental HRQOL than the age-sex adjusted general population. Patients receiving HD in the community setting had better HRQOL. Reasons for these observations will need to be further investigated. Those patients who are female, smokers and unemployed may warrant more attention as their poorer HRQOL may be associated with poorer outcomes.published_or_final_versio

Prepared by:

OEHHA also acknowledges the following contributors