A re-analysis of the isolated black hole candidate OGLE-2011-BLG-0462/MOA-2011-BLG-191

There are expected to be $\sim 10^8$ isolated black holes (BHs) in the Milky Way. OGLE-2011-BLG-0462/MOA-2011-BLG-191 (OB110462) is the only such BH with a mass measurement to date. However, its mass is disputed: Lam et al. (2022a,b) measured a lower mass of $1.6 - 4.4 M_\odot$, while Sahu et al. (2022); Mr\'{o}z et al. (2022) measured a higher mass of $5.8 - 8.7 M_\odot$. We re-analyze OB110462, including new data from the Hubble Space Telescope (HST) and re-reduced Optical Gravitational Lensing Experiment (OGLE) photometry. We also re-reduce and re-analyze the HST dataset with newly available software. We find significantly different ($\sim 1$ mas) HST astrometry than Lam et al. (2022a,b) in the de-magnified epochs due to the amount of positional bias induced by a bright star $\sim$0.4 arcsec from OB110462. After modeling the updated photometric and astrometric datasets, we find the lens of OB110462 is a $6.0^{+1.2}_{-1.0} M_\odot$ BH. Future observations with the Nancy Grace Roman Space Telescope, which will have an astrometric precision comparable or better to HST but a field of view $100\times$ larger, will be able to measure hundreds of isolated BH masses via microlensing. This will enable the measurement of the BH mass distribution and improve understanding of massive stellar evolution and BH formation channels.Comment: 23 pages, 18 figures, 8 tables. Accepted for publication in ApJ on 2 Aug 2023 [Same as v1, just fixed typo in email address

Natal Kicks from the Galactic Center and Implications on their Environment and the Roman Space Telescope

Most galaxies, including the Milky Way, harbor a central supermassive black hole (SMBH) weighing millions to billions of solar masses. Surrounding these SMBHs are dense regions of stars and stellar remnants, such as neutron stars and black holes. Neutron stars and possibly black holes receive large natal kicks at birth on the order of hundreds of km s$^{-1}$. The natal kicks that occur in the vicinity of an SMBH may redistribute the orbital configuration of the compact objects and alter their underlying density distribution. We model the effects of natal kicks on a Galactic Center (GC) population of massive stars and stellar binaries with different initial density distributions. Using observational constraints from stellar orbits near the GC, we place an upper limit on the steepness of the initial stellar profile and find it to be core-like. In addition, we predict that $30-70 \%$ of compact objects become unbound from the SMBH due to their kicks and will migrate throughout the galaxy. Different black hole kick prescriptions lead to distinct spatial and kinematic distributions. We suggest that the Roman Space Telescope may be able to distinguish between these distributions and thus be able to differentiate natal kick mechanisms.Comment: 18 pages, 11 Figure

Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells.

Endothelial cells (ECs) are critical determinants of vascular homeostasis and inflammation, but transcriptional mechanisms specifying their identities and functional states remain poorly understood. Here, we report a genome-wide assessment of regulatory landscapes of primary human aortic endothelial cells (HAECs) under basal and activated conditions, enabling inference of transcription factor networks that direct homeostatic and pro-inflammatory programs. We demonstrate that 43% of detected enhancers are EC-specific and contain SNPs associated to cardiovascular disease and hypertension. We provide evidence that AP1, ETS, and GATA transcription factors play key roles in HAEC transcription by co-binding enhancers associated with EC-specific genes. We further demonstrate that exposure of HAECs to oxidized phospholipids or pro-inflammatory cytokines results in signal-specific alterations in enhancer landscapes and associate with coordinated binding of CEBPD, IRF1, and NFκB. Collectively, these findings identify cis-regulatory elements and corresponding trans-acting factors that contribute to EC identity and their specific responses to pro-inflammatory stimuli

Microlensing Events in Five Years of Photometry from the Zwicky Transient Facility

Microlensing has a unique advantage for detecting dark objects in the Milky Way, such as free floating planets, neutron stars, and stellar-mass black holes. Most microlensing surveys focus towards the Galactic bulge, where higher stellar density leads to a higher event rate. However, microlensing events in the Galactic plane are closer, and take place over longer timescales. This enables a better measurement of the microlensing parallax, which serves as an independent constraint on the mass of the dark lens. In this work, we systematically searched for microlensing events in Zwicky Transient Facility (ZTF) Data Release 17 from 2018--2023 in the Galactic plane region $|b| < 20^\circ$. We find 124 high-confidence microlensing events and 54 possible events. In the event selection, we use the efficient \texttt{EventFinder} algorithm to detect microlensing signals, which could be used for large datasets such as future ZTF data releases or data from the Rubin Observatory Legacy Survey of Space and Time (LSST). With detection efficiencies of ZTF fields from catalog-level simulations, we calculate the mean Einstein timescale to be $\langle t_\mathrm{E}\rangle = 51.7 \pm 3.3$ days, smaller than previous results of the Galactic plane to within 1.5-$\sigma$. We calculate optical depths and event rates, which we interpret with caution due to the use of visual inspection in creating our final sample. With two years of additional ZTF data in DR17, we have more than doubled the amount of microlensing events (60) found in the three-year DR5 search and found events with longer Einstein timescales than before.Comment: 9 figures, 3 tables. Submitted to Ap

Gravitational Microlensing Event Statistics for the Zwicky Transient Facility

Microlensing surveys have discovered thousands of events with almost all events discovered within the Galactic bulge or toward the Magellanic clouds. The Zwicky Transient Facility (ZTF), while not designed to be a microlensing campaign, is an optical time-domain survey that observes the entire northern sky every few nights including the Galactic plane. ZTF observes $\sim10^9$ stars in g-band and r-band and can significantly contribute to the observed microlensing population. We predict that ZTF will observe $\sim$1100 microlensing events in three years of observing within $10^\circ$ degrees latitude of the Galactic plane, with $\sim$500 events in the outer Galaxy ($\ell \geq 10^\circ$). This yield increases to $\sim$1400 ($\sim$800) events by combining every three ZTF exposures, $\sim$1800 ($\sim$900) events if ZTF observes for a total of five years, and $\sim$2400 ($\sim$1300) events for a five year survey with post-processing image stacking. Using the microlensing modeling software PopSyCLE, we compare the microlensing populations in the Galactic bulge and the outer Galaxy. We also present an analysis of the microlensing event ZTF18abhxjmj to demonstrate how to leverage these population statistics in event modeling. ZTF will constrain Galactic structure, stellar populations, and primordial black holes through photometric microlensing.Comment: 19 pages, 13 figures, 5 tables, accepted to ApJ (6/4/2020), microlensing simulation catalogs available at https://portal.nersc.gov/project/uLens/Galactic_Microlensing_Distribution