22 research outputs found

    Electrochemical, Regioselective, and Stereoselective Synthesis of Allylic Thioethers and Selenoethers under Transition-Metal-Free and Oxidant-Free Conditions

    No full text
    We disclose a mild, scalable, electricity-promoted cross coupling protocol between allylic iodides and disulfides/diselenides for the formation of C–S/Se bonds in the absence of transition metals, bases, and oxidants. The stereochemically different densely functionalized allylic iodides gave regio- and stereoselective diverse thioethers in good yields. This strategy demonstrates a sustainable promising approach for the synthesis of allylic thioethers in 38–80% yields. This protocol also provides a synthetic platform for the synthesis of allylic selenoethers. A single-electron transfer radical pathway was also validated with radical scavenger experiments and cyclic voltammetry data

    Electrochemical, Regioselective, and Stereoselective Synthesis of Allylic Thioethers and Selenoethers under Transition-Metal-Free and Oxidant-Free Conditions

    No full text
    We disclose a mild, scalable, electricity-promoted cross coupling protocol between allylic iodides and disulfides/diselenides for the formation of C–S/Se bonds in the absence of transition metals, bases, and oxidants. The stereochemically different densely functionalized allylic iodides gave regio- and stereoselective diverse thioethers in good yields. This strategy demonstrates a sustainable promising approach for the synthesis of allylic thioethers in 38–80% yields. This protocol also provides a synthetic platform for the synthesis of allylic selenoethers. A single-electron transfer radical pathway was also validated with radical scavenger experiments and cyclic voltammetry data

    Electrochemical Bisarylation of Carbonyls: A Direct Synthetic Strategy for Bis(indolyl)methane

    No full text
    An interesting electrochemical direct bisarylation of carbonyls with indole derivatives to afford the corresponding bis(indolyl)methane (BIM) derivatives is described. The developed protocol is suitable for aliphatic, aromatic, and heteroaromatic aldehydes, which react with various electron-rich and electron-poor indoles to afford the corresponding BIMs in good to excellent yields. Isatin derivatives also underwent bisarylation with various indole derivatives under the influence of current to afford the corresponding BIMs in excellent yields

    Electrochemical Bisarylation of Carbonyls: A Direct Synthetic Strategy for Bis(indolyl)methane

    No full text
    An interesting electrochemical direct bisarylation of carbonyls with indole derivatives to afford the corresponding bis(indolyl)methane (BIM) derivatives is described. The developed protocol is suitable for aliphatic, aromatic, and heteroaromatic aldehydes, which react with various electron-rich and electron-poor indoles to afford the corresponding BIMs in good to excellent yields. Isatin derivatives also underwent bisarylation with various indole derivatives under the influence of current to afford the corresponding BIMs in excellent yields
    corecore