25 research outputs found
Quali-quantitative evaluation of ileal peyer's patches innervation in scrapie-free or scrapie-affected sarda breed ovines
Although Peyer's patches (PPs) and the enteric nervous system (ENS) play a key role in early sheep scrapie
pathogenesis, little is known on the kinetics of ENS plexuses colonization.
This study was aimed at quali-quantitatively evaluating ileal PP innervation in 29 Sarda breed ovines (12 scrapie-free, 2
months-old lambs, 4 ARQ/ARQ, 4 ARR/ARQ and 4 ARR/ARR, respectively; 12 scrapie-free, 2-4 years-old sheep, 3
ARQ/ARQ, 7 ARR/ARQ and 2 ARR/ARR, respectively; 5 ARQ/ARQ scrapie-affected sheep)
Pathogenetic investigations on the enteric nervous system plexuses of sarda breed sheep with different PrP genotypes following oral experimental scrapie infection
We investigated the ileal myenteric (MPs) and submucosal plexuses (SMPs) of 32 Sarda breed sheep carrying
different PrP genotypes (ARQ/ARQ, ARQ/AHQ, ARQ/ARR, ARR/ARR), which had been orally dosed with
scrapie at 8 months of age and euthanized at definite time intervals post-infection (p.i.)