Synthesis of Carboxamide and Sulfonyl Carboxamide Linked Azoles Under Green Conditions

Direct coupling of heteroaldehydes with heteroaryl amines/sulfonylamines is performed under green conditions using PEG-400 in the presence of oxidant CCl3CN/H2O2. The presence of electron-withdrawing substituents on heteroaldehydes increased the yield. Further heteroaryl amines favor the reaction when compared with heteroaryl sulfonylamines. © 2020 Author(s).One of the authors G. Lakshmi Teja is indebted to the University Grants Commission (UGC), New Delhi for sanction of UGC-BSR fellowship

Psychological effects of COVID-19 on patients with cancer, their caregivers: A systematic review

There is limited study reporting the severity of anxiety and depression in cancer cohort and their caregivers. We aimed in this systematic review to determine the prevalence of stress, anxiety, depression among comprehensive cancer patient and their caregivers during COVID-19 pandemic. A systematic review search was performed on PubMed, PsycINFO, CINAHL, and Scopus till June 2021. PRISMA guidelines were used in this systematic review. Reviews were performed to collect all original research articles to describe prevalence of stress, anxiety, depression among the cancer patients and their caregivers. All analysis was done by using RStudio version 1.0.136. 4 studies from our search criteria were eligible for inclusion for anxiety symptoms. Meta-analyses revealed that no any significant difference in incidence of anxiety in cancer and their caregivers. The pooled odds ratio 1.00 [95% CI; 0.87- 1.15]. Pooled prevalence in patients and their caregivers 49% [25%; 74%] and 50% [26%; 73%] respectively.  Anxiety was relatively higher in cancer patients and their care givers. Isolation, married caregivers showed most significant factor to increase anxiety in cancer patients and their care givers. This metaanalyses suggest that prevalence of anxiety in cancer patients and their caregivers were significantly increasing during COVID-19